16 Questions
Which enzyme is responsible for cleaving C4 and C2 in the classical pathway of the complement system?
C1s
What complex is formed by the combination of C4b and C2a in the classical pathway?
C4b2a
Which fragment of C3 is a powerful opsonin?
C3a
Which group of molecules bind and form pores that resemble Natural Killer cells in the complement system?
C6, C7, C8, C9
What activates C2 with the help of Magnesium in the complement system?
C1s
What is the function of Membrane Attack Complex (MAC)?
Promotes cell lysis
What is the role of MASP-2 in the complement system?
Homologous to C1s
Which pathway in the complement system is activated by aggregates of IgA and IgG4?
Alternative Pathway
What activates the Alternative Pathway in the complement system according to the text?
Presence of mannose in pathogens
Which component is found in serum and is important in the MBL pathway?
MASP-1
What is the function of MBL-associated serine proteases in the complement system?
Important proteases in the MBL pathway
What represents the most significant step in the entire process of complement activation?
Cleavage of C3 to C3b
Which protein serves as a cofactor with Factor I that inactivates C4b, inhibiting C3 convertase formation?
C4-Binding Protein (C4BP)
Which protein is a cofactor with Factor I that binds to C4b and C3b in the classical and MBL pathways?
Membrane Cofactor Protein (MCP)
Which protein is known as the most efficient cofactor for Factor I-mediated cleavage of C3b, and also cleaves C4b but less effectively?
Factor H
Which protein is involved in the alternative pathway by inhibiting the binding of Factor B to C3b?
Membrane Inhibitor of Reactive Lysis (MIRL)
Test your knowledge on the cascade of events in the complement system activation, from C1qrs enzyme activation to the formation of C3 convertase. Understand the roles of C1s, C4, C2, and C3 in the classical pathway of complement activation.
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