Complement System Cascade Quiz
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Questions and Answers

Which enzyme is responsible for cleaving C4 and C2 in the classical pathway of the complement system?

  • C2a
  • C1s (correct)
  • C1qrs
  • C3 convertase
  • What complex is formed by the combination of C4b and C2a in the classical pathway?

  • C4b2a (correct)
  • C2aC4b
  • C3 convertase
  • C5 convertase
  • Which fragment of C3 is a powerful opsonin?

  • C3a (correct)
  • C5a
  • C4b
  • C2a
  • Which group of molecules bind and form pores that resemble Natural Killer cells in the complement system?

    <p>C6, C7, C8, C9</p> Signup and view all the answers

    What activates C2 with the help of Magnesium in the complement system?

    <p>C1s</p> Signup and view all the answers

    What is the function of Membrane Attack Complex (MAC)?

    <p>Promotes cell lysis</p> Signup and view all the answers

    What is the role of MASP-2 in the complement system?

    <p>Homologous to C1s</p> Signup and view all the answers

    Which pathway in the complement system is activated by aggregates of IgA and IgG4?

    <p>Alternative Pathway</p> Signup and view all the answers

    What activates the Alternative Pathway in the complement system according to the text?

    <p>Presence of mannose in pathogens</p> Signup and view all the answers

    Which component is found in serum and is important in the MBL pathway?

    <p>MASP-1</p> Signup and view all the answers

    What is the function of MBL-associated serine proteases in the complement system?

    <p>Important proteases in the MBL pathway</p> Signup and view all the answers

    What represents the most significant step in the entire process of complement activation?

    <p>Cleavage of C3 to C3b</p> Signup and view all the answers

    Which protein serves as a cofactor with Factor I that inactivates C4b, inhibiting C3 convertase formation?

    <p>C4-Binding Protein (C4BP)</p> Signup and view all the answers

    Which protein is a cofactor with Factor I that binds to C4b and C3b in the classical and MBL pathways?

    <p>Membrane Cofactor Protein (MCP)</p> Signup and view all the answers

    Which protein is known as the most efficient cofactor for Factor I-mediated cleavage of C3b, and also cleaves C4b but less effectively?

    <p>Factor H</p> Signup and view all the answers

    Which protein is involved in the alternative pathway by inhibiting the binding of Factor B to C3b?

    <p>Membrane Inhibitor of Reactive Lysis (MIRL)</p> Signup and view all the answers

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