Complement System Cascade Quiz

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Questions and Answers

Which enzyme is responsible for cleaving C4 and C2 in the classical pathway of the complement system?

  • C2a
  • C1s (correct)
  • C1qrs
  • C3 convertase

What complex is formed by the combination of C4b and C2a in the classical pathway?

  • C4b2a (correct)
  • C2aC4b
  • C3 convertase
  • C5 convertase

Which fragment of C3 is a powerful opsonin?

  • C3a (correct)
  • C5a
  • C4b
  • C2a

Which group of molecules bind and form pores that resemble Natural Killer cells in the complement system?

<p>C6, C7, C8, C9 (C)</p> Signup and view all the answers

What activates C2 with the help of Magnesium in the complement system?

<p>C1s (B)</p> Signup and view all the answers

What is the function of Membrane Attack Complex (MAC)?

<p>Promotes cell lysis (D)</p> Signup and view all the answers

What is the role of MASP-2 in the complement system?

<p>Homologous to C1s (C)</p> Signup and view all the answers

Which pathway in the complement system is activated by aggregates of IgA and IgG4?

<p>Alternative Pathway (A)</p> Signup and view all the answers

What activates the Alternative Pathway in the complement system according to the text?

<p>Presence of mannose in pathogens (B)</p> Signup and view all the answers

Which component is found in serum and is important in the MBL pathway?

<p>MASP-1 (C)</p> Signup and view all the answers

What is the function of MBL-associated serine proteases in the complement system?

<p>Important proteases in the MBL pathway (C)</p> Signup and view all the answers

What represents the most significant step in the entire process of complement activation?

<p>Cleavage of C3 to C3b (D)</p> Signup and view all the answers

Which protein serves as a cofactor with Factor I that inactivates C4b, inhibiting C3 convertase formation?

<p>C4-Binding Protein (C4BP) (D)</p> Signup and view all the answers

Which protein is a cofactor with Factor I that binds to C4b and C3b in the classical and MBL pathways?

<p>Membrane Cofactor Protein (MCP) (B)</p> Signup and view all the answers

Which protein is known as the most efficient cofactor for Factor I-mediated cleavage of C3b, and also cleaves C4b but less effectively?

<p>Factor H (B)</p> Signup and view all the answers

Which protein is involved in the alternative pathway by inhibiting the binding of Factor B to C3b?

<p>Membrane Inhibitor of Reactive Lysis (MIRL) (A)</p> Signup and view all the answers

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