10 Questions
What are the major components of sequence alignment?
Type of the alignment, scoring system, algorithm, statistical method
What is the difference between local and global sequence alignment?
Local alignment prioritizes highest similarity matches and aligns substring; global alignment aligns whole string with end-to-end approach.
What do you need to consider when comparing sequences?
Deletions/insertions, substitutions, recombination
What are the types of sequence alignment?
Pairwise vs Multiple sequence alignment; Local vs Global alignment
Which website provides information about the difference between global and local sequence alignments?
Which method of Multiple Sequence Alignment (MSA) is guided by a phylogenetic tree?
Progressive alignment method (ClustalW)
What is the probability calculation for multiple sequence alignment based on the correct phylogenetic tree?
The product of the probabilities of all the evolutionary events necessary to produce that alignment
Which method of Multiple Sequence Alignment (MSA) is homology-based?
Homology-based method (MAFFT)
Which type of sequence alignment does MAFFT utilize as a basis for its method?
Sequence-based alignment
What is the main focus of iterative refinement methods such as PRALINE, MUSCLE, and T-COFFEE in Multiple Sequence Alignment (MSA)?
Sequence divergence
Test your knowledge of comparing sequences, sequence databases, sequence comparison, pairwise alignment, multiple sequence alignment, and phylogenetic trees in the context of computational molecular microbiology.
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