Lec 11: Community-Acquired Pneumonia (CAP)

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Questions and Answers

Which of the following is a physiological defense mechanism in the nasopharynx?

  • Alveolar macrophages
  • Airway surface liquid
  • Nasal hair (correct)
  • Cough reflex

What is the role of the mucociliary apparatus in respiratory defense?

  • Generating cough
  • Producing saliva
  • Secreting IgA
  • Trapping and removing pathogens (correct)

Where is IgA secretion a defense mechanism?

  • Alveoli
  • Lower respiratory tract
  • Nasopharynx (correct)
  • Conducting airways

Which of these is a defense mechanism in the oropharynx?

<p>Saliva (C)</p> Signup and view all the answers

Cough is a defense mechanism primarily located in the:

<p>Conducting airways (B)</p> Signup and view all the answers

Which of the following is part of the host defense mechanisms in the lower respiratory tract?

<p>Alveolar macrophages (B)</p> Signup and view all the answers

What is the function of alveolar lining fluid?

<p>To facilitate gas exchange and provide defense (C)</p> Signup and view all the answers

Which of the following can impair pulmonary defenses?

<p>Cigarette smoke (A)</p> Signup and view all the answers

Alcohol consumption impairs which pulmonary defense mechanisms?

<p>Epiglottic and cough reflexes (A)</p> Signup and view all the answers

Mycoplasma pneumoniae and Haemophilus influenzae interfere with:

<p>Normal ciliary function (B)</p> Signup and view all the answers

Respiratory viruses can inhibit which immune cell function?

<p>Neutrophil function (B)</p> Signup and view all the answers

What is the definition of community-acquired pneumonia (CAP)?

<p>Acute lung infection acquired outside of a hospital/healthcare setting (C)</p> Signup and view all the answers

Diagnosis of CAP requires acute infection of pulmonary parenchyma and support from at least one of the following EXCEPT:

<p>Blood culture (C)</p> Signup and view all the answers

In the United States, the incidence of CAP is approximately how many episodes per 10,000 adults?

<p>25 (B)</p> Signup and view all the answers

The incidence of CAP is higher in which age group?

<p>Older adults (D)</p> Signup and view all the answers

Which of the following is a risk factor for community-acquired pneumonia (CAP)?

<p>Older age (B)</p> Signup and view all the answers

COPD is a risk factor for CAP and falls under which category of risk factors?

<p>Chronic comorbidities (A)</p> Signup and view all the answers

Influenza virus is the most common cause of which type of infection related to CAP risk?

<p>Viral respiratory infections (B)</p> Signup and view all the answers

Smoking and alcohol abuse are risk factors for CAP because they lead to:

<p>Impaired airway protection (D)</p> Signup and view all the answers

Crowded living conditions are a risk factor for CAP and fall under which category?

<p>Living conditions (C)</p> Signup and view all the answers

Which of the following is the most common bacterial cause of CAP?

<p>Streptococcus pneumoniae (C)</p> Signup and view all the answers

Mycoplasma pneumoniae is classified as which type of bacteria in CAP etiology?

<p>Atypical bacteria (D)</p> Signup and view all the answers

Influenza viruses are categorized under which etiological agent for CAP?

<p>Respiratory viruses (A)</p> Signup and view all the answers

Which of the following is considered an atypical bacterial cause of CAP?

<p>Legionella spp (A)</p> Signup and view all the answers

Rhinoviruses are classified as:

<p>Respiratory viruses (A)</p> Signup and view all the answers

In outpatient CAP, which of the following is a common etiological agent?

<p>S. pneumoniae (C)</p> Signup and view all the answers

Which of the following is a systemic finding in clinical presentation of CAP?

<p>Fatigue (D)</p> Signup and view all the answers

Rales and ronchi are examples of which type of findings in CAP?

<p>Auscultatory findings (D)</p> Signup and view all the answers

Lobar consolidation is a type of:

<p>Radiographic finding (D)</p> Signup and view all the answers

Diagnosis of CAP typically requires radiographic evidence and:

<p>Signs and symptoms (C)</p> Signup and view all the answers

CURB-65 is a tool used for assessing:

<p>Severity of CAP (A)</p> Signup and view all the answers

In CURB-65, 'C' stands for:

<p>Confusion (C)</p> Signup and view all the answers

A CURB-65 score of 0-1 indicates:

<p>Low risk pneumonia, consider home treatment (A)</p> Signup and view all the answers

IDSA/ATS severity criteria for severe CAP include major and:

<p>Minor criteria (C)</p> Signup and view all the answers

Respiratory rate ≥ 30 breaths/min is considered which type of criterion in IDSA/ATS severity assessment?

<p>Minor criterion (D)</p> Signup and view all the answers

Septic shock requiring vasopressors is considered a:

<p>Major criterion (A)</p> Signup and view all the answers

For outpatient CAP diagnosis, blood or sputum culture is generally:

<p>Not recommended (optional) (A)</p> Signup and view all the answers

For inpatient CAP diagnosis, blood or sputum culture is recommended if:

<p>It is severe CAP (B)</p> Signup and view all the answers

Severity of CAP is a factor to consider when selecting a drug regimen and is determined by:

<p>PSI or CURB-65, IDSA/ATS criteria (B)</p> Signup and view all the answers

For outpatient CAP treatment in patients without comorbidities, which antibiotic class is recommended?

<p>Macrolides (D)</p> Signup and view all the answers

For outpatient CAP treatment with comorbidities, which antibiotic class is recommended as monotherapy?

<p>Respiratory fluoroquinolones (D)</p> Signup and view all the answers

For inpatient, non-severe CAP, a recommended antibiotic therapy is:

<p>Combination therapy with beta-lactam + macrolide (D)</p> Signup and view all the answers

Which of the following is a host defense mechanism present in the lower respiratory tract?

<p>Alveolar macrophages (B)</p> Signup and view all the answers

Which of the following can directly disrupt mucociliary function in the lungs?

<p>Cigarette smoke (C)</p> Signup and view all the answers

What is the primary definition of community-acquired pneumonia (CAP)?

<p>Acute lung infection obtained outside of a healthcare setting (C)</p> Signup and view all the answers

Which age group generally has a higher incidence of community-acquired pneumonia (CAP)?

<p>Older adults (65+ years) (D)</p> Signup and view all the answers

Which of the following is a significant risk factor for developing community-acquired pneumonia (CAP)?

<p>Chronic Obstructive Pulmonary Disease (COPD) (A)</p> Signup and view all the answers

Which of the following is identified as the most common bacterial cause of CAP?

<p>Streptococcus pneumoniae (B)</p> Signup and view all the answers

Which of these viruses is most frequently associated with viral respiratory infections that increase the risk of CAP?

<p>Influenza virus (A)</p> Signup and view all the answers

Which of the following physical exam findings are associated with CAP?

<p>Chest discomfort (D)</p> Signup and view all the answers

What is one of the key systemic findings observed in the clinical presentation of CAP?

<p>Fatigue (A)</p> Signup and view all the answers

Which diagnostic element is typically required in addition to clinical signs and symptoms for confirming CAP?

<p>Radiographic evidence (A)</p> Signup and view all the answers

When should blood or sputum cultures be performed when diagnosing CAP as an inpatient?

<p>If severe CAP is suspected. (C)</p> Signup and view all the answers

Which is a key factor to consider when choosing an antibiotic regimen for CAP?

<p>The severity of their CAP (B)</p> Signup and view all the answers

If an outpatient has no comorbidities, that which antibiotic class is frequently recommended for CAP?

<p>Amoxicillin (D)</p> Signup and view all the answers

What is a recommended treatment for inpatient, non-severe CAP?

<p>Ceftriaxone and azithromycin (A)</p> Signup and view all the answers

According to current guidelines, when should treatment of influenza be initiated for best results?

<p>As soon as possible and ideally within 48 hours after the onset of illness (A)</p> Signup and view all the answers

According to current guidelines, whom should treament be offered for influenza?

<p>Treatment should only be offered to people at high risk for complications from flu (D)</p> Signup and view all the answers

What is the recommendation for annual flu vaccines?

<p>Universal annual vaccination (D)</p> Signup and view all the answers

What type of influenza is in influenza vaccines?

<p>A and B (C)</p> Signup and view all the answers

What is not a contradiction for live attenuated vaccine?

<p>Only those with a comorbidity predisposing illness. (C)</p> Signup and view all the answers

When do you see a rare bacterial bacterial co-pneumonia occurring in MERS-CoV?

<p>With tuberculosis. (B)</p> Signup and view all the answers

Which of the following is a physiological defense mechanism primarily located in the conducting airways (trachea, bronchi)?

<p>Mucociliary apparatus (D)</p> Signup and view all the answers

Disruption of the mucociliary escalator in the respiratory tract can be directly caused by which of the following?

<p>Cigarette smoke inhalation (D)</p> Signup and view all the answers

A patient with altered consciousness is at increased risk of pneumonia because of:

<p>Compromised epiglottic closure (C)</p> Signup and view all the answers

Alcohol consumption increases the risk of pneumonia by impairing which of the following pulmonary defense mechanisms?

<p>Impaired epiglottic and cough reflexes (D)</p> Signup and view all the answers

Which of the following factors related to Human Immunodeficiency Virus (HIV) infection impairs pulmonary defenses and increases pneumonia risk?

<p>Decreased quantitative and qualitative CD4 T-cell response (D)</p> Signup and view all the answers

What is the estimated annual incidence of community-acquired pneumonia (CAP) in the United States among adults?

<p>25 episodes per 10,000 adults (D)</p> Signup and view all the answers

Which age group exhibits the highest incidence rate of community-acquired pneumonia (CAP)?

<p>Adults aged 80 years and older (B)</p> Signup and view all the answers

Chronic Obstructive Pulmonary Disease (COPD) is a significant risk factor for community-acquired pneumonia (CAP) because it primarily represents:

<p>Chronic comorbidity (C)</p> Signup and view all the answers

Influenza virus infection increases the risk of community-acquired pneumonia (CAP) primarily by:

<p>Causing viral respiratory infection (A)</p> Signup and view all the answers

Smoking and alcohol abuse are categorized as risk factors for community-acquired pneumonia (CAP) because they lead to:

<p>Impaired airway protection (C)</p> Signup and view all the answers

What is the most frequently identified bacterial pathogen in community-acquired pneumonia (CAP)?

<p>Streptococcus pneumoniae (C)</p> Signup and view all the answers

Mycoplasma pneumoniae is classified as which type of etiological agent in the context of community-acquired pneumonia (CAP)?

<p>Atypical bacteria (D)</p> Signup and view all the answers

Among respiratory viruses, which is the most common viral etiology associated with community-acquired pneumonia (CAP)?

<p>Influenza viruses (D)</p> Signup and view all the answers

In an outpatient setting, which of the following is considered a common etiological agent for community-acquired pneumonia (CAP)?

<p>Streptococcus pneumoniae (A)</p> Signup and view all the answers

Systemic findings in the clinical presentation of community-acquired pneumonia (CAP) commonly include:

<p>Fever and sweats (A)</p> Signup and view all the answers

Rales and ronchi, identified during auscultation, are classified as which type of findings in community-acquired pneumonia (CAP)?

<p>Auscultatory findings (D)</p> Signup and view all the answers

Lobar consolidation, as seen on chest X-ray, is categorized as which type of finding in community-acquired pneumonia (CAP)?

<p>Radiographic finding (B)</p> Signup and view all the answers

Diagnosis of community-acquired pneumonia (CAP) requires clinical signs and symptoms in addition to:

<p>Radiographic evidence (C)</p> Signup and view all the answers

CURB-65 is a clinical prediction rule primarily used for assessing:

<p>Severity of pneumonia (A)</p> Signup and view all the answers

In the CURB-65 scoring system, 'C' stands for:

<p>Confusion (D)</p> Signup and view all the answers

According to CURB-65, a score of 0-1 indicates:

<p>Low-risk pneumonia suitable for outpatient treatment (D)</p> Signup and view all the answers

According to IDSA/ATS severity criteria for severe CAP, respiratory rate ≥ 30 breaths/min is considered:

<p>A minor criterion (A)</p> Signup and view all the answers

Septic shock requiring vasopressors to maintain blood pressure is categorized as:

<p>A major criterion for severe CAP (B)</p> Signup and view all the answers

For outpatient diagnosis of community-acquired pneumonia (CAP), blood or sputum culture is generally:

<p>Not routinely recommended (A)</p> Signup and view all the answers

For inpatients with community-acquired pneumonia (CAP), blood or sputum culture is recommended if:

<p>The patient has severe CAP or risk factors for resistant organisms (B)</p> Signup and view all the answers

Severity of community-acquired pneumonia (CAP) is a crucial factor when selecting a drug regimen and is primarily determined by:

<p>Clinical severity assessment tools like CURB-65 and IDSA/ATS criteria (D)</p> Signup and view all the answers

For outpatient treatment of community-acquired pneumonia (CAP) in patients without comorbidities, which antibiotic class is typically recommended?

<p>Macrolides or doxycycline (C)</p> Signup and view all the answers

For outpatient treatment of community-acquired pneumonia (CAP) in patients with comorbidities, which antibiotic class is recommended as monotherapy?

<p>Respiratory fluoroquinolones (D)</p> Signup and view all the answers

For inpatient, non-severe community-acquired pneumonia (CAP), a recommended antibiotic therapy is:

<p>Beta-lactam plus macrolide (D)</p> Signup and view all the answers

A 33-year-old male with a history of smoking and weekend alcohol use is diagnosed with outpatient CAP. He has no comorbidities. Which of the following is the MOST appropriate antibiotic choice?

<p>Clarithromycin (A)</p> Signup and view all the answers

In the context of influenza treatment for CAP prevention, when should antiviral treatment be initiated for best clinical outcomes?

<p>Within 48 hours of symptom onset (A)</p> Signup and view all the answers

According to current guidelines, influenza antiviral treatment should be offered to which of the following groups?

<p>To people at high risk for complications from influenza (D)</p> Signup and view all the answers

What is the current recommendation regarding annual influenza vaccination for the general population?

<p>Recommended annually for everyone 6 months and older (B)</p> Signup and view all the answers

Current influenza vaccines are designed to protect against which types of influenza viruses?

<p>Influenza A and B viruses (C)</p> Signup and view all the answers

Which of the following is NOT a contraindication for receiving the live attenuated influenza vaccine (LAIV)?

<p>Age greater than 50 years (D)</p> Signup and view all the answers

In the context of MERS-CoV infection, when is bacterial co-pneumonia most likely to occur?

<p>Rarely, as an uncommon complication (A)</p> Signup and view all the answers

Which of the following factors is MOST important to consider when transitioning a patient with CAP from intravenous (IV) to oral (PO) antibiotics?

<p>Clinical stability and ability to tolerate oral medication (A)</p> Signup and view all the answers

For patients with uncomplicated community-acquired pneumonia (CAP) who respond well to treatment, what is generally the minimum recommended duration of antibiotic therapy?

<p>5 days (C)</p> Signup and view all the answers

In cases of suspected or confirmed MRSA or Pseudomonas aeruginosa as causative agents in CAP, the recommended duration of antibiotic treatment typically is:

<p>7 days (B)</p> Signup and view all the answers

Which of the following is a newer aminomethylcycline antibiotic used in the treatment of community-acquired pneumonia (CAP)?

<p>Omadacycline (B)</p> Signup and view all the answers

Delafloxacin, a newer therapy for CAP, belongs to which antibiotic class?

<p>Fluoroquinolones (B)</p> Signup and view all the answers

Lefamulin, a newer agent for CAP treatment, represents which antibiotic class?

<p>Pleuromutilins (B)</p> Signup and view all the answers

Ceftaroline, a newer antibiotic option for CAP, is classified as a:

<p>Cephalosporin (5th generation) (C)</p> Signup and view all the answers

Which of the following represents a physiological defense mechanism specific to the lower respiratory tract (terminal airways, alveoli)?

<p>Alveolar macrophages (C)</p> Signup and view all the answers

A patient with a history of alcohol abuse is admitted with suspected CAP. Which mechanism explains how alcohol consumption increases the risk of pneumonia?

<p>Impaired mucociliary clearance in the airways (C)</p> Signup and view all the answers

Why does an alteration in the level of consciousness increase the risk of CAP?

<p>It can compromise epiglottic closure, leading to aspiration (C)</p> Signup and view all the answers

In a patient with HIV, which factor contributes most significantly to impaired pulmonary defenses and increased CAP risk?

<p>Decreased quantitative and qualitative CD4 T-cell response (C)</p> Signup and view all the answers

Which pre-existing condition poses the greatest risk for the development of community-acquired pneumonia (CAP)?

<p>Chronic Obstructive Pulmonary Disease (COPD) (B)</p> Signup and view all the answers

How does a viral respiratory infection, such as influenza, primarily increase the risk of community-acquired pneumonia (CAP)?

<p>By damaging respiratory epithelium and impairing host defenses (A)</p> Signup and view all the answers

Which intervention is MOST likely to prevent CAP in the general population?

<p>Administering annual influenza vaccinations (C)</p> Signup and view all the answers

If a clinician suspects that that a patient has CAP, what findings are needed to confirm the dx?

<p>Radiographic Evidence plus clinical signs/symptoms (C)</p> Signup and view all the answers

A patient presents with cough, fever, and radiographic evidence of lobar consolidation. Which pathogen classification is MOST likely associated with these findings in CAP?

<p>Typical Bacteria (A)</p> Signup and view all the answers

What key information does the CURB-65 score provide for treating CAP?

<p>Determining the severity of illness and appropriate treatment location (B)</p> Signup and view all the answers

A patient is diagnosed with CAP and has a CURB-65 score of 2. What is the next step?

<p>Consider admission or close outpatient management (B)</p> Signup and view all the answers

Which of the following criteria is considered a major criterion for severe CAP according to the IDSA/ATS guidelines?

<p>Septic shock requiring vasopressors (A)</p> Signup and view all the answers

When treating CAP, what is the role of obtaining blood and sputum cultures?

<p>They are recommended for inpatients, especially those with severe CAP or risk factors for resistant organisms (A)</p> Signup and view all the answers

How does the presence of comorbidities, such as heart disease or diabetes, influence the selection of antibiotic therapy for outpatient CAP?

<p>Combination therapy may be necessary to cover a broader range of pathogens (C)</p> Signup and view all the answers

A previously healthy 25-year-old patient is diagnosed with outpatient CAP. What antibiotic is the the MOST appropriate first-line therapy?

<p>Amoxicillin (D)</p> Signup and view all the answers

A patient with CAP has been receiving intravenous antibiotics in the hospital and is now clinically improving. What is the MOST important requirement to switch the therapy to oral antibiotics?

<p>The patient must be hemodynamically stable, able to ingest medications, and show clinical improvement (A)</p> Signup and view all the answers

A patient is diagnosed with influenza A. According to guidelines, when should antiviral treatment be initiated for the BEST clinical outcome?

<p>As soon as possible, ideally within 48 hours of symptom onset (C)</p> Signup and view all the answers

A 70-year-old patient should be treated for influenza if: (Select the single BEST option)

<p>Treatment should offered to people at high risk for complications from flu (B)</p> Signup and view all the answers

How do current influenza vaccines work to protect against the flu?

<p>By stimulating an immune response to the hemagglutinin (HA) derived from projected viruses (A)</p> Signup and view all the answers

In what scenario is bacterial co-pneumonia MOST commonly observed in cases of MERS-CoV infection?

<p>Bacterial co-pneumonia is rare with MERS-CoV but if present is often atypical bacteria (B)</p> Signup and view all the answers

In the context of host defense mechanisms against CAP, which of the following processes occurs in the lower respiratory tract?

<p>Alveolar macrophage activity (A)</p> Signup and view all the answers

Which of the following best describes how cigarette smoking impairs pulmonary defenses, increasing the risk of CAP?

<p>By disrupting mucociliary function and macrophage activity (C)</p> Signup and view all the answers

A patient with esophageal reflux is at an increased risk of community-acquired pneumonia (CAP), because of:

<p>Predisposition to aspiration (C)</p> Signup and view all the answers

Which of the following is the most accurate statement concerning individuals with HIV and their risk of developing CAP?

<p>HIV-infected individuals are at higher risk for CAP due to deficient antigen-presenting cells. (C)</p> Signup and view all the answers

Which of the following is a key factor that differentiates community-acquired pneumonia (CAP) from other types of pneumonia?

<p>CAP is contracted outside of a healthcare setting. (D)</p> Signup and view all the answers

How does recent influenza infection elevate the risk of developing community-acquired bacterial pneumonia (CAP)?

<p>It damages the respiratory epithelium and impairs neutrophil function. (B)</p> Signup and view all the answers

Which of the following strategies offers the greatest potential for reducing the incidence of CAP in the general population?

<p>Promotion of annual influenza vaccination for all age groups (B)</p> Signup and view all the answers

To confirm a diagnosis of community-acquired pneumonia (CAP) clinically, which specific findings are essential?

<p>New infiltrates on chest radiograph along with consistent clinical signs and symptoms (A)</p> Signup and view all the answers

A patient presents with CAP, exhibiting lobar infiltrates and consolidation on chest X-ray. Which pathogen type is most likely the causative agent?

<p>Typical bacteria, such as Streptococcus pneumoniae (A)</p> Signup and view all the answers

For patients with community-acquired pneumonia (CAP), what is the primary utility of the CURB-65 score?

<p>To assess the severity of the CAP and guide decisions regarding hospitalization (B)</p> Signup and view all the answers

A patient with CAP receives a CURB-65 score of 2. Based on this score, which is the most appropriate clinical decision?

<p>Consider hospital admission versus close outpatient management (B)</p> Signup and view all the answers

Which of the following is considered a major criterion for severe CAP according to the IDSA/ATS guidelines?

<p>Septic shock requiring vasopressors (D)</p> Signup and view all the answers

In the management of CAP, when should blood and sputum cultures be specifically obtained?

<p>Only for inpatients with severe CAP or risk factors for specific pathogens such as MRSA or Pseudomonas (A)</p> Signup and view all the answers

How do comorbidities most significantly influence the selection of antibiotic therapy for outpatient CAP?

<p>Comorbidities typically require broader-spectrum antibiotic coverage (B)</p> Signup and view all the answers

A previously healthy 25-year-old patient is diagnosed with outpatient CAP. The most appropriate first-line antibiotic therapy would be:

<p>Azithromycin (C)</p> Signup and view all the answers

A patient with CAP has been receiving intravenous (IV) antibiotics and is now clinically improving. What is a critical requirement for switching to oral antibiotics?

<p>The patient must be hemodynamically stable, improving clinically, able to take oral medications, and have a functioning GI tract (A)</p> Signup and view all the answers

A patient tests positive for influenza A. According to current guidelines, when should antiviral treatment be initiated for the BEST clinical outcome?

<p>Within 48 hours of symtpom onset (D)</p> Signup and view all the answers

If a 70 year-old patient tests positive for inflenza, which of the following criteria represents the BEST recommendation to prescribe antiviral tratement?

<p>The patient should be treated regardless of risk factors (C)</p> Signup and view all the answers

How do current influenza vaccines elicit protection against influenza infections?

<p>By stimulating the production of antibodies against hemagglutinin (HA) derived from projected viruses for that season (D)</p> Signup and view all the answers

In the context of MERS-CoV infection, when is bacterial co-infection most commonly observed?

<p>In the later stages of MERS-CoV infection, particularly in severely ill patients (D)</p> Signup and view all the answers

Which factor is most important when transitioning a patient with CAP from intravenous (IV) to oral (PO) antibiotics?

<p>The patient is clinically and hemodynamically stable, improving, able to take oral meds and has a functioning GI tract (D)</p> Signup and view all the answers

For CAP patients showing good response to treatment, antibiotic duration is usually how long?

<p>5 days (B)</p> Signup and view all the answers

The recommended antibiotic treatment duration for MRSA or Pseudomonas aeruginosa related CAP is:

<p>7 days (C)</p> Signup and view all the answers

A patient with a history of alcohol abuse is admitted with suspected CAP. Why does alcohol consumption increase the risk of pneumonia?

<p>Disrupts mucociliary clearance and macrophage activity (A)</p> Signup and view all the answers

Which intervention is MOST likely to prevent CAP?

<p>Annual Influenza vaccinations (D)</p> Signup and view all the answers

Which of the following mechanisms in the lower respiratory tract relies on secreted proteins to opsonize pathogens, facilitating phagocytosis by alveolar macrophages?

<p>Alveolar lining fluid containing immunoglobulins (C)</p> Signup and view all the answers

A patient recovering from a stroke exhibits decreased epiglottic closure and impaired cough reflex. Which of the following consequences is MOST directly associated with these impairments concerning CAP?

<p>Aspiration of oropharyngeal flora (B)</p> Signup and view all the answers

An 80-year-old patient presents with new-onset confusion, cough, and dyspnea. The patient's daughter reports that the patient has had a decreased appetite and has been weaker than usual for the past 3 days. Based solely on this information, which of the following CURB-65 scores would be MOST applicable?

<p>2 (B)</p> Signup and view all the answers

A patient with CAP is diagnosed with Legionella pneumophila. Reviewing their medication list, which of the following drugs would warrant concern and influence antibiotic selection?

<p>Azithromycin (B)</p> Signup and view all the answers

In managing a patient with severe CAP caused by methicillin-resistant Staphylococcus aureus (MRSA), according to the IDSA/ATS guidelines, which statement BEST encapsulates the recommended approach?

<p>Initiate vancomycin or linezolid and promptly de-escalate based on PCR or culture results. (B)</p> Signup and view all the answers

An immunocompromised patient is diagnosed with CAP and is not responding to initial antibiotic therapy. Sputum cultures reveal a co-infection with Streptococcus pneumoniae and influenza A virus. Which statement BEST reflects the therapeutic strategy?

<p>Continue antibiotics for the bacterial infection and add oseltamivir to target the influenza A virus. (A)</p> Signup and view all the answers

A 68-year-old male with a history of COPD, presents with cough, fever, and dyspnea. His initial CURB-65 score is 2, and he is started on intravenous antibiotics in the hospital. After 48 hours, he is clinically stable, afebrile, and tolerating oral intake. Which factor is MOST critical in the transition of his care from intravenous (IV) to oral (PO) antibiotics?

<p>Verifying that the patient has a normally functioning gastrointestinal tract and can adhere to the medication regimen (D)</p> Signup and view all the answers

A 50-year-old male patient without comorbidities is diagnosed with outpatient CAP. The local pneumococcal resistance rate to macrolides is 20%. Which statement BEST aligns with the IDSA/ATS guidelines for initial antibiotic selection?

<p>Administer high-dose amoxicillin due to its excellent pneumococcal coverage and low resistance rate. (D)</p> Signup and view all the answers

A 72-year-old female, with comorbidities of hypertension and well-controlled type 2 diabetes, is diagnosed with CAP as an outpatient. She has a known allergy to penicillin. Which regimen is MOST appropriate?

<p>Levofloxacin monotherapy (C)</p> Signup and view all the answers

In response to an outbreak of a novel influenza strain in a long-term care facility, which strategy represents the MOST effective approach to minimize the spread of the virus and prevent CAP among residents?

<p>Offer rapid influenza testing for symptomatic residents and initiate antiviral treatment within 48 hours of symptom onset. (A)</p> Signup and view all the answers

Following a surge in MERS-CoV cases, a hospital faces limited resources and diagnostic capabilities. Bacterial co-pneumonia is suspected in several patients. Which factor would be MOST helpful in guiding empiric antibiotic therapy decisions?

<p>Local antibiograms showing the prevalence of antibiotic-resistant bacteria (B)</p> Signup and view all the answers

Which statement accurately describes how cigarette smoking impairs pulmonary defenses, increasing the risk of community-acquired pneumonia (CAP)?

<p>Cigarette smoke disrupts mucociliary function and impairs macrophage activity, leading to reduced clearance of pathogens. (A)</p> Signup and view all the answers

An older adult patient with a history of frequent aspiration events due to esophageal reflux is admitted to the hospital with suspected CAP. If a bacterial etiology is suspected, which ONE of the following organisms is MOST concerning?

<p><em>Klebsiella pneumoniae</em> (D)</p> Signup and view all the answers

A 30-year-old patient with well-managed HIV presents to the clinic with fever, cough, and shortness of breath. Compared to an HIV-negative individual, which statement about his risk of community-acquired pneumonia (CAP) is MOST accurate?

<p>The patient with HIV has a higher risk of CAP compared to an HIV-negative individual, even with well-managed HIV, due to persistent immune dysregulation. (D)</p> Signup and view all the answers

In comparing CAP between the elderly and younger populations, which factor is MOST responsible for the elderly having a distinct presentation?

<p>The elderly tend to exhibit more non-respiratory symptoms (B)</p> Signup and view all the answers

Why does influenza A often lead to community-acquired bacterial pneumonia (CAP)?

<p>It weakens physical defenses, lowering resistance (D)</p> Signup and view all the answers

Which tactic is MOST effective in reducing CAP cases?

<p>Ensuring regular influenza vaccination (B)</p> Signup and view all the answers

To confirm a CAP dx, which two criteria are ESSENTIAL?

<p>Clinical signs/symptoms plus new/recent X-ray findings (A)</p> Signup and view all the answers

When bacterial co-infection is seen MERS-CoV infection, which organisms are MOST concerning?

<p>Atypicals (C)</p> Signup and view all the answers

A patient has been stable and afebrile for 60 hours after they presented with CAP infection in the hospital. After reviewing, their creatinine level is at 3.3 mg/dL. The most significant factor to consider when transitioning from IV to PO after this patient's improvement is:

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Flashcards

Physiologic Defense Mechanisms in CAP

The body's defense processes in CAP, involving physical barriers and immune responses.

Common Organisms in CAP

Common bacteria, viruses, and fungi known to cause community-acquired pneumonia.

CAP Risk Factors

Factors increasing the chance of developing CAP, like age, smoking, or comorbidities.

CAP Treatment Selection Factors

Considering disease severity, patient factors, and local resistance when choosing CAP treatment.

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Recommended CAP Treatments

Standard antibiotic and antiviral medications recommended for treating CAP.

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Appropriate CAP Treatment Selection

Selecting the best CAP treatment based on patient-specific details and clinical context.

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Upper Airway Defense

Host's nasal passages trap particles via hair, turbinates, and mucus before lower airway entry.

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Conducting Airway Defense Mechanisms

Defense mechanisms that clear debris and pathogens from the trachea and bronchi.

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Lower Respiratory Tract Defense

The alveoli are protected by fluids, immune cells, and lymphoid tissue for gas exchange.

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Pneumonia Occurrence Factors

Situations where host defenses break down, leading to pneumonia infection.

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Impaired Pulmonary Defenses

Compromised defenses due to altered consciousness, smoking, or alcohol use.

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Pulmonary Defense Impairment Factors

Diseases and conditions that weaken lung defenses, increasing pneumonia risk.

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Community-Acquired Pneumonia (CAP)

Pneumonia acquired outside of hospitals or healthcare settings, marked acute infection.

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CAP Epidemiology in the U.S.

Frequency and impact of CAP in the U.S., including cases, deaths, and costs.

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Risk factors for CAP

Factors that elevate the risk of contracting community-acquired pneumonia.

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CAP Etiology

Diverse bacteria, viruses, and sometimes fungi causing community-acquired pneumonia.

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Diagnosing CAP

Physical and lab findings guide pneumonia diagnosis.

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Respiratory findings in pneumonia

Cough, sputum, difficulty breathing, and chest pain.

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Systemic findings in pneumonia

Fever, fatigue, sweating, and headaches.

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Radiographic findings in pneumonia

Lobar consolidation and interstitial infiltrates.

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Diagnosis of CAP

Diagnosis from clinical & X-ray.

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Stratify CAP Severity

The PSI and CURB-65 to assess risk.

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Considerations selecting CAP drug

Factors like Inpatient vs outpatient affect choices.

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Severity affects CAP regimen

Based on PSI or CURB-65, IDSA/ATS criteria

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When changing CAP Drugs

Switch to oral when stable, afebrile, and GI functions.

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Viral CAP

The etiology, signs and symptoms of viral CAP

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Flu vaccine recommendations

CDC recommends yearly for all over 6 months

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Antiviral Meds

Oseltamivir, Zanamivir, Peramivir, Baloxavir

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FDA EUA

The emergency of vaccine approval

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COVID MD

Treatment Non Hospitalized is dependent on severity

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Defense Mechanisms in Upper Airways

Nasal hair, turbinates, and IgA secretion help prevent pathogens from entering the lower respiratory tract.

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Defense Mechanisms in Conducting Airways

Including coughing and epiglottic reflexes, aid in clearing pathogens and preventing lower respiratory infections.

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Defense Mechanisms in Lower Airways

Including alveolar macrophages and immunoglobulin production, neutralize pathogens within the lung's air sacs.

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Impact of Host Defense Impairment

Impaired defenses allow organisms to bypass normal barriers and cause infection.

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Lifestyle Factors Affecting Pulmonary Defenses

Smoking disrupts mucociliary function, while alcohol impairs cough reflexes and increases aspiration risk.

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Underlying Conditions Affecting Pneumonia Risk

Including HIV, cystic fibrosis, and congenital defects, increase CAP susceptibility.

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Streptococcus pneumoniae

The most common bacterial cause of CAP, particularly in outpatient settings.

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Staphylococcus aureus in CAP

May require broader-spectrum antibiotics considering that the prevalence increases in inpatient and ICU settings.

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Common Viral Etiologies in CAP

Including influenza viruses, frequently cause pneumonia, especially in viral co-infections.

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Key Considerations For Treatment Selection

Severity, resistance patterns, and patient-specific factors like allergies and comorbidities guide selection.

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Empiric Antibiotics for CAP

Including fluoroquinolones or beta-lactam/macrolide combinations, target likely pathogens while considering resistance.

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IV-to-Oral Switch

switching involves assessing stability, ability to take oral medications, and normal Gl function.

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Longer antibiotic duration

For suspected CA-MRSA or Pseudomonas, a duration of 7 days is recommended due to the higher risk of invasive disease.

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Prevention and Treatment of Viral CAP

Annual vaccination against Influenza is recommended. Antivirals should be administered within 48 hours of symptom onset.

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Antiviral Medications

Including oseltamivir and zanamivir, reduce the severity and duration of influenza-related pneumonia.

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Community-Acquired Pneumonia (CAP) Definition

An infection of the lung parenchyma acquired outside a health setting, presenting with clinical or radiologic symptoms.

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Role of Physiologic Defense Mechanisms

Host mechanisms in the upper and lower respiratory tracts prevent CAP by clearing pathogens and initiating immune responses

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Influence of Risk factors on CAP Likelihood

Risk factors like advanced age and comorbidities raise the likelihood of CAP by weakening defense

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Factors Determining Appropriate CAP Treatment

Severity scores, IDSA/ATS criteria, hospitalization status, and existing guidelines all assist in proper treatment choice

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Treatment Approach in given condition

Guidelines, anti biograms and patient vitals all give key information about most effective treatments.

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What is Nasopharynx, Nasal hair, Turbinates, Mucociliary apparatus and IgA secretion

These are the upper airways which are used to defend against pathogens entering the body

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What is Cough, Epiglottic reflexes, Sharp-angled branching airways, Mucociliary apparatus and Airway surface liquid

These are the conducting airways that defend against pathogens entering the body

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What is Lower Respiratory Tract Defense

Including alveolar lining fluid and alveolar macrophages, protect the gas exchange

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What is Community-Acquired Pneumonia (CAP)

Acute infection of the pulmonary parenchyma that is acquired outside of the hospital/health-care setting

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What are the mortality rate of CAP

Mortality ranges from <1% to 50% depending on severity

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What are the Risk Factors for CAP

Older age and Chronic comorbidities are potential risk factors

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What is Clinical Presentation in CAP

Respiratory and Systemic findings can both indicate CAP

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What is the Diagnosis of CAP

The diagnosis of CAP consists of imaging and the signs & symptoms

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What is IDSA/ATS Severity Criteria

These are the criteria that help assess the severity of disease

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What factors affect CAP Regimen

Based on PSI or CURB-65, IDSA/ATS criteria

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What is a bacterial cause

Atypical organisms

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What is a type of CAP

Viral and Bacterial

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What is Viral CAP Prevention

Vaccination reduces risk and severity of viral CAP

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What is Alteration in consciousness

Compromised closure of the epiglottis

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What is Cigarette smoke

Disruption of mucociliary and macrophage activity

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What is Clinical Presentation in CAP

Respiratory and systemic findings indicate CAP

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What is CURB-65

Use this to determine the need of hospitalization.

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Study Notes

Lecture Objectives

  • Identify physiologic mechanisms of defense that play a role in community-acquired pneumonia (CAP).
  • Identify common organisms associated with CAP.
  • List risk factors that increase the likelihood of CAP.
  • List factors to consider for the selection of appropriate treatment of CAP.
  • List recommended treatments for CAP.
  • Select the most appropriate treatment for CAP based on a given case.

Host Defense Mechanisms in CAP

  • Host respiratory system defense mechanisms are crucial in preventing CAP.
  • The upper airways, including the nasopharynx and oropharynx, use nasal hair, turbinates, mucociliary apparatus, IgA secretion, saliva, sloughing of epithelial cells, cough, and complement production for defense.
  • Conducting airways (trachea, bronchi) use cough, epiglottic reflexes, sharp-angled branching airways, mucociliary apparatus, airway surface liquid, immunoglobulin production (IgG, IgM, IgA), dendritic cells, and bronchus-associated lymphoid tissue (BALT).
  • The lower respiratory tract (terminal airways, alveoli) utilizes alveolar lining fluid (surfactant, fibronectin, Ig, complement, free fatty acid, Fe-binding proteins), alveolar macrophages, neutrophils, dendritic cells, and bronchus-associated lymphoid tissue (BALT).

Impairment of Pulmonary Defenses

  • Pneumonias occur when host defenses are impaired, virulent organisms or large inoculum overwhelms defenses, colonization of the upper respiratory tract occurs, or hematogenous/iatrogenic spread takes place.
  • Alterations in levels of consciousness can compromise epiglottic closure, leading to aspiration of oropharyngeal flora.
  • Cigarette smoke disrupts mucociliary function and macrophage activity.
  • Alcohol impairs epiglottic and cough reflexes, is associated with increased colonization of oropharynx with aerobic Gram-negative bacilli, decreases mobilization of neutrophils, blocks TNF response to endotoxin, and enhances monocyte production of IL-10.
  • Mycoplasma pneumoniae or Haemophilus influenzae interfere with normal ciliary function.
  • Respiratory viruses destroy respiratory epithelium, disrupt normal ciliary activity, interfere with neutrophil function (chemotaxis, phagocytosis, oxidative metabolism), and inhibit alveolar macrophage function.
  • Sepsis from extrapulmonary infections undermines lung defense mechanisms.
  • HIV decreases quantitative and qualitative CD4 T-cell response, BALT dendritic cell and degeneration of lymphoid follicles, defective antigen-presenting cells, and abnormal chemotaxis, phagocytosis, oxidative metabolism.
  • Iatrogenic manipulation may interfere with usual host defenses and predispose to infection.
  • Medications like proton pump inhibitors and H2-blockers are associated with recurrent pneumonia.
  • Congenital defects and diseases (Young's syndrome, cystic fibrosis), myasthenia gravis, dementia, and esophageal reflux, strictures, diverticula predispose to aspiration.

Community-Acquired Pneumonia (CAP) Definition and Epidemiology

  • CAP is defined as an acute infection of the pulmonary parenchyma acquired outside of the hospital/health-care setting.
  • CAP is supported by clinical signs or symptoms, radiologic findings, or auscultatory findings.
  • In the United States, the incidence of CAP is 25 episodes per 10,000 adults, higher for older ages (65-79 years: 63 cases per 10,000 adults; ≥80 years: 164 cases per 10,000 adults).
  • Approximately 1.5 million hospitalizations per year and an estimated 10,000 deaths per year are due to CAP.
  • Mortality ranges from <1% to 50%, depending on severity.

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