Lec 11- Community-Acquired Pneumonia (CAP)

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Questions and Answers

Which of the following is a defense mechanism found in the upper airways?

  • Neutrophils
  • Alveolar macrophages
  • Dendritic cells
  • Nasal hair (correct)

IgA secretion is part of the host defense mechanisms in which location?

  • Bronchioles
  • Trachea
  • Alveoli
  • Nasopharynx (correct)

Which of the following mechanisms is a defense of the conducting airways?

  • IgA secretion
  • Alveolar macrophages
  • Cough (correct)
  • Complement production

Where are alveolar macrophages primarily located?

<p>Lower respiratory tract (D)</p> Signup and view all the answers

Which action impairs pulmonary defenses?

<p>Decreased mobilization of neutrophils (D)</p> Signup and view all the answers

According to the lecture, what can cigarette smoke disrupt when referring to pulmonary defenses?

<p>Disrupts mucociliary function and macrophage activity (B)</p> Signup and view all the answers

What is a typical effect of alcohol consumption on pulmonary defenses?

<p>Decreased mobilization of neutrophils (B)</p> Signup and view all the answers

What is a consequence of recurrent pneumonia listed in the lecture?

<p>Congenital defects and diseases (A)</p> Signup and view all the answers

What is Iatrogenic manipulation?

<p>Predispose to infection (D)</p> Signup and view all the answers

How is Community-Acquired Pneumonia (CAP) best defined?

<p>An acute infection of the pulmonary parenchyma acquired outside of the hospital. (D)</p> Signup and view all the answers

Compared to younger adults, what is the incidence of CAP in older adults?

<p>The incidence is higher. (A)</p> Signup and view all the answers

Per the lecture, what is the most common symptoms associated with CAP?

<p>Respiratory findings (A)</p> Signup and view all the answers

Besides a physical exam, what testing can be performed do diagnose CAP?

<p>Radiographic findings (A)</p> Signup and view all the answers

According to the lecture, what is one of the most common viral etiologies of CAP?

<p>Influenza virus (C)</p> Signup and view all the answers

How are CAP patients diagnosed?

<p>Signs and symptoms and radiographic evidence (B)</p> Signup and view all the answers

Patients are considered for empiric treatment if:

<p>They have pneumonia (D)</p> Signup and view all the answers

What is the time duration that empiric treatment should be ?

<p>5 days (B)</p> Signup and view all the answers

What should patients be treated for if suspected of MRSA or P. aeruginosa?

<p>7 days (D)</p> Signup and view all the answers

What determines if patients should be given empiric treatment? (Select all that may apply)

<p>The severity of the bacterial CAP (A)</p> Signup and view all the answers

What is a recommended therapy for influenza?

<p>Oseltamivir (A)</p> Signup and view all the answers

Which of the following is a risk factor for community-acquired pneumonia (CAP)?

<p>Older age (C)</p> Signup and view all the answers

Common bacterial organisms frequently associated with CAP include:

<p>Streptococcus pneumoniae (C)</p> Signup and view all the answers

A patient presents with cough, fever, and shortness of breath. Which additional finding would support a diagnosis of CAP?

<p>Radiologic findings (B)</p> Signup and view all the answers

Which of the following is a common clinical presentation for CAP?

<p>Lung sounds (D)</p> Signup and view all the answers

In the context of CAP, what is the primary goal when selecting an appropriate antibiotic?

<p>Targeting the most likely pathogen (D)</p> Signup and view all the answers

Which of the following should be considered for CAP?

<p>Patient allergies (A)</p> Signup and view all the answers

What is an atypical Bacteria that is linked to causing CAP?

<p>Legionella spp (B)</p> Signup and view all the answers

What is a risk factor for CAP?

<p>COPD (B)</p> Signup and view all the answers

What is a systemic finding for CAP?

<p>Fatigue (A)</p> Signup and view all the answers

Which drug is an anti-influenza medication?

<p>zanamivir (B)</p> Signup and view all the answers

What is not a characteristic that describes CAP?

<p>Not considered acute (C)</p> Signup and view all the answers

What are common gram-negative bacteria to be aware of?

<p>Klebsiella spp or Escherichia coli (C)</p> Signup and view all the answers

What is a rare bacterial infection that can be acquired with MERS-CoV?

<p>M. tuburculosis (A)</p> Signup and view all the answers

Which influenza vaccine is not for pregnant women?

<p>Live attenuated influenza vaccine (LAIV) (D)</p> Signup and view all the answers

Which is treatment for influenza and chemoprophylaxis?

<p>all of the above (D)</p> Signup and view all the answers

Which of the following is a component of the influenza vaccines?

<p>High dose hemagglutinin (C)</p> Signup and view all the answers

Which mechanism supports the diagnosis of CAP

<p>All of the above (D)</p> Signup and view all the answers

If prior tests show a positive MRSA result, what is the next step?

<p>Obtain cultures/nasal PCR, and add MRSA coverage: vancomycin or linezolid. (A)</p> Signup and view all the answers

What are the vaccines shown for COVID-19?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a function of turbinates in the upper airways?

<p>Filtering air (B)</p> Signup and view all the answers

In which part of the respiratory system is cough a defense mechanism?

<p>Conducting airways (D)</p> Signup and view all the answers

What type of cells are present in conducting airways?

<p>Dendritic cells (A)</p> Signup and view all the answers

What does the acronym BALT of the host defense mechanism stand for?

<p>Bronchus-associated lymphoid tissue (A)</p> Signup and view all the answers

What can colonization of the upper respiratory tract lead to?

<p>Pneumonia (D)</p> Signup and view all the answers

What condition does alcohol abuse compromise that would lead to ineffective pulmonary defense?

<p>Normal ciliary function (D)</p> Signup and view all the answers

What is a possible effect of respiratory viruses on pulmonary defenses?

<p>Inhibit alveolar macrophage function (C)</p> Signup and view all the answers

What action may predispose a patient to infection?

<p>Iatrogenic manipulation (C)</p> Signup and view all the answers

Which range represents the incidence of CAP found in older adults aged 65-79 years per 10,000?

<p>63 cases (C)</p> Signup and view all the answers

What is required to support the diagnosis of CAP?

<p>Clinical signs or symptoms (C)</p> Signup and view all the answers

According to the data, what percentage of Streptococcus pneumoniae cases are found in CAP?

<p>33-50% (A)</p> Signup and view all the answers

Which of the following best describes the definition of Community-Acquired Pneumonia (CAP)?

<p>Acute lung infection acquired outside of a hospital or healthcare setting (A)</p> Signup and view all the answers

Which of the following is a risk factor that increases the likelihood of CAP?

<p>Chronic comorbidities (B)</p> Signup and view all the answers

According to the lecture, what is a typical systemic sign for CAP

<p>Fatigue (B)</p> Signup and view all the answers

Which of the following has a 6-14% percentage in etiology of viral CAP?

<p>Influenza A and B viruses (D)</p> Signup and view all the answers

According to the lecture, what is the age restriction for the live attenuated influenza vaccine (LAIV)?

<p>2-49 years of age (D)</p> Signup and view all the answers

Which is a study done in CAP for Omandacycline?

<p>OPTIC (D)</p> Signup and view all the answers

What is the duration of treatment used when suspected of being proven with P. aeruginosa?

<p>7 days (B)</p> Signup and view all the answers

Which antiviral is given in the treatment of Chemoprophylaxis for treatment of influenza A and B

<p>Oseltamivir (C)</p> Signup and view all the answers

Which of the following vaccine does not recommend if there is a pregnancy?

<p>Live attenuated (C)</p> Signup and view all the answers

Which of the following correctly pairs a respiratory defense mechanism with its primary location in the respiratory system?

<p>Mucociliary apparatus - Conducting airways (trachea, bronchi) (B)</p> Signup and view all the answers

A patient with chronic alcohol use is more susceptible to pneumonia due to impaired pulmonary defenses. Which of the following mechanisms is most directly compromised by chronic alcohol consumption?

<p>Impairment of epiglottic and cough reflexes (D)</p> Signup and view all the answers

How does cigarette smoke impair pulmonary defenses, increasing the risk of community-acquired pneumonia (CAP)?

<p>By disrupting mucociliary function and macrophage activity (D)</p> Signup and view all the answers

Which of the following is a consequence of iatrogenic manipulation, such as endotracheal intubation, on pulmonary defense mechanisms?

<p>Interference with usual host defenses, predisposing to infection (D)</p> Signup and view all the answers

Community-Acquired Pneumonia (CAP) is best defined by its acquisition location. Which of the following scenarios best fits the definition of CAP?

<p>Pneumonia diagnosed in an outpatient setting in a previously healthy individual. (D)</p> Signup and view all the answers

Compared to younger adults, older adults have a significantly higher incidence of Community-Acquired Pneumonia (CAP). Which age group shows the highest incidence rate per 10,000 adults?

<p>Adults aged 80 years and older (C)</p> Signup and view all the answers

A patient presents with new onset cough, fever, and fatigue. Which of the following clinical findings, if present, would be MOST suggestive of Community-Acquired Pneumonia (CAP)?

<p>Localized rales or ronchi and dullness to percussion on chest examination (A)</p> Signup and view all the answers

Which of the following diagnostic approaches is essential to confirm a diagnosis of Community-Acquired Pneumonia (CAP) in a patient presenting with respiratory symptoms?

<p>Chest radiography or computed tomography (CT) (A)</p> Signup and view all the answers

According to guidelines, when is it appropriate to consider empiric antibiotic treatment for Community-Acquired Pneumonia (CAP)?

<p>When clinical and radiographic findings are consistent with pneumonia. (C)</p> Signup and view all the answers

For a previously healthy 33-year-old male diagnosed with outpatient Community-Acquired Pneumonia (CAP), and with no known drug allergies, which of the following is the MOST appropriate empiric antibiotic therapy?

<p>Oral Amoxicillin (A)</p> Signup and view all the answers

A 70-year-old patient with COPD is diagnosed with Community-Acquired Pneumonia (CAP) and is being treated as an outpatient. Which of the following antibiotic regimens would be MOST appropriate, considering their comorbidity?

<p>Levofloxacin monotherapy (A)</p> Signup and view all the answers

In a hospitalized patient with non-severe Community-Acquired Pneumonia (CAP), which of the following antibiotic strategies is generally recommended as a standard regimen?

<p>Combination therapy with a beta-lactam and a macrolide (B)</p> Signup and view all the answers

If a hospitalized patient with severe Community-Acquired Pneumonia (CAP) is suspected of having Pseudomonas aeruginosa as a causative pathogen, what adjustment should be made to the empiric antibiotic therapy?

<p>Add coverage for <em>Pseudomonas aeruginosa</em> with an agent like piperacillin/tazobactam. (D)</p> Signup and view all the answers

What is the recommended minimum duration of antibiotic therapy for Community-Acquired Pneumonia (CAP) in adults, assuming the patient is responding well to treatment and is without complications?

<p>5 days (C)</p> Signup and view all the answers

In the context of influenza prevention, which of the following influenza vaccines is generally contraindicated for pregnant women?

<p>Live attenuated influenza vaccine (LAIV) (C)</p> Signup and view all the answers

Which antiviral medication is approved for both the treatment and chemoprophylaxis of influenza A and B?

<p>Oseltamivir (C)</p> Signup and view all the answers

A patient with influenza is started on oseltamivir. Which of the following adverse effects is MOST commonly associated with oseltamivir?

<p>Nausea and vomiting (B)</p> Signup and view all the answers

According to the CURB-65 scoring system for pneumonia severity, which of the following criteria is assigned 1 point?

<p>Confusion (C)</p> Signup and view all the answers

Which of the following is a 'major criterion' for severe Community-Acquired Pneumonia (CAP) according to the IDSA/ATS severity criteria?

<p>Septic shock requiring vasopressors (B)</p> Signup and view all the answers

In the outpatient setting, when is blood or sputum Gram stain and culture generally recommended for the diagnosis of Community-Acquired Pneumonia (CAP)?

<p>Not routinely recommended. (D)</p> Signup and view all the answers

A patient is hospitalized with non-severe CAP and has a known prior respiratory isolation of MRSA. According to guidelines, what is the MOST appropriate initial step in managing their antibiotic therapy?

<p>Obtain cultures/nasal PCR and add MRSA coverage if positive. (B)</p> Signup and view all the answers

Which factor is LEAST likely to be considered when selecting an antibiotic regimen for Community-Acquired Pneumonia (CAP)?

<p>Patient's blood type (B)</p> Signup and view all the answers

A patient with Community-Acquired Pneumonia (CAP) is initially treated intravenously in the hospital. What criteria MUST be met before transitioning the patient to oral antibiotics for the remainder of their treatment?

<p>Patient is hemodynamically stable, clinically improving, and able to take oral medications. (D)</p> Signup and view all the answers

In the context of empiric antibiotic therapy for outpatient Community-Acquired Pneumonia (CAP), when is a macrolide (like azithromycin or clarithromycin) considered an appropriate monotherapy option?

<p>When local pneumococcal resistance rates are known to be &lt; 25%. (A)</p> Signup and view all the answers

Which of the following bacterial organisms is MOST commonly associated with Community-Acquired Pneumonia (CAP)?

<p><em>Streptococcus pneumoniae</em> (C)</p> Signup and view all the answers

A patient is diagnosed with influenza A and develops a secondary bacterial pneumonia. Which of the following bacterial organisms is MOST likely to be involved in this co-infection setting during an influenza epidemic?

<p><em>Staphylococcus aureus</em> (C)</p> Signup and view all the answers

Which influenza vaccine type is administered intranasally?

<p>Live attenuated influenza vaccine (LAIV) (D)</p> Signup and view all the answers

For which age group is the live attenuated influenza vaccine (LAIV) approved for use in individuals who are not pregnant and do not have chronic medical conditions?

<p>2–49 years of age (D)</p> Signup and view all the answers

Which of the following antivirals for influenza is administered intravenously (IV)?

<p>Peramivir (C)</p> Signup and view all the answers

For chemoprophylaxis of influenza post-exposure, which age group is approved for treatment with oseltamivir?

<p>≥ 3 months of age (C)</p> Signup and view all the answers

Which of the following is a potential risk associated with zanamivir, especially in patients with underlying airway disease?

<p>Bronchospasm (A)</p> Signup and view all the answers

Which newer antibiotic therapy for Community-Acquired Pneumonia (CAP) belongs to the aminomethylcycline class?

<p>Omadacycline (A)</p> Signup and view all the answers

Which of the following best describes the mechanism of action of baloxavir in treating influenza?

<p>Cap-dependent endonuclease inhibitor (D)</p> Signup and view all the answers

A patient with severe CAP requires combination antibiotic therapy. Which of the following is a guideline-recommended combination for empiric treatment?

<p>Ceftriaxone plus azithromycin (C)</p> Signup and view all the answers

Which of the following is a common systemic finding in a patient with Community-Acquired Pneumonia (CAP)?

<p>Tachycardia (C)</p> Signup and view all the answers

What is the primary goal when selecting an antibiotic for Community-Acquired Pneumonia (CAP)?

<p>To achieve adequate coverage of the most likely pathogens while minimizing resistance and side effects. (B)</p> Signup and view all the answers

Which of the following is considered an 'atypical' bacterium commonly associated with Community-Acquired Pneumonia (CAP)?

<p><em>Mycoplasma pneumoniae</em> (C)</p> Signup and view all the answers

Which of the following underlying conditions is considered a significant risk factor for Community-Acquired Pneumonia (CAP)?

<p>Chronic Obstructive Pulmonary Disease (COPD) (B)</p> Signup and view all the answers

In a patient with suspected Community-Acquired Pneumonia (CAP), which mechanism primarily supports the diagnosis, in addition to clinical findings?

<p>Radiographic evidence of pulmonary infiltrate (A)</p> Signup and view all the answers

If a patient's prior respiratory culture shows MRSA, and they develop Community-Acquired Pneumonia (CAP), what is the MOST appropriate next step in antibiotic management?

<p>Obtain current cultures and consider MRSA coverage if indicated. (A)</p> Signup and view all the answers

Which of the following is NOT a typical characteristic used to describe Community-Acquired Pneumonia (CAP)?

<p>Always caused by bacterial pathogens (B)</p> Signup and view all the answers

What is the approximate percentage of Community-Acquired Pneumonia (CAP) cases where a causative organism is NOT identified despite diagnostic efforts?

<p>40-60% (B)</p> Signup and view all the answers

Which component of the lower respiratory tract's host defense mechanism directly enhances phagocytosis and oxidative metabolism by neutrophils?

<p>Dendritic cells (C)</p> Signup and view all the answers

A patient with a history of intravenous drug use is admitted with CAP. Which mechanism is most likely to increase pneumonia risk?

<p>Altered mental status (B)</p> Signup and view all the answers

In an outbreak of gram-negative bacterial pneumonia, which of the following defense mechanisms is least effective?

<p>Lysozyme production (A)</p> Signup and view all the answers

A patient with a history of chronic alcohol abuse is diagnosed with CAP. Which of the following mechanisms contribute to their increased susceptibility?

<p>Impaired epiglottic and cough reflexes (A)</p> Signup and view all the answers

Considering the etiology of CAP, which of the following factors is LEAST likely to be associated with community-acquired pneumonia?

<p>Fungal infections (A)</p> Signup and view all the answers

Which of the following is the LEAST common cause of CAP in patients admitted to the Intensive Care Unit (ICU)?

<p><em>Mycoplasma pneumoniae</em> (A)</p> Signup and view all the answers

Several factors contribute to the likelihood of developing CAP. Which choice is least likely to be one of those factors?

<p>Frequent international travels (D)</p> Signup and view all the answers

A common symptom in patients presenting with CAP is fever, what percentage range is commonly seen with CAP?

<p>60% - 90% (A)</p> Signup and view all the answers

In the context of CAP diagnosis, what role do auscultatory findings such as rales, ronchi, and dullness on percussion play?

<p>They are supportive but nonspecific findings (A)</p> Signup and view all the answers

Radiographic findings are essential in the diagnosis of CAP. Which of the following is LEAST likely to be seen in an X-ray of a patient with CAP?

<p>Pneumothorax (C)</p> Signup and view all the answers

In bacterial CAP treatment, which of the following is the most important to consider when selecting an antibiotic?

<p>Most likely pathogens (D)</p> Signup and view all the answers

You are reviewing a patient's chart to determine the need for an antiviral drug. You see Oseltamivir, what route is it given?

<p>PO (D)</p> Signup and view all the answers

Which of the following would cause lower mobilization of neutrophils?

<p>Alcohol (A)</p> Signup and view all the answers

What statement BEST describes the purpose of the influenza vaccine?

<p>The vaccine contains hemagglutinin (HA) derived from viruses projected to be responsible for that year's season (B)</p> Signup and view all the answers

The data for SARS-CoV-2(COVID-19) vaccines are still being reviewed. What is vital in order to approve the vaccine?

<p>Safe and effective (A)</p> Signup and view all the answers

A 68-year-old patient is admitted to the hospital with CAP. Based on the IDSA/ATS criteria, which of the following findings would be considered a major criterion for severe CAP?

<p>Septic shock with need for vasopressors (B)</p> Signup and view all the answers

The influenza vaccines are composed of which of the following to help treat a variety of strains?

<p>Quadrivalent (D)</p> Signup and view all the answers

What are the ages for treatment of Zanamivir?

<p>Greater than 7 years (B)</p> Signup and view all the answers

For adults with CAP, under which oxygen saturation (O2Sat) should they be switched from IV to PO?

<p>No specific O2Sat is required (B)</p> Signup and view all the answers

A 57 year old male is diagnosed with influenza A. He only has mild symptoms and has been diagnosed within the last 24 hours. What type of medication would be beneficial for someone who also has underlying airway disease?

<p>Oseltamivir (C)</p> Signup and view all the answers

Which of the following is a primary mechanism by which alveolar lining fluid contributes to host defense in the lower respiratory tract?

<p>Enhancing phagocytosis and oxidative metabolism by neutrophils. (A)</p> Signup and view all the answers

How does alcohol consumption impair epiglottic and cough reflexes, increasing the risk of CAP?

<p>By compromising the ability to protect the lower airways from aspiration. (B)</p> Signup and view all the answers

A 45-year-old patient with a history of intravenous drug use is diagnosed with CAP. Which of the following mechanisms most likely increases the risk of pneumonia in this patient population?

<p>Compromised cough receptors and reduced effectiveness of the cough reflex (A)</p> Signup and view all the answers

A patient is hospitalized with CAP and has a documented penicillin allergy. The local antibiogram shows a high rate of macrolide resistance in Streptococcus pneumoniae. Which factor should the clinician consider?

<p>The potential for adverse drug interactions, especially with QT-prolonging agents. (C)</p> Signup and view all the answers

A 68-year-old patient with congestive heart failure (CHF) is diagnosed with CAP. Considering the patient's comorbidity, which of the following antibiotic regimens would be MOST appropriate for outpatient treatment?

<p>Amoxicillin/clavulanate combined with azithromycin, for broad-spectrum coverage. (C)</p> Signup and view all the answers

A 72-year-old patient is admitted to the hospital with severe CAP. The patient has a history of MRSA colonization but no prior respiratory isolation. According to guidelines, what is the MOST appropriate initial step in antibiotic management?

<p>Start cultures, and MRSA coverage vancomycin or linezolid. (D)</p> Signup and view all the answers

According to IDSA/ATS guidelines, a patient with CAP would be classified as having 'severe' disease if they exhibit which of the following?

<p>Respiratory failure that requires mechanical ventilation. (B)</p> Signup and view all the answers

Which of the following statements best describes the primary goal of antibiotic selection for bacterial Community-Acquired Pneumonia (CAP)?

<p>Improve patient symptoms, shorten the duration of illness, and prevent complications. (A)</p> Signup and view all the answers

In a patient with CAP, which common systemic finding is least likely to be directly associated with the severity or prognosis of the pneumonia itself?

<p>The patient's blood Glucose of 130 mg/dL. (D)</p> Signup and view all the answers

Considering the risk factors for CAP, which of the following environmental factors is least likely to significantly increase the incidence of CAP in a community?

<p>Living in a single-family home with a large yard and a high altitude. (B)</p> Signup and view all the answers

In the context of bacterial co-infections during influenza epidemics, which bacterial organism is MOST likely to be involved in causing secondary pneumonia?

<p><em>Haemophilus influenzae</em> (C)</p> Signup and view all the answers

What is the MOST significant advantage of using amoxicillin/clavulanate combined with azithromycin for the treatment of CAP in a patient with co-morbid conditions such as COPD or diabetes?

<p>Targeting of both typical and atypical bacteria. (B)</p> Signup and view all the answers

Following the isolation and identification of the causative pathogen in a patient with CAP, the decision to transition a patient from intravenous (IV) to oral (PO) antibiotics should be based on multiple factors. Which of the following considerations is least relevant when making this decision?

<p>The availability of two forms of the same intravenous antibiotics. (B)</p> Signup and view all the answers

When considering the use of Zanamivir for influenza, under what conditions would it be most appropriate to avoid prescribing this medication?

<p>When the patient is being treated for influenza A or B and is younger than 7 years old. (C)</p> Signup and view all the answers

A patient presents with CAP symptoms, and the physician suspects Legionella as the possible causative organism due to a recent community outbreak. Which of the following options would be the most appropriate treatment?

<p>Prescribing a macrolide or fluoroquinolone to target intracellular bacteria. (A)</p> Signup and view all the answers

What is the primary rationale behind using combination antibiotic therapy for the treatment of severe CAP?

<p>Provide antimicrobial coverage for a broader range of potential bacterial pathogen to start treatment. (A)</p> Signup and view all the answers

What is the key consideration when prescribing Tamiflu (Oseltamivir) for the treatment or chemoprophylaxis of influenza?

<p>Starting treatment early in the course of illness. (C)</p> Signup and view all the answers

A patient is diagnosed with CAP and has a history of non-meningitis breakpoint/meningitis breakpoint infections. What is the significance of monitoring the two years of data for S. pneumoniae prior treatment?

<p>Selecting an antimicrobial treatment to determine sensitivity rate. (C)</p> Signup and view all the answers

What is the significance of balancing potential risks and benefits based on best-available evidence, when using EUA compared to the FDA approval process?

<p>Determining whether the product can be used during the emergency while under an incomplete FDA approval process. (C)</p> Signup and view all the answers

Under what circumstance is Remdesivir an acceptable form of treatment of COVID-19?

<p>In a non-hospitalized setting that isn’t requiring oxygen with an alternative option. (B)</p> Signup and view all the answers

Which influenza vaccine is a contraindication to a patient that states they have an anti-influenza medication intake within the past 48 hours?

<p>Live attenuated (LAIV). (B)</p> Signup and view all the answers

When there is a lesion in the left lung in a patient diagnosed with CAP, which is the most likely symptom to have?

<p>Crackles at the site of consolidation and/or dullness on percussion. (B)</p> Signup and view all the answers

A patient reports for a COVID-19 vaccination. Which steps must the pharmacist consider?

<p>Know the product and best available evidence to proceed with treatment. (A)</p> Signup and view all the answers

When selecting what empiric therapy would be BEST for an outpatient with no comorbidities, which would have pneumococcal resistance of <25%?

<p>Azithromycin. (B)</p> Signup and view all the answers

For hospitalized patients, which of the following antibiotics need to be taken, as needed, depending on the validated local risk?

<p>MRSA, be deescalating or discontinuing based on PCR or cultures. (D)</p> Signup and view all the answers

According to data provided, how does COVID-19 impact the respiratory system.

<p>Very few patients have a bacterial infection with M. pneumoniae and H. influenzae. (B)</p> Signup and view all the answers

If a 62 year old patient only has mild symptoms, how long is the treatment after being diagnosed?

<p>5 days (C)</p> Signup and view all the answers

An asthma patient is diagnosed with Influenza, which Antiviral would you be careful with?

<p>Zanamivir. (A)</p> Signup and view all the answers

A 33-year-old male is diagnosed with presumptive CAP at an outpatient clinic. He has no known allergies and no significant history of any conditions but never taken antibiotics before. After evaluation, which medication would the male LEAST likely be prescribed to treat his CAP?

<p>Methicillin-resistant Staphylococcus aureus (MRSA) (D)</p> Signup and view all the answers

Which of the following antibiotics, when used for CAP treatment, requires caution and monitoring for QT-prolongation?

<p>Azithromycin. (C)</p> Signup and view all the answers

A patient with severe influenza is treated with Baloxavir. What is the primary mechanism of action of Baloxavir?

<p>Interfering with viral RNA replication. (A)</p> Signup and view all the answers

What is the earliest time after influenza exposure when Oseltamivir can be given for chemoprophylaxis?

<p>For individuals aged 3 months and older, post-exposure. (B)</p> Signup and view all the answers

Which diagnostic procedure could be performed for CAP?

<p>Auscultatory findings. (A)</p> Signup and view all the answers

How does altered lung clearance of bacteria due to lipopolysaccharide or endotoxin typically contribute to the impairment of pulmonary defenses?

<p>It decreases the immune system. (D)</p> Signup and view all the answers

A post COVID diagnosed ICU patient requires broad spectrum antibiotics, why?

<p>ICU patients easily aquire antibiotic resistant pneumonia bacteria. (A)</p> Signup and view all the answers

A 33 year old makes a new diagnosis and the physician knows its CAP, what questions could be asked to determine?

<p>Have you had recent history with influenza viral infections?. (A)</p> Signup and view all the answers

What is a key recommendation the panel gives about giving dexamethasone to COVID patients?

<p>They recommend to not use with any other indications. (D)</p> Signup and view all the answers

Which is the most used vaccine?

<p>Administered intramuscular by inactivated influenza subunit vaccines. (B)</p> Signup and view all the answers

For confirmed and validated resistance, what may ensue?

<p>Try a different combination of antibiotic due to resistance. (A)</p> Signup and view all the answers

Which defense mechanism can be compromised during alcohol intoxication, potentially leading to aspiration of oropharyngeal flora?

<p>Epiglottic closure and cough reflexes (D)</p> Signup and view all the answers

In the pathophysiology of CAP, which of the following scenarios would MOST likely lead to pneumonia development due to overwhelming host defenses?

<p>Inoculation with a low dose of a highly virulent strain of influenza (A)</p> Signup and view all the answers

A patient with a history of recurrent aspiration pneumonia is found to have decreased dendritic cell function. How does this impairment increase the risk of pneumonia?

<p>Defective antigen-presenting cell activity in the BALT (A)</p> Signup and view all the answers

Which of the following factors is LEAST likely to influence the selection of an empiric antibiotic regimen for a patient with CAP?

<p>Patient's history of adherence to previous medication regimens (D)</p> Signup and view all the answers

What is the MOST important factor in the clinical decision to switch a patient from intravenous (IV) to oral (PO) antibiotics when treating CAP?

<p>Ability to tolerate and absorb oral medication (B)</p> Signup and view all the answers

What is the rationale for recommending empiric antibiotic treatment that expands coverage to include beta-lactam/beta-lactamase inhibitors for a CAP patient with chronic Haemophilus influenzae?

<p>To overcome potential resistance mechanisms of <em>H. influenzae</em> (B)</p> Signup and view all the answers

A patient with a known history of severe COPD requires hospitalization for CAP. Which recommended course of antibiotics must be avoided?

<p>Clarithromycin (C)</p> Signup and view all the answers

If the local antibiogram in a certain area of the United States indicates that Streptococcus pneumoniae has decreased pneumococcal resistance of >25%, which medication would be considered?

<p>Levofloxacin (B)</p> Signup and view all the answers

A patient who took anti-influenza medication within the last 48 hours reports for a vaccination, which vaccine would require a second thought?

<p>Live attenuated influenza vaccine (LAIV) (D)</p> Signup and view all the answers

A patient reports for a influenza vaccination and has a severe allergy to eggs. Which vaccinations would be considered?

<p>Recombinant (RIV) (B)</p> Signup and view all the answers

When considering a patient is on Oseltamivir, which adverse event can occur?

<p>Vomiting (C)</p> Signup and view all the answers

Which of the following factors is LEAST likely to be considered in antimicrobial agents?

<p>Local Antibiotic Resistance Patterns (A)</p> Signup and view all the answers

For influenza A and B, the time frame for it to be taken by the patient is ideally 48 hours, what kind of action would that trigger?

<p>Treatment and Chemoprophylaxis (A)</p> Signup and view all the answers

Which of the following is NOT a component of the traditional vaccine approval process?

<p>EUA Implementation (B)</p> Signup and view all the answers

During a potential life-threatening disease, what process is completed to obtain vaccine implementation?

<p>EUA Implementation (B)</p> Signup and view all the answers

Which mechanism is least likely to be associated with community-acquired pneumonia?

<p>Pre existing Lung Tumors (A)</p> Signup and view all the answers

A patient is intubated with diagnosed CAP. The physician is considering administering antibiotics. What is the next step?

<p>Blood and sputum gram-stain (A)</p> Signup and view all the answers

Which factor should be taken in consideration when choosing whether to use an Anti-MRSA?

<p>Validated local risk (C)</p> Signup and view all the answers

A patient has been diagnosed with CAP in the trachea? Why is the Epiglottic Reflexes Important?

<p>The gag reflex to limit aspiration of contents to the tracheal airway (B)</p> Signup and view all the answers

Why should a Physician be cautious of a patient with cough, fever, and lung crackles with COVID-19? (Select all that apply)

<p>The patient with COVID-19 may cause the patient to have bacterial super imposed infection (D)</p> Signup and view all the answers

Which of the following is a physiological defense mechanism present in the lower respiratory tract?

<p>Alveolar macrophages (B)</p> Signup and view all the answers

Which of the following organisms is most commonly associated with Community-Acquired Pneumonia (CAP) in adults?

<p>Streptococcus pneumoniae (C)</p> Signup and view all the answers

Which of the following best describes a risk factor that increases the likelihood of developing Community-Acquired Pneumonia (CAP)?

<p>Chronic lung disease (B)</p> Signup and view all the answers

Which of the following factors should be considered when selecting the most appropriate antibiotic treatment for Community-Acquired Pneumonia (CAP)?

<p>Local resistance patterns (B)</p> Signup and view all the answers

Which of the following is considered a recommended treatment option for Community-Acquired Pneumonia (CAP) in previously healthy adults?

<p>Monotherapy with a fluoroquinolone (A)</p> Signup and view all the answers

What constitutes a 'major criterion' for severe Community-Acquired Pneumonia (CAP) according to the IDSA/ATS severity criteria?

<p>Septic shock with the need for vasopressors (C)</p> Signup and view all the answers

Which statement about switching from intravenous (IV) to oral (PO) antibiotics for CAP treatment is mostaccurate?

<p>The switch is appropriate when the patient is hemodynamically stable and improving clinically (C)</p> Signup and view all the answers

Which of the following is a newer antibiotic therapy for Community-Acquired Pneumonia (CAP) that belongs to the aminomethylcycline class?

<p>Omadacycline (D)</p> Signup and view all the answers

A previously healthy 33-year-old male is diagnosed with outpatient Community-Acquired Pneumonia (CAP), and with no known drug allergies, which of the following is the MOST appropriate empiric antibiotic therapy?

<p>Amoxicillin (D)</p> Signup and view all the answers

A patient with severe influenza is being considered for treatment with Baloxavir. What is the primary mechanism of action of Baloxavir?

<p>Inhibition of the cap-dependent endonuclease (C)</p> Signup and view all the answers

When there is a COVID-19 diagnoses, where is the most likely place that would have lung effects?

<p>Lung Parenchyma and Alveoli (B)</p> Signup and view all the answers

Which route is used for Peramivir?

<p>IV (C)</p> Signup and view all the answers

What should be given to patients non-hospitalized?

<p>None of the above (D)</p> Signup and view all the answers

A factor that can be considered when choosing treatment is?

<p>Formulary and Cost (D)</p> Signup and view all the answers

The traditional vaccine has which step?

<p>Expert recommendation on vaccine use (B)</p> Signup and view all the answers

What is one step included in EUA?

<p>FDA reviews best available evidence (C)</p> Signup and view all the answers

The influenza vaccines contain which of the following:

<p>Viruses projected to be responsible for that year's season (B)</p> Signup and view all the answers

A patient had a known exposure to the flu from his daughter. He asks how long after exposure can he take Oseltamivir for Chemoprophylaxis?

<p>24 hours (C)</p> Signup and view all the answers

A 33-year-old male is diagnosed with presumptive CAP at an outpatient clinic. He has no known allergies and no significant medical history. Based on the example outpatient antibiogram, if the local pneumococcal resistance is >25%, which single antibiotic should the male MOST likely be prescribed to treat his CAP?

<p>Levofloxacin (D)</p> Signup and view all the answers

A 33-year-old male is diagnosed with presumptive CAP at an outpatient clinic. He has no known allergies and no significant medical history but never taken antibiotics before. After evaluation, which medication would the male LEAST likely be prescribed to treat his CAP?

<p>Ciprofloxacin (A)</p> Signup and view all the answers

According to guidelines, acute bacterial pneumonia in adults should be treated with antibiotics to cover typical bacterial pathogens based on local resistance patterns. What duration of antibiotic usage is recommended?

<p>Minimum duration of 5 days (D)</p> Signup and view all the answers

Within 48 hrs. a patient reports for vaccinations. He advises that he took an anti-influenza medication, what vaccines would the patient need to reconsider?

<p>Live attenuated influenza vaccine (C)</p> Signup and view all the answers

What would be the LEAST likely cause of Community-Acquired Pneumonia (CAP)?

<p>Being in the ICU (B)</p> Signup and view all the answers

A patient is prescribed erythromycin for their pneumonia, what is important to consider?

<p>QT-Prolongation (A)</p> Signup and view all the answers

What does severity of disease depend on?

<p>Whether to treat as Outpatient vs Inpatient (A)</p> Signup and view all the answers

What can the clinician use to determine what antibiotic they should prescribe based on organisms?

<p>PSI and Curb-65 IDSA Score (D)</p> Signup and view all the answers

There is data that provides monitoring and prevention of S. pneumoniae. How many years should this data be monitored?

<p>2 Years (D)</p> Signup and view all the answers

A patient is in the hospital already being treated with IV Antibiotics, when is it important to determine additional steps for the patient?

<p>Once there is severe CAP (C)</p> Signup and view all the answers

Peramivir is approved for patients at what age?

<p>6 months (B)</p> Signup and view all the answers

A patients test comes back for an elevated D-Dimer, what is necessary?

<p>Therapeutic Dose of Heparin (D)</p> Signup and view all the answers

When should adults be moved from IV to PO treatment for O2 saturation?

<p>O2Sat &gt; 90% (C)</p> Signup and view all the answers

What is the main goal for vaccines under the Traditional Approval Process for implementation?

<p>Safe and Effect (C)</p> Signup and view all the answers

A patient that receives an antiInfluenza, has a contraindication to what vaccines.

<p>LaiV (B)</p> Signup and view all the answers

How to reduce risk Factors with COVID-19?

<p>Wearing a mask (D)</p> Signup and view all the answers

Which defense mechanism is present only in the conducting airways?

<p>Sharp-angled branching airways (D)</p> Signup and view all the answers

In bacterial co-pneumonia, what typically occurs during influenza epidemics?

<p>Atypical bacteria (A)</p> Signup and view all the answers

In a patient diagnosed with CAP, what is the purpose of knowing why the epiglottic reflexes?

<p>To prevent the spread to the trachea (C)</p> Signup and view all the answers

Which is the recommendation when giving COVID-19 vaccine boosters?

<p>Yearly (B)</p> Signup and view all the answers

Which component of the upper airways functions as a host defense mechanism?

<p>Mucociliary apparatus (D)</p> Signup and view all the answers

Which immune component is produced in the oropharynx as a host defense mechanism?

<p>Complement (A)</p> Signup and view all the answers

What is the function of sharp-angled branching in conducting airways?

<p>Impede the entry of large particles (D)</p> Signup and view all the answers

Which of the following is a known cause for the occurrence of pneumonia?

<p>Impairment of pulmonary defenses (C)</p> Signup and view all the answers

How does cigarette smoke impair pulmonary defenses?

<p>By disrupting mucociliary function (B)</p> Signup and view all the answers

Which of the following conditions is LEAST likely to impair epiglottic closure, potentially leading to aspiration?

<p>Normal sleep (D)</p> Signup and view all the answers

How does HIV infection impair pulmonary defenses contributing to CAP?

<p>Decreased dendritic cell activity (B)</p> Signup and view all the answers

What is the definition of community-acquired pneumonia (CAP)?

<p>Pneumonia acquired outside of a hospital (C)</p> Signup and view all the answers

What characteristic is commonly associated with CAP?

<p>Presence of clinical signs/symptoms (C)</p> Signup and view all the answers

What percentage would be given for the average mortality rate for CAP?

<p>Ranges from &lt;1% to 50% depending on severity (D)</p> Signup and view all the answers

What is a common viral cause of community-acquired pneumonia (CAP)?

<p>Influenza virus (D)</p> Signup and view all the answers

Which of the following is the LEAST likely organism causing his CAP, given that the patient is a 33 yo male diagnosed with presumptive CAP at an outpatient clinic, with no known allergies and no significant history for any conditions, however, they do have a 10-year history of smoking 1 ppd and weekend EtOH binge with friends, and has not received flu vaccine this year, and never taken antibiotics?

<p>Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) (C)</p> Signup and view all the answers

A patient with CAP presents with a fever, which is seen with what range:

<p>60%-90% (A)</p> Signup and view all the answers

Which factor is critical when selecting a drug regimen for confirmed legionella?

<p>Macrolide or fluoroquinolone (A)</p> Signup and view all the answers

The results show a gram stain, but there are concerns of risk for resistant orgnanisms, what is required?

<p>Blood or sputum Gram stain and culture (A)</p> Signup and view all the answers

Which influenza vaccine is appropriate to administer to individuals the age of 50 and up?

<p>Inactivated influenza Vaccine (IIV) (B)</p> Signup and view all the answers

What is the recommended treatment for confirmed patients with P. aeruginosa?

<p>7 days (D)</p> Signup and view all the answers

Which of the following is a risk factor that increases the likelihood of developing Community-Acquired Pneumonia (CAP)?

<p>Chronic comorbidities (B)</p> Signup and view all the answers

When should a treatment should be intitated?

<p>Ideally within 48 hours since onset of illness (C)</p> Signup and view all the answers

Why should there be caution with prescribing Zanamivir to asthma patients?

<p>Zanamivir can trigger broncho spasm (C)</p> Signup and view all the answers

Flashcards

Upper airway defenses

Defense mechanisms in the upper airways include nasal hair, turbinates, mucociliary apparatus, and IgA secretion.

Conducting airway defenses

Defense mechanisms in the conducting airways (trachea, bronchi) include cough, epiglottic reflexes, sharp-angled branching airways, mucociliary apparatus, airway surface liquid, immunoglobulin production (IgG, IgM, IgA), dendritic cells, and bronchus-associated lymphoid tissue (BALT).

Lower respiratory tract defenses

Defense mechanisms in the lower respiratory tract (terminal airways, alveoli) include alveolar lining fluid (surfactant, fibronectin, Ig, complement, free fatty acid, Fe-binding proteins), alveolar macrophages, neutrophils, dendritic cells, and bronchus-associated lymphoid tissue (BALT).

Causes of Pneumonia

Pneumonias occur due to impairment of host defenses, virulent organisms overwhelming host defenses, colonization of the upper respiratory tract, or hematogenous or iatrogenic spread.

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Compromised pulmonary defenses

Alterations in consciousness, cigarette smoke, and alcohol impair pulmonary defenses.

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More compromised pulmonary defenses

Sepsis, HIV, iatrogenic manipulation (intubation), medications(PPIs), congenital defects (cystic fibrosis), myasthenia gravis, dementia, and esophageal reflux can impair pulmonary defenses.

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Community-Acquired Pneumonia definition

CAP is defined as an acute infection of the pulmonary parenchyma acquired outside the hospital/health-care setting, supported by clinical, radiologic, or auscultatory findings

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CAP Risk Factors

Common risk factors for CAP include older age (especially ≥65), chronic comorbidities (COPD, heart disease, etc.), viral respiratory infections, impaired airway protection, smoking/alcohol abuse, and crowded living conditions.

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Typical CAP Bacteria

Typical bacterial causes of CAP are Streptococcus pneumoniae (most common), Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus.

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Atypical CAP Bacteria

Atypical bacterial causes of CAP include Legionella spp, Mycoplasma pneumoniae, Chlamydia pneumoniae, Chlamydia psittaci and Coxiella burnetii.

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Viral Causes of CAP

Respiratory viral causes of CAP include Coronaviruses, Influenza A and B viruses, Rhinoviruses, Respiratory syncytial virus (RSV), Human metapneumovirus, Parainfluenza viruses, Adenoviruses and Human bocaviruses.

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CAP Clinical Presentation

Respiratory findings in CAP include cough, sputum production, dyspnea, and chest discomfort. Systemic findings include fatigue, sweats, headache, nausea, myalgia, fever, chills/rigors, and tachycardia.

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CAP Diagnosis

In CAP, compatible clinical syndrome and imaging are needed for diagnosis

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CAP Severity assessment

In CAP, severity can be assessed using CURB-65 or PSI scoring

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More about CAP severity assessment

Severity in CAP can be also defined with IDSA/ATS minor and major criteria.

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Factors to consider in CAP treatment

Factors to consider in CAP treatment: severity, likely pathogens, clinical experience, cost, antibiotic characteristics, and patient-specific factors

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CAP treatment for outpatients

Empiric antibiotic therapy for adult outpatients with no comorbidities covers amoxicillin, doxycycline or macrolides when local pneumococcal resistance is <25%.

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Influenza vaccines

Choice of influenza vaccines include Inactivated influenza vaccine (IIV), Recombinant influenza vaccine (RIV), and Live attenuated influenza vaccine (LAIV).

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COVID-19 NOT recommended

Therapies to be avoided includes dexamethasone in the treatment of COVID-19

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CAP defenses

The physiological mechanisms of defense in CAP involve upper airways, conducting airways, and lower respiratory tract defenses.

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Common CAP organisms

Common organisms include Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae etc. which can be bacterial or viral agents.

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CAP Treatment factors

Selection factors include severity, likely pathogens, local resistance patterns, patient allergies, and comorbidities.

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Bacterial CAP treatments

Recommended treatments for bacterial CAP include beta-lactams, macrolides, doxycycline, or fluoroquinolones, depending on patient factors and local resistance.

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CAP treatment selection

Selection of treatment for CAP involves considering the most appropriate antibiotic therapy as guided by guidelines based on the patient-specific factors.

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Alcohol & Smoking compromise

Smoking and alcohol compromise mucociliary function and macrophage activity, impairing the clearance of pathogens.

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CAP radiographic findings

Radiographic findings like lobar consolidation, interstitial infiltrates, or cavitations, aid in CAP diagnosis.

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CURB-65

CURB-65 assesses confusion, urea, respiratory rate, blood pressure, and age to determine pneumonia severity.

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IDSA/ATS minor criteria

IDSA/ATS minor criteria include respiratory rate, PaO2/FIO2 ratio, multilobar infiltrates, confusion, uremia, leukopenia, thrombocytopenia, hypothermia, and hypotension.

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IDSA/ATS major criteria

IDSA/ATS major criteria are septic shock needing vasopressors and respiratory failure needing mechanical ventilation.

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CAP pathogen tests

Pathogen-specific tests, like cultures or PCR, are recommended for inpatients to identify the causative organism.

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Drugs regimen in CAP

Severity, most likely pathogens, clinical experience/evidence considerations when selecting a drug regimen for CAP.

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CAP inpatient Antibiotics

For Inpatients patients without MRSA or pseudomonas risk treated with beta-lactam + macrolide or respiratory fluoroquinolone.

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Influenza complications

Recommended to take the influenza vaccine annually for people at high risk for complications from flu.

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Zanamivir

Zanamivir is used for Influenza A and B Treatment Chemoprophylaxis, but with risk of bronchospasm

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Baloxavir

Baloxavir is a PO to treat Influenza A and B, in 1 day dose.

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Physiologic defenses in CAP

Physiologic mechanisms of defense include the respiratory system's barriers and immune responses.

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What is Community-Acquired Pneumonia (CAP)?

These are acute infections acquired outside of hospitals, often presented with a cough

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Cultures for uncomplicated CAP?

In outpatient settings, sputum or blood cultures are typically not necessary.

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Switching from IV to PO antibiotics

Considerations when transitioning from IV to oral antibiotics include hemodynamic stability, clinical improvement, ability to take oral medications, and a functional GI tract.

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CAP treatment duration

The standard treatment length of CAP is 5 days.

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How to select CAP treatment

Factors include patient comorbidities, risk factors for resistant organisms, and local antibiotic resistance patterns

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Preventing viral CAP

Universal vaccination annually for influenza

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contents of flu vaccines?

The flu vaccine's contents are hemagglutinin and are derived from viruses

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Treatments for COVID-19

COVID-19 treatments such as Ritonavir-boosted nirmatrelvir and Remdesivir are often taken

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Who SHOULDN'T be taking the vaccine?

The flu vaccine is not recommended for those with pregnancy

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Physiologic defense mechanisms in CAP

Defense mechanisms work in the upper airways, conducting airways and the lower respiratory tract.

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Common pneumonia organisms

Includes common bacteria, atypical bacteria, and/or respiratory viruses

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Risk factors for CAP likelihood

Older age, smoking, alcohol abuse, comorbidities, and immunosuppression.

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Factors to consider for treatment selection

Severity, risk factors, and potential drug interactions.

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Recommended CAP Treatments

Adult outpatient, inpatient non-severe, and inpatient severe treatments

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Study Notes

Lecture Objectives

  • Identify the physiologic mechanisms of defense that play a role in Community-Acquired Pneumonia (CAP).
  • Identify common organisms associated with Community-Acquired Pneumonia.
  • List risk factors that increase the likelihood of Community-Acquired Pneumonia.
  • Determine what factors to consider for the selection of appropriate treatment of Community-Acquired Pneumonia.
  • Note the recommended treatments for Community-Acquired Pneumonia.
  • Select the most appropriate treatment for a Community-Acquired Pneumonia case.

Host Respiratory System Defense Mechanisms

  • Upper airways:
    • Nasopharynx: includes nasal hair, turbinates, mucociliary apparatus, and IgA secretion.
    • Oropharynx: contains saliva, sloughing of epithelial cells, cough, and complement production.
  • Conducting airways (trachea, bronchi):
    • Include cough, epiglottic reflexes, sharp-angled branching airways, mucociliary apparatus, airway surface liquid, immunoglobulin production (IgG, IgM, IgA), dendritic cells, and bronchus-associated lymphoid tissue (BALT).
  • Lower respiratory tract (terminal airways, alveoli):
    • Includes alveolar lining fluid (surfactant, fibronectin, Ig, complement, free fatty acid, Fe-binding proteins), alveolar macrophages, neutrophils, dendritic cells, and bronchus-associated lymphoid tissue (BALT).

Causes of Pneumonia

  • Pneumonias occur due to an impairment of host defenses.
  • Virulent organisms or a large inoculum overwhelms host defenses.
  • Colonization of the upper respiratory tract.
  • Hematogenous or iatrogenic spread.

Impairment of Pulmonary Defenses

  • Alteration in levels of consciousness can compromise epiglottic closure, leading to aspiration of oropharyngeal flora (stroke, seizures, drug intoxication, alcohol abuse, normal sleep).
  • Cigarette smoke disrupts mucociliary function and macrophage activity.
  • Alcohol impairs epiglottic and cough reflexes, is associated with increased colonization of the oropharynx with aerobic Gram-negative bacilli, decreases mobilization of neutrophils, blocks TNF response to endotoxin, and enhances monocyte production of IL-10.
  • Mycoplasma pneumoniae or Haemophilus influenzae interfere with normal ciliary function.
  • Respiratory viruses destroy respiratory epithelium, disrupt normal ciliary activity, interfere with neutrophil function (chemotaxis, phagocytosis, oxidative metabolism), and inhibit alveolar macrophage function.
  • Sepsis from extrapulmonary infections undermines lung defense mechanisms; in animal models, lipopolysaccharide or endotoxin decreases lung clearance of bacteria.
  • Human Immunodeficiency Virus (HIV) causes a decreased quantitative and qualitative CD4 T-cell response, BALT dendritic cell and degeneration of lymphoid follicles, defective antigen-presenting cells, and abnormal chemotaxis, phagocytosis, and oxidative metabolism.
  • Iatrogenic manipulation interferes with usual host defenses and predisposes to infection (endotracheal tubes, nasogastric tubes, respiratory therapy equipment).
  • Medications: proton pump inhibitors and H2-blockers.
  • Congenital defects and diseases (Young’s syndrome, cystic fibrosis).
  • Myasthenia gravis, dementia; esophageal reflux, strictures, diverticula predispose to aspiration.

Community-Acquired Pneumonia (CAP)

  • An acute infection of the pulmonary parenchyma acquired outside of the hospital/health-care setting.
  • It is supported by clinical signs or symptoms, radiologic findings, or auscultatory findings.

Epidemiology of CAP (United States)

  • Incidence: 25 episodes per 10,000 adults.
    • Higher for older adults.
      • 65–79 years: 63 cases per 10,000 adults.
      • ≥80 years: 164 cases per 10,000 adults.
  • Estimated 1.5 million hospitalizations per year due to CAP
  • Estimated 10,000 deaths per year.
  • Mortality ranges from <1% to 50% depending on severity.

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