Podcast
Questions and Answers
What is the definition of anticancer agents?
What is the definition of anticancer agents?
- Drugs used to treat cancer or neoplastic disease (correct)
- Agents that target tumorigenic molecules
- Drugs that induce multidrug resistance
- Agents that prevent the spread of cancer
What is the main difference between cytotoxic and cytostatic anticancer drugs?
What is the main difference between cytotoxic and cytostatic anticancer drugs?
- Cytotoxic drugs exhibit strong anticancer effects, while cytostatic drugs show low sensitivity rates in drug sensitivity tests (correct)
- Cytostatic drugs inhibit tumor growth, while cytotoxic drugs mainly exhibit anticancer effects in clinical situations
- Cytostatic drugs easily induce multidrug resistance, while cytotoxic drugs show better survival benefits
- Cytotoxic drugs target tumorigenic molecules, while cytostatic drugs exhibit strong anticancer effects
Which of the following is an example of an anticancer agent?
Which of the following is an example of an anticancer agent?
- Bleomycin (correct)
- Paracetamol
- Aspirin
- Ibuprofen
Which type of anticancer drug shows better survival benefits for patients?
Which type of anticancer drug shows better survival benefits for patients?
What is the main drawback of cytotoxic anticancer drugs?
What is the main drawback of cytotoxic anticancer drugs?
What is the main enzyme responsible for the catabolism of 5-FU?
What is the main enzyme responsible for the catabolism of 5-FU?
What is the major human metabolite of 5-FU?
What is the major human metabolite of 5-FU?
Which metabolite of 6-Mercaptopurine requires bioactivation by Hypoxanthine-guanine phosphoribosyltransferase?
Which metabolite of 6-Mercaptopurine requires bioactivation by Hypoxanthine-guanine phosphoribosyltransferase?
What role does Fluorine play in 5-FU's mechanism of action?
What role does Fluorine play in 5-FU's mechanism of action?
Which process leads to inhibition of synthesis and function of DNA and RNA by 5-FU?
Which process leads to inhibition of synthesis and function of DNA and RNA by 5-FU?
What is involved in the alkylation of DNA?
What is involved in the alkylation of DNA?
What is the primary mechanism of action for cyclophosphamide?
What is the primary mechanism of action for cyclophosphamide?
Which of the following is a major metabolite of cyclophosphamide?
Which of the following is a major metabolite of cyclophosphamide?
Which of the following is responsible for bladder toxicity associated with cyclophosphamide?
Which of the following is responsible for bladder toxicity associated with cyclophosphamide?
What is the primary reason for co-administering mesna with cyclophosphamide?
What is the primary reason for co-administering mesna with cyclophosphamide?
Which of the following is true about ifosfamide compared to cyclophosphamide?
Which of the following is true about ifosfamide compared to cyclophosphamide?
What is the primary cause of neurotoxicity associated with ifosfamide?
What is the primary cause of neurotoxicity associated with ifosfamide?
What is the main reason gemcitabine is considered a potent radiosensitizer?
What is the main reason gemcitabine is considered a potent radiosensitizer?
Which characteristic of cladribine contributes to its efficacy in treating chronic lymphocytic leukemia and nonHodgkin’s lymphoma?
Which characteristic of cladribine contributes to its efficacy in treating chronic lymphocytic leukemia and nonHodgkin’s lymphoma?
How does leucovorin (folinic acid) enhance the antitumor activity of 5-fluorouracil?
How does leucovorin (folinic acid) enhance the antitumor activity of 5-fluorouracil?
Which interaction is associated with pretreatment with methotrexate?
Which interaction is associated with pretreatment with methotrexate?
What adverse effect is associated with the combination of fludarabine and pentostatin?
What adverse effect is associated with the combination of fludarabine and pentostatin?
Which property of gemcitabine prevents it from crossing the blood-brain barrier effectively?
Which property of gemcitabine prevents it from crossing the blood-brain barrier effectively?
What is the primary metabolite of Taxol (paclitaxel) and how is it formed?
What is the primary metabolite of Taxol (paclitaxel) and how is it formed?
Which enzyme is responsible for the para hydroxylation of Taxol's phenyl group?
Which enzyme is responsible for the para hydroxylation of Taxol's phenyl group?
Which patients are more likely to have a greater degree of para hydroxy metabolite of Taxol due to metabolism differences?
Which patients are more likely to have a greater degree of para hydroxy metabolite of Taxol due to metabolism differences?
What is the mechanism of action of epipodophyllotoxins, derivatives of podophyllotoxin?
What is the mechanism of action of epipodophyllotoxins, derivatives of podophyllotoxin?
What is the major route of metabolism for Irinotecan when used in colon cancer treatment?
What is the major route of metabolism for Irinotecan when used in colon cancer treatment?
Which antineoplastic drug leads to the formation of stereoisomeric hydroxyoxazolidinones and an oxazolidinedione as part of its metabolism?
Which antineoplastic drug leads to the formation of stereoisomeric hydroxyoxazolidinones and an oxazolidinedione as part of its metabolism?
