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What is the primary benefit of a combination of IV iron and erythropoiesis-stimulating agents (ESAs) for chronic kidney disease patients?
What is the primary benefit of a combination of IV iron and erythropoiesis-stimulating agents (ESAs) for chronic kidney disease patients?
- More rapid decline in renal function compared to standard care
- Higher doses of ESAs required
- Lower hemoglobin levels achieved
- Reduction in the required dose of ESAs (correct)
Why is high-dose IV iron therapy not recommended for chronic kidney disease patients?
Why is high-dose IV iron therapy not recommended for chronic kidney disease patients?
- It causes iron deficiency
- It leads to a rapid increase in hemoglobin levels
- Concerns over iron toxicity and oxidative stress (correct)
- It improves renal function
What limits the efficacy and tolerability of oral iron therapy in patients with chronic diseases?
What limits the efficacy and tolerability of oral iron therapy in patients with chronic diseases?
- Decreased inflammatory cytokines
- Decreased iron absorption
- Specific inflammatory condition at the site of inhibition of erythropoiesis (correct)
- Improved utilization of iron
Why is a combination of erythropoiesis-stimulating agents (ESAs) and IV iron therapy more appropriate in certain cases?
Why is a combination of erythropoiesis-stimulating agents (ESAs) and IV iron therapy more appropriate in certain cases?
How does erythropoiesis-stimulating agents (ESAs) affect iron requirements in the body?
How does erythropoiesis-stimulating agents (ESAs) affect iron requirements in the body?
Why is oral iron considered the frontline treatment for Iron Deficiency Anemia (IDA)?
Why is oral iron considered the frontline treatment for Iron Deficiency Anemia (IDA)?
What was the result of administering iron and ascorbic acid to normal volunteers in a study?
What was the result of administering iron and ascorbic acid to normal volunteers in a study?
In what cases is the heme oxygenase inhibitor SnMP particularly useful when used with iron?
In what cases is the heme oxygenase inhibitor SnMP particularly useful when used with iron?
What is the preferred form of iron therapy according to the 2008 NICE guidelines?
What is the preferred form of iron therapy according to the 2008 NICE guidelines?
Why may treatment with oral iron alone be ineffective and potentially detrimental in cases associated with chronic inflammatory states or infection?
Why may treatment with oral iron alone be ineffective and potentially detrimental in cases associated with chronic inflammatory states or infection?
What do recent large randomized controlled trials suggest about the most effective regimens for iron replacement therapy?
What do recent large randomized controlled trials suggest about the most effective regimens for iron replacement therapy?
What is the purpose of initially giving oral iron for a few weeks followed by parenteral iron in anemic patients?
What is the purpose of initially giving oral iron for a few weeks followed by parenteral iron in anemic patients?
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