Colorectal Drug Delivery Quiz

What is the main reason why conventional drug delivery systems for treating colon disorders are failing?

The colon lacks well-defined villi, reducing the absorption surface area.
The drugs don't reach the site of action in appropriate concentration. (correct)
The colon has a lower absorption capacity than the small intestine.
Ingested materials remain in the colon for a much longer time.

What is the advantage of sustained colonic release of drugs?

It can be useful in the treatment of nocturnal asthma.
It can be useful in the treatment of angina.
It can be useful in the treatment of arthritis.
All of the above (correct)

What is the main reason why local treatment of colonic pathologies is more effective with the delivery of drugs to the affected area?

The colon has a lower absorption capacity than the small intestine.
Ingested materials remain in the colon for a much longer time.
The drugs can directly target the affected area in the colon. (correct)
The colon lacks well-defined villi, reducing the absorption surface area.

Which of the following colonic pathologies can benefit from local drug delivery to the affected area?

All of the above (D) Signup and view all the answers

What is the main reason why the colon has a lower absorption capacity than the small intestine?

The colon mucosa lacks well-defined villi as found in the small intestine. (C) Signup and view all the answers

What is the main reason why ingested materials remain in the colon for a much longer time?

The colon has a lower absorption capacity than the small intestine. (D) Signup and view all the answers

How does the coupling of drug carrier nano-systems to ligands differ from direct coupling of drugs to targeting ligands?

Coupling to ligands allows for the import of thousands of drug molecules per receptor targeted ligand (C) Signup and view all the answers

What is the primary benefit of nanoparticle formulations that can provide sustained-release profiles up to 24 hours?

Improved patient compliance with drug regimens (A) Signup and view all the answers

What is the primary purpose of using drug delivery devices?

To provide sustained-release of the medication (C) Signup and view all the answers

What is one of the favorable absorption sites for subcutaneous implantation of drug delivery devices?

The body tissue (D) Signup and view all the answers

What is a key requirement for the materials used in drug delivery device implants?

The materials must be biocompatible (A) Signup and view all the answers

What is a potential advantage of subcutaneous implantation of drug delivery devices?

The ability to remove the device at any time (C) Signup and view all the answers

What is the texture of the skin that the text describes as being similar to a cat's tongue or sharkskin?

Rough (D) Signup and view all the answers

What is the purpose of the solid silicon needles or hollow metal needles described in the text?

To penetrate the horny layer without breaking and without stimulating nerves in the deeper tissues (D) Signup and view all the answers

What is the purpose of the liposomes described in the text?

To entrap and deliver drugs to and through the skin (B) Signup and view all the answers

What property of liposomes can be modified to enhance their circulation time in the bloodstream?

Attaching polyethylene glycol (PEG) units to the bilayer (D) Signup and view all the answers

What is the purpose of conjugating liposomes to antibodies or ligands?

To enhance target-specific drug therapy (B) Signup and view all the answers

Why can dissolved hydrophilic solutes not readily pass through the lipid membrane of a liposome?

The liposome encapsulates a region of aqueous solution inside the hydrophobic membrane (A) Signup and view all the answers

What is a key property that the enhancer should not cause upon removal of allergenic material?

Loss of body fluids (B) Signup and view all the answers

Which statement accurately reflects the importance of hydration in skin penetration?

Hydration increases the penetration rate by opening the compact layer of the horny layer. (B) Signup and view all the answers

What enhances skin bioavailability among the listed options?

Transdermal films (B) Signup and view all the answers

What effect does the formation of lipophilic ion pairs have on drug permeability?

Decreases permeability (A) Signup and view all the answers

Which property is essential for a chemical to be considered a good solvent for drugs?

Ability to dissolve drugs effectively (A) Signup and view all the answers

Why is it important for an enhancer to be cosmetically acceptable?

'Feel' of skin should be good (B) Signup and view all the answers

What is the purpose of the implantable biosensor drug delivery system?

To control the release of medication (B) Signup and view all the answers

Which component signals the battery in the implantable biosensor drug delivery system?

Sensor (A) Signup and view all the answers

What role does telemetry play in the implantable biosensor drug delivery system?

Enabling physician/patient regulation of drug release (A) Signup and view all the answers

What distinguishes microfluidics as formulating devices?

Precision in handling nano-liter and pico-liter volumes of liquid (D) Signup and view all the answers

How does the implantable biosensor drug delivery system respond when a sufficient amount of medication has been released?

The polymer valves close, covering the perforations (B) Signup and view all the answers

What does the battery do when the sensor detects a chemical change in the implantable biosensor drug delivery system?

Emits an electrical charge (B) Signup and view all the answers