Collagen Assembly and Modification Quiz
37 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which protein is considered the 'Master' ECM protein?

  • Collagen IV
  • Nidogen
  • Laminin (correct)
  • Fibrillar Collagen

    • What are the two primary types of extracellular matrix?

  • Fibrillar Collagen and Fibronectin (correct)
  • Basement Membranes and Tissue Specificity
  • Laminin and Collagen IV
  • Proteoglycans and Glycosaminoglycans

    • Which proteins self-assemble to form a sheet-like structure?

  • Collagen IV (correct)
  • Laminin
  • Fibrillar Collagen
  • Nidogen

    • Which type of ECM contains laminin, collagen IV, heparan sulfate proteoglycan, and nidogen?

    <p>Basement Membrane</p> Signup and view all the answers

    What is the role of nidogen and heparan sulfate proteoglycans in basement membrane assembly?

    <p>All of the above</p> Signup and view all the answers

    Which type of ECM frequently contains cells within it and is characterized by fibrillar collagens, proteoglycans, and glycosaminoglycans?

    <p>Connective Tissue</p> Signup and view all the answers

    What is the primary producer of connective tissue ECM proteins?

    <p>Fibroblasts</p> Signup and view all the answers

    Which cellular organelles assist in the modification and assembly of collagen chains?

    <p>Endoplasmic Reticulum and Golgi Apparatus</p> Signup and view all the answers

    What is the role of C-propeptides in collagen assembly?

    <p>Cue chain recognition and bring subunits together</p> Signup and view all the answers

    What happens to procollagen in the extracellular space?

    <p>Propeptides are removed by specific proteases</p> Signup and view all the answers

    What is the role of Proteoglycans and Glycosaminoglycans (GAGs) in connective tissues?

    <p>Provide connective tissues with viscoelasticity and turgor</p> Signup and view all the answers

    Which protein components are essential in every basal lamina?

    <p>Laminin and collagen IV</p> Signup and view all the answers

    Which type of ECM is required for multi-cellular life?

    <p>Basement membranes/basal lamina</p> Signup and view all the answers

    What are the major protein components of connective tissue?

    <p>Fibrillar collagens</p> Signup and view all the answers

    How do laminin and collagen IV interact in the basement membrane?

    <p>They form independent networks that are tethered together by nidogen and perlecan</p> Signup and view all the answers

    Which type of cytoskeletal element is composed of actin filaments?

    <p>Microfilaments</p> Signup and view all the answers

    Which protein is responsible for the assembly and disassembly of microfilaments?

    <p>Actin Binding Proteins</p> Signup and view all the answers

    Which cytoskeletal element is involved in cell motility?

    <p>Microfilaments</p> Signup and view all the answers

    Which structure is composed of microtubules in a 9+2 array and associated proteins required for structural integrity and movement?

    <p>Axoneme</p> Signup and view all the answers

    What is the function of dynein in the molecular basis of movement?

    <p>To move along adjacent B tubules towards the minus end</p> Signup and view all the answers

    Which drug binds to tubulin and inhibits microtubule assembly?

    <p>Colchicine</p> Signup and view all the answers

    Which cytoskeletal component is dynamic and can undergo continuous assembly and disassembly in the cell?

    <p>Microfilaments</p> Signup and view all the answers

    What is the main type of protein subunits that form microtubules?

    <p>Alpha and Beta tubulin</p> Signup and view all the answers

    Which cytoskeletal component is characterized by a diameter of 10 nm and stability?

    <p>Intermediate Filaments</p> Signup and view all the answers

    Which proteins regulate the structure and function of F-actin in all cell types?

    <p>Actin Binding Proteins</p> Signup and view all the answers

    Which gene mutation can cause blistering disorders in the skin?

    <p>K14</p> Signup and view all the answers

    What is the function of desmin in the cytoskeleton?

    <p>Maintains the structural integrity of the contractile apparatus</p> Signup and view all the answers

    Which antibody is used as a tumor cell marker for glial cell tumors?

    <p>GFAP</p> Signup and view all the answers

    What is the basic structural unit of microtubules?

    <p>Alpha-tubulin and beta-tubulin heterodimer</p> Signup and view all the answers

    Which protein is responsible for cross-linking microfilament bundles in surface projections such as microvilli?

    <p>Fimbrin</p> Signup and view all the answers

    What is the function of stress fibers in cell movement?

    <p>To generate tension</p> Signup and view all the answers

    Which class of myosin contains traditional or conventional myosins such as skeletal and heart muscle myosin?

    <p>Myosin II</p> Signup and view all the answers

    What is the function of Myosin Light Chain Kinase (MLCK) in the regulation of Myosin II?

    <p>To phosphorylate Myosin Heavy Chains (MHC)</p> Signup and view all the answers

    Which protein is responsible for the movement of proteins and organelles along microfilaments?

    <p>Myosin I</p> Signup and view all the answers

    What is the main function of intermediate filaments?

    <p>To provide mechanical support and structural integrity to the cell</p> Signup and view all the answers

    Which type of ECM is characterized by fibrillar collagens, proteoglycans, and glycosaminoglycans?

    <p>Connective tissue</p> Signup and view all the answers

    What is the role of desmosomes in specialized cell contacts?

    <p>To facilitate cell-cell adhesion</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser