Collagen Assembly and Modification Quiz
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Questions and Answers

Which protein is considered the 'Master' ECM protein?

  • Collagen IV
  • Nidogen
  • Laminin (correct)
  • Fibrillar Collagen

    • What are the two primary types of extracellular matrix?

  • Fibrillar Collagen and Fibronectin (correct)
  • Basement Membranes and Tissue Specificity
  • Laminin and Collagen IV
  • Proteoglycans and Glycosaminoglycans

    • Which proteins self-assemble to form a sheet-like structure?

  • Collagen IV (correct)
  • Laminin
  • Fibrillar Collagen
  • Nidogen

    • Which type of ECM contains laminin, collagen IV, heparan sulfate proteoglycan, and nidogen?

    <p>Basement Membrane (B)</p> Signup and view all the answers

    What is the role of nidogen and heparan sulfate proteoglycans in basement membrane assembly?

    <p>All of the above (D)</p> Signup and view all the answers

    Which type of ECM frequently contains cells within it and is characterized by fibrillar collagens, proteoglycans, and glycosaminoglycans?

    <p>Connective Tissue (A)</p> Signup and view all the answers

    What is the primary producer of connective tissue ECM proteins?

    <p>Fibroblasts (C)</p> Signup and view all the answers

    Which cellular organelles assist in the modification and assembly of collagen chains?

    <p>Endoplasmic Reticulum and Golgi Apparatus (A)</p> Signup and view all the answers

    What is the role of C-propeptides in collagen assembly?

    <p>Cue chain recognition and bring subunits together (B)</p> Signup and view all the answers

    What happens to procollagen in the extracellular space?

    <p>Propeptides are removed by specific proteases (C)</p> Signup and view all the answers

    What is the role of Proteoglycans and Glycosaminoglycans (GAGs) in connective tissues?

    <p>Provide connective tissues with viscoelasticity and turgor (B)</p> Signup and view all the answers

    Which protein components are essential in every basal lamina?

    <p>Laminin and collagen IV (C)</p> Signup and view all the answers

    Which type of ECM is required for multi-cellular life?

    <p>Basement membranes/basal lamina (B)</p> Signup and view all the answers

    What are the major protein components of connective tissue?

    <p>Fibrillar collagens (B)</p> Signup and view all the answers

    How do laminin and collagen IV interact in the basement membrane?

    <p>They form independent networks that are tethered together by nidogen and perlecan (B)</p> Signup and view all the answers

    Which type of cytoskeletal element is composed of actin filaments?

    <p>Microfilaments (B)</p> Signup and view all the answers

    Which protein is responsible for the assembly and disassembly of microfilaments?

    <p>Actin Binding Proteins (C)</p> Signup and view all the answers

    Which cytoskeletal element is involved in cell motility?

    <p>Microfilaments (B)</p> Signup and view all the answers

    Which structure is composed of microtubules in a 9+2 array and associated proteins required for structural integrity and movement?

    <p>Axoneme (A)</p> Signup and view all the answers

    What is the function of dynein in the molecular basis of movement?

    <p>To move along adjacent B tubules towards the minus end (D)</p> Signup and view all the answers

    Which drug binds to tubulin and inhibits microtubule assembly?

    <p>Colchicine (A)</p> Signup and view all the answers

    Which cytoskeletal component is dynamic and can undergo continuous assembly and disassembly in the cell?

    <p>Microfilaments (D)</p> Signup and view all the answers

    What is the main type of protein subunits that form microtubules?

    <p>Alpha and Beta tubulin (C)</p> Signup and view all the answers

    Which cytoskeletal component is characterized by a diameter of 10 nm and stability?

    <p>Intermediate Filaments (D)</p> Signup and view all the answers

    Which proteins regulate the structure and function of F-actin in all cell types?

    <p>Actin Binding Proteins (C)</p> Signup and view all the answers

    Which gene mutation can cause blistering disorders in the skin?

    <p>K14 (D)</p> Signup and view all the answers

    What is the function of desmin in the cytoskeleton?

    <p>Maintains the structural integrity of the contractile apparatus (B)</p> Signup and view all the answers

    Which antibody is used as a tumor cell marker for glial cell tumors?

    <p>GFAP (B)</p> Signup and view all the answers

    What is the basic structural unit of microtubules?

    <p>Alpha-tubulin and beta-tubulin heterodimer (C)</p> Signup and view all the answers

    Which protein is responsible for cross-linking microfilament bundles in surface projections such as microvilli?

    <p>Fimbrin (C)</p> Signup and view all the answers

    What is the function of stress fibers in cell movement?

    <p>To generate tension (C)</p> Signup and view all the answers

    Which class of myosin contains traditional or conventional myosins such as skeletal and heart muscle myosin?

    <p>Myosin II (D)</p> Signup and view all the answers

    What is the function of Myosin Light Chain Kinase (MLCK) in the regulation of Myosin II?

    <p>To phosphorylate Myosin Heavy Chains (MHC) (C)</p> Signup and view all the answers

    Which protein is responsible for the movement of proteins and organelles along microfilaments?

    <p>Myosin I (D)</p> Signup and view all the answers

    What is the main function of intermediate filaments?

    <p>To provide mechanical support and structural integrity to the cell (A)</p> Signup and view all the answers

    Which type of ECM is characterized by fibrillar collagens, proteoglycans, and glycosaminoglycans?

    <p>Connective tissue (C)</p> Signup and view all the answers

    What is the role of desmosomes in specialized cell contacts?

    <p>To facilitate cell-cell adhesion (D)</p> Signup and view all the answers

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