Collagen Assembly and Modification Quiz

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Which protein is considered the 'Master' ECM protein?

Laminin

What are the two primary types of extracellular matrix?

Fibrillar Collagen and Fibronectin

Which proteins self-assemble to form a sheet-like structure?

Collagen IV

Which type of ECM contains laminin, collagen IV, heparan sulfate proteoglycan, and nidogen?

<p>Basement Membrane</p> Signup and view all the answers

What is the role of nidogen and heparan sulfate proteoglycans in basement membrane assembly?

<p>All of the above</p> Signup and view all the answers

Which type of ECM frequently contains cells within it and is characterized by fibrillar collagens, proteoglycans, and glycosaminoglycans?

<p>Connective Tissue</p> Signup and view all the answers

What is the primary producer of connective tissue ECM proteins?

<p>Fibroblasts</p> Signup and view all the answers

Which cellular organelles assist in the modification and assembly of collagen chains?

<p>Endoplasmic Reticulum and Golgi Apparatus</p> Signup and view all the answers

What is the role of C-propeptides in collagen assembly?

<p>Cue chain recognition and bring subunits together</p> Signup and view all the answers

What happens to procollagen in the extracellular space?

<p>Propeptides are removed by specific proteases</p> Signup and view all the answers

What is the role of Proteoglycans and Glycosaminoglycans (GAGs) in connective tissues?

<p>Provide connective tissues with viscoelasticity and turgor</p> Signup and view all the answers

Which protein components are essential in every basal lamina?

<p>Laminin and collagen IV</p> Signup and view all the answers

Which type of ECM is required for multi-cellular life?

<p>Basement membranes/basal lamina</p> Signup and view all the answers

What are the major protein components of connective tissue?

<p>Fibrillar collagens</p> Signup and view all the answers

How do laminin and collagen IV interact in the basement membrane?

<p>They form independent networks that are tethered together by nidogen and perlecan</p> Signup and view all the answers

Which type of cytoskeletal element is composed of actin filaments?

<p>Microfilaments</p> Signup and view all the answers

Which protein is responsible for the assembly and disassembly of microfilaments?

<p>Actin Binding Proteins</p> Signup and view all the answers

Which cytoskeletal element is involved in cell motility?

<p>Microfilaments</p> Signup and view all the answers

Which structure is composed of microtubules in a 9+2 array and associated proteins required for structural integrity and movement?

<p>Axoneme</p> Signup and view all the answers

What is the function of dynein in the molecular basis of movement?

<p>To move along adjacent B tubules towards the minus end</p> Signup and view all the answers

Which drug binds to tubulin and inhibits microtubule assembly?

<p>Colchicine</p> Signup and view all the answers

Which cytoskeletal component is dynamic and can undergo continuous assembly and disassembly in the cell?

<p>Microfilaments</p> Signup and view all the answers

What is the main type of protein subunits that form microtubules?

<p>Alpha and Beta tubulin</p> Signup and view all the answers

Which cytoskeletal component is characterized by a diameter of 10 nm and stability?

<p>Intermediate Filaments</p> Signup and view all the answers

Which proteins regulate the structure and function of F-actin in all cell types?

<p>Actin Binding Proteins</p> Signup and view all the answers

Which gene mutation can cause blistering disorders in the skin?

<p>K14</p> Signup and view all the answers

What is the function of desmin in the cytoskeleton?

<p>Maintains the structural integrity of the contractile apparatus</p> Signup and view all the answers

Which antibody is used as a tumor cell marker for glial cell tumors?

<p>GFAP</p> Signup and view all the answers

What is the basic structural unit of microtubules?

<p>Alpha-tubulin and beta-tubulin heterodimer</p> Signup and view all the answers

Which protein is responsible for cross-linking microfilament bundles in surface projections such as microvilli?

<p>Fimbrin</p> Signup and view all the answers

What is the function of stress fibers in cell movement?

<p>To generate tension</p> Signup and view all the answers

Which class of myosin contains traditional or conventional myosins such as skeletal and heart muscle myosin?

<p>Myosin II</p> Signup and view all the answers

What is the function of Myosin Light Chain Kinase (MLCK) in the regulation of Myosin II?

<p>To phosphorylate Myosin Heavy Chains (MHC)</p> Signup and view all the answers

Which protein is responsible for the movement of proteins and organelles along microfilaments?

<p>Myosin I</p> Signup and view all the answers

What is the main function of intermediate filaments?

<p>To provide mechanical support and structural integrity to the cell</p> Signup and view all the answers

Which type of ECM is characterized by fibrillar collagens, proteoglycans, and glycosaminoglycans?

<p>Connective tissue</p> Signup and view all the answers

What is the role of desmosomes in specialized cell contacts?

<p>To facilitate cell-cell adhesion</p> Signup and view all the answers

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