Cognitive Impairment Morphology and Pathology
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Questions and Answers

Which type of neurofibrillary tangles are associated with Alzheimer's disease?

  • Pick bodies
  • Amyloid core plaques
  • NEUROFIBRILLARY TANGLES (correct)
  • TDP43 inclusions
  • Which region of the brain is typically spared in Alzheimer's disease at the beginning?

  • Hippocampus
  • Basal forebrain
  • Frontal lobe (correct)
  • Amygdala
  • Which disorder is characterized by the presence of Pick bodies?

  • Frontotemporal Lobar Degeneration (correct)
  • Amyotrophic Lateral Sclerosis
  • Huntington's disease
  • Alzheimer's disease
  • What is the hallmark feature of Frontotemporal dementias?

    <p>Memory disturbances preceding behavioral issues</p> Signup and view all the answers

    Which area is preferentially affected in Frontotemporal Lobar Degeneration?

    <p>Frontal lobes</p> Signup and view all the answers

    What distinguishes the onset of symptoms between Frontotemporal dementias and Alzheimer's disease?

    <p>Younger age in Frontotemporal dementias</p> Signup and view all the answers

    What is typically a late manifestation of Alzheimer's disease due to sparing of certain brain regions?

    <p>Behavioral changes</p> Signup and view all the answers

    Which of the following is the central component of neuritic plaques in Alzheimer's disease?

    <p>Amyloid-β (Aβ) protein</p> Signup and view all the answers

    What is the primary location of neurofibrillary tangles in Alzheimer's disease?

    <p>Neuronal cytoplasm</p> Signup and view all the answers

    Which brain regions are typically spared until late stages of Alzheimer's disease?

    <p>Primary motor and sensory cortices</p> Signup and view all the answers

    What is the term used to describe the compensatory ventricular enlargement seen in Alzheimer's disease?

    <p>Hydrocephalus ex vacuo</p> Signup and view all the answers

    Which brain regions are typically affected first in Frontotemporal Lobar Degeneration (FTLD)?

    <p>Frontal and temporal lobes</p> Signup and view all the answers

    Which of the following is NOT a characteristic feature of Alzheimer's disease neuropathology?

    <p>Pronounced atrophy in the occipital lobe</p> Signup and view all the answers

    What is the hallmark pathological feature of Frontotemporal Lobar Degeneration (FTLD)?

    <p>Pick bodies</p> Signup and view all the answers

    In familial Alzheimer's disease, when do the deposition of amyloid-β and the formation of neurofibrillary tangles typically occur relative to cognitive impairment?

    <p>Up to 15-20 years before cognitive impairment</p> Signup and view all the answers

    Which of the following statements about the relationship between neuropathological changes and cognitive dysfunction in Alzheimer's disease is correct?

    <p>The number of neurofibrillary tangles correlates better with the degree of dementia than neuritic plaques</p> Signup and view all the answers

    What is the term used to describe the dilated, tortuous processes of dystrophic neurites surrounding the amyloid core in neuritic plaques?

    <p>Dystrophic neurites</p> Signup and view all the answers

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