Cognitive Impairment Morphology and Pathology

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Which type of neurofibrillary tangles are associated with Alzheimer's disease?

Pick bodies

Amyloid core plaques

NEUROFIBRILLARY TANGLES (correct)

TDP43 inclusions

Which region of the brain is typically spared in Alzheimer's disease at the beginning?

Hippocampus

Basal forebrain

Frontal lobe (correct)

Amygdala

Which disorder is characterized by the presence of Pick bodies?

Frontotemporal Lobar Degeneration (correct)

Amyotrophic Lateral Sclerosis

Huntington's disease

Alzheimer's disease

What is the hallmark feature of Frontotemporal dementias?

Memory disturbances preceding behavioral issues Signup and view all the answers

Which area is preferentially affected in Frontotemporal Lobar Degeneration?

Frontal lobes Signup and view all the answers

What distinguishes the onset of symptoms between Frontotemporal dementias and Alzheimer's disease?

Younger age in Frontotemporal dementias Signup and view all the answers

What is typically a late manifestation of Alzheimer's disease due to sparing of certain brain regions?

Behavioral changes Signup and view all the answers

Which of the following is the central component of neuritic plaques in Alzheimer's disease?

Amyloid-β (Aβ) protein Signup and view all the answers

What is the primary location of neurofibrillary tangles in Alzheimer's disease?

Neuronal cytoplasm Signup and view all the answers

Which brain regions are typically spared until late stages of Alzheimer's disease?

Primary motor and sensory cortices Signup and view all the answers

What is the term used to describe the compensatory ventricular enlargement seen in Alzheimer's disease?

Hydrocephalus ex vacuo Signup and view all the answers

Which brain regions are typically affected first in Frontotemporal Lobar Degeneration (FTLD)?

Frontal and temporal lobes Signup and view all the answers

Which of the following is NOT a characteristic feature of Alzheimer's disease neuropathology?

Pronounced atrophy in the occipital lobe Signup and view all the answers

What is the hallmark pathological feature of Frontotemporal Lobar Degeneration (FTLD)?

Pick bodies Signup and view all the answers

In familial Alzheimer's disease, when do the deposition of amyloid-β and the formation of neurofibrillary tangles typically occur relative to cognitive impairment?

Up to 15-20 years before cognitive impairment Signup and view all the answers

Which of the following statements about the relationship between neuropathological changes and cognitive dysfunction in Alzheimer's disease is correct?

The number of neurofibrillary tangles correlates better with the degree of dementia than neuritic plaques Signup and view all the answers

What is the term used to describe the dilated, tortuous processes of dystrophic neurites surrounding the amyloid core in neuritic plaques?

Dystrophic neurites Signup and view all the answers

Cognitive Impairment Morphology and Pathology

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