Cobalamins and Vitamin B12 Quiz
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Questions and Answers

What role do cobalamins play in the synthesis of succinic acid and methionine?

  • Facilitate the transfer of monocarbon groups (correct)
  • Act as carriers for propionic acid
  • Inactivate enzymes for homocysteine synthesis
  • Prevent the regeneration of tetrahydrofolic acid

    • What technique is currently used to determine serum vitamin B12 concentration?

  • Chemiluminescence immunoassays (correct)
  • Manual systems
  • Microbiological assays
  • Radioisotopic assays

    • When can a deficiency in serum vitamin B12 be considered based on laboratory standards?

  • When the level is less than 200 pg/mL (correct)
  • When the level exceeds 1000 pg/mL
  • When the level is between 200-400 pg/mL
  • When the level is over 500 pg/mL

    • What is the consequence of a chronic deficiency of vitamin B12?

    <p>Late onset of megaloblastic anemia, such as after gastrectomy</p> Signup and view all the answers

    What is the role of Intrinsic Factor autoantibodies in vitamin B12 absorption?

    <p>Leads to deficiency in absorption of vitamin B12</p> Signup and view all the answers

    How does a deficiency in vitamin B12 affect DNA synthesis?

    <p>Disturbs cell cycle causing cell gigantism and megaloblastic-type erythropoiesis</p> Signup and view all the answers

    Which condition may arise if there is a deficiency in methionine synthesis due to lack of vitamin B12?

    <p>Neurological disorders</p> Signup and view all the answers

    What is the role of transcobalamin 2 in the transport of vitamin B12?

    <p>Synthesized by the hepatocyte and transports B12</p> Signup and view all the answers

    Which vitamin B12 carrier protein is primarily responsible for transporting B12 to reserve organs like the liver?

    <p>Transcobalamin 1</p> Signup and view all the answers

    What is a characteristic of the total reserves of vitamin B12 in the body?

    <p>Ranging from 2 to 4 mg</p> Signup and view all the answers

    In which situations would there be an increased need for vitamin B12 consumption according to the text?

    <p>Situations of accelerated erythropoiesis like haemolysis and haemorrhage</p> Signup and view all the answers

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