Cobalamins and Vitamin B12 Quiz

Test your knowledge on cobalamins, coenzymes essential for various metabolic reactions such as the synthesis of succinic acid and methionine. Learn about the role of vitamin B12 in determining serum concentration through microbiological and radioisotopic methods.

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@WinningLutetium

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Questions and Answers

What role do cobalamins play in the synthesis of succinic acid and methionine?

Facilitate the transfer of monocarbon groups

What technique is currently used to determine serum vitamin B12 concentration?

Chemiluminescence immunoassays

When can a deficiency in serum vitamin B12 be considered based on laboratory standards?

When the level is less than 200 pg/mL

What is the consequence of a chronic deficiency of vitamin B12?

Late onset of megaloblastic anemia, such as after gastrectomy Signup and view all the answers

What is the role of Intrinsic Factor autoantibodies in vitamin B12 absorption?

Leads to deficiency in absorption of vitamin B12 Signup and view all the answers

How does a deficiency in vitamin B12 affect DNA synthesis?

Disturbs cell cycle causing cell gigantism and megaloblastic-type erythropoiesis Signup and view all the answers

Which condition may arise if there is a deficiency in methionine synthesis due to lack of vitamin B12?

Neurological disorders Signup and view all the answers

What is the role of transcobalamin 2 in the transport of vitamin B12?

Synthesized by the hepatocyte and transports B12 Signup and view all the answers

Which vitamin B12 carrier protein is primarily responsible for transporting B12 to reserve organs like the liver?

Transcobalamin 1 Signup and view all the answers

What is a characteristic of the total reserves of vitamin B12 in the body?

Ranging from 2 to 4 mg Signup and view all the answers

In which situations would there be an increased need for vitamin B12 consumption according to the text?

Situations of accelerated erythropoiesis like haemolysis and haemorrhage Signup and view all the answers

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