18 Questions
TFPI:Xa binds to TF: FVIIa complex.
False
Thrombomodulin-thrombin complex triggers the protein S system.
False
Protein S lacks protease activity.
True
APC dissociates from EPCR and interacts with PC in a 2:1 stoichiometric complex.
False
TF pathway is shut off as soon as a small amount of FXa is generated.
False
Protein S forms two main types: Free PS and Protein C-bound PS.
True
Tissue Factor Pathway Inhibitor (TFPI) is the principal regulator of the protein C regulatory system.
False
Antithrombin does not require protein Z, phospholipid & Ca++ to inhibit FXIa.
True
Antithrombin (AT) is synthesized in the liver and activated by the presence of excess thrombin.
False
The protein C regulatory system ensures that coagulation is widespread throughout the body.
False
Protein Z is synthesized in the liver and is a proteolytic enzyme.
False
Thrombin-thrombomodulin complex revises the function of thrombin from an anticoagulant to a procoagulant.
False
Heparin cofactor II (HCII) targets thrombin and does not require heparin.
False
Tissue Factor Pathway Inhibitor (TFPI) induces a conformational change of Antithrombin (AT) to allow binding of activated coagulation factors.
False
TFPI binds to heparan sulfate and releases TFPI by 7x Domain.
False
The reaction activity of Antithrombin is independent of the length of the heparin chain it binds to.
False
Kunitz-type serine protease inhibitor is a component of the Tissue Factor Pathway Inhibitor (TFPI).
True
Protein C Inhibitor targets thrombin as one of the serine proteases it inhibits.
True
Explore the regulatory mechanisms of the protein C system in blood coagulation. Learn about inhibitors and co-factors that maintain a balance between thrombosis and abnormal bleeding, slow down procoagulant activation, suppress thrombin production, and prevent excessive clotting.
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