12 Questions
What is the nature of coagulation factors?
Protein in nature
What is unique about Factor XIII compared to other enzymes?
It is a transglutaminase
What is the function of serine proteases in coagulation?
To hydrolyze peptide bonds
Which of the following is NOT a procoagulant?
Anti-thrombin III
What is the purpose of γ-carboxyglutamic acid residues in serine proteases?
To bind calcium ions
What is the function of α2 macroglobulin?
To inhibit proteolytic enzymes
Which coagulation factor is not a zymogen?
Fibrinogen
What is the common feature of Factors II, IX, X, and XI?
They are all zymogens
What is the role of calcium in serine proteases?
It creates a binding site for substrate
What is the purpose of High Molecular Weight Kininogen in coagulation?
It acts as a cofactor
Which of the following is NOT a type of coagulation factor?
Hormone
What is the common feature of Anti-thrombin III, complement I inhibitor, and α1 anti-trypsin?
They are all inhibitors
Study Notes
Coagulation Factors
- Coagulation factors are proteins present in fresh plasma, differing in the number of amino acids.
- Except for fibrinogen, all coagulation factors are either enzyme precursors or co-factors.
- All enzymes except Factor XIII (transglutaminase) are serine proteases, capable of hydrolyzing peptide bonds.
Biochemical Group of Coagulation Factors
- Procoagulants are classified into two groups: zymogens and co-factors.
- Zymogens are inactive materials that can be converted into enzymes by acid or another enzyme, and include Factors II, VII, IX, X, XI, XII, and Prekallikrein.
- Co-factors include Factors V, VIII, Tissue Factor, and High Molecular Weight Kininogen.
Protease (Proteolytic Enzyme)
- Serine proteases are enzymes that contain residues of amino acids called gamma carboxyglutamic acid, which have 2 carboxyl groups attached to the gamma carbon of glutamic acid.
- The extra carboxyl group creates a binding site for calcium.
Inhibitors (Blockers)
- Inhibitors of coagulation include Anti-thrombin III, complement I inhibitor, α2 macroglobulin, and α1 anti-trypsin.
Test your knowledge of coagulation factors, their properties, and biochemical groups. Learn about the different types of coagulation factors, their composition, and functions. Understand the role of enzymes and co-factors in the coagulation process.
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