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Coagulation Factors and Biochemistry

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Questions and Answers

What is the nature of coagulation factors?

Protein in nature (correct)

Lipid in nature

Carbohydrate in nature

Nucleic acid in nature

What is unique about Factor XIII compared to other enzymes?

It is a serine protease

It is a cofactor

It is a transglutaminase (correct)

It is a zymogen

What is the function of serine proteases in coagulation?

To hydrolyze peptide bonds (correct)

To inhibit clotting

To synthesize clotting factors

To activate zymogens

Which of the following is NOT a procoagulant?

Anti-thrombin III Signup and view all the answers

What is the purpose of γ-carboxyglutamic acid residues in serine proteases?

To bind calcium ions Signup and view all the answers

What is the function of α2 macroglobulin?

To inhibit proteolytic enzymes Signup and view all the answers

Which coagulation factor is not a zymogen?

Fibrinogen Signup and view all the answers

What is the common feature of Factors II, IX, X, and XI?

They are all zymogens Signup and view all the answers

What is the role of calcium in serine proteases?

It creates a binding site for substrate Signup and view all the answers

What is the purpose of High Molecular Weight Kininogen in coagulation?

It acts as a cofactor Signup and view all the answers

Which of the following is NOT a type of coagulation factor?

Hormone Signup and view all the answers

What is the common feature of Anti-thrombin III, complement I inhibitor, and α1 anti-trypsin?

They are all inhibitors Signup and view all the answers

Study Notes

Coagulation Factors

Coagulation factors are proteins present in fresh plasma, differing in the number of amino acids.
Except for fibrinogen, all coagulation factors are either enzyme precursors or co-factors.
All enzymes except Factor XIII (transglutaminase) are serine proteases, capable of hydrolyzing peptide bonds.

Biochemical Group of Coagulation Factors

Procoagulants are classified into two groups: zymogens and co-factors.
Zymogens are inactive materials that can be converted into enzymes by acid or another enzyme, and include Factors II, VII, IX, X, XI, XII, and Prekallikrein.
Co-factors include Factors V, VIII, Tissue Factor, and High Molecular Weight Kininogen.

Protease (Proteolytic Enzyme)

Serine proteases are enzymes that contain residues of amino acids called gamma carboxyglutamic acid, which have 2 carboxyl groups attached to the gamma carbon of glutamic acid.
The extra carboxyl group creates a binding site for calcium.

Inhibitors (Blockers)

Inhibitors of coagulation include Anti-thrombin III, complement I inhibitor, α2 macroglobulin, and α1 anti-trypsin.

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Description

Test your knowledge of coagulation factors, their properties, and biochemical groups. Learn about the different types of coagulation factors, their composition, and functions. Understand the role of enzymes and co-factors in the coagulation process.