Coagulatio Sanguinis: Pathways

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Questions and Answers

Quae via coagulationis extrinsecae activator esse dicitur?

Fibrinogen

Faktor tissularis (correct)

Vitamina K

Thrombin

Quae complexio viae coagulationis extrinsecae formatur?

VIII complex

X complex

XI complex

VII complex (correct)

Quae substancia necessaria est ad reactionem coagulationis viae extrinsecae?

Calcium (correct)

Phospholipides

Fibrinogen

Vitamina K

Quae substancia inhibitio coagulationis viae extrinsecae effectum habet?

Sodium citrate Signup and view all the answers

Quae via coagulationis est parallela viae extrinsecae?

Via coagulationis intrinsecae Signup and view all the answers

Quae substancia producitur per reactionem viae coagulationis extrinsecae?

Fibrin Signup and view all the answers

Quae reactio est opposita reactioni coagulationis viae extrinsecae?

Fibrinolysis Signup and view all the answers

Quae substancia inhibitorium effectum habet in thrombin?

Heparin Signup and view all the answers

Quae substantia initiaverit viam extrinsicam coagulationis sanguinis?

Thromboplastinum (factor III) Signup and view all the answers

Quae via coagulationis sanguinis est via directa?

Via extrinsic Signup and view all the answers

Quae substantia necessaria est ut fieri possit coagulatio sanguinis?

Omnia supra Signup and view all the answers

Quae est functio thromboplastini in coagulatione sanguinis?

Initiare viam extrinsicam Signup and view all the answers

Quae est relatio inter thromboplastinum et factor III?

Factor III est thromboplastinum Signup and view all the answers

Quae est functio calcium in coagulatione sanguinis?

Est cofactor in omni step coagulationis Signup and view all the answers

Quid est hemostasis?

Cessatio sanguinis fluendi quando vas sanguineum est laesum Signup and view all the answers

Quid evenit quando endothelium intactum est?

Plateletae inhibentur ab aggregando et adhaerendo ad parietem vasorum Signup and view all the answers

Quid est functio CD39 enzymi?

Convertit ADP in AMP et Pi Signup and view all the answers

Quid est effectus von Willebrand's factori in plateletis?

Facit aggregandum plateletarum Signup and view all the answers

Quid secretum est ab plateletis activatis?

ADP et thromboxanum A Signup and view all the answers

Quid est effectus thromboxani A in plateletis?

Facit aggregandum et vasoconstrictionem plateletarum Signup and view all the answers

Quid est forma coaguli sanguinis?

Fibrinum proteinum web penetrat et circumdat plateletas plug Signup and view all the answers

Quid est effectus vasoconstrictionis in hemostasi?

Cessatio sanguinis fluendi Signup and view all the answers

Study Notes

Coagulatio Externa

Via coagulationis externae, factor VII activatur per thromboplastinum tissularum (factor III)
Pathway shortcut: thromboplastinum tissulare → factor VII → complexus V → thrombinum

Coagulatio Interna

Via coagulationis internae, factor XII activatur per superficies negativae, sicut collagenum vel vitrum
Cascade reaction: factor XII → factor XI → factor IX → factor X → thrombinum

Commune Via Coagulationis

Activated factor X → thrombinum
Thrombinum → fibrinogenum → fibrinum
Cofactores necessarii: calcium, phospholipida (ab platellets)

Hemostasis

Hemostasis: cessatio haemorrhagiae quando vas sanguineum laedatur
Processus hemostasis: vasoconstrictio, aggregatio platelletarum, formatio retei fibrinae

Protectio Endothelii Intacti

Endothelium intactum vasoactive substances (PGI2, NO) secretat, quae:
- Vasodilatant
- Inhibent aggregationem platelletarum
Endothelium intactum CD39 enzyma secretat, quae ADP in AMP et Pi convertit, aggregationem platelletarum inhibens

Damnum Endothelii

Endothelium laesum collagenum exposuit
Plateltae ad collagenum adherent, von Willebrand factor plateltae et collagenum coniungit
Plateltae reactionem release (ADP, serotonin, thromboxanum A2) habent, quae plateltae aggregationem amplificant