Coagulatio Sanguinis: Pathways
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Questions and Answers

Quae via coagulationis extrinsecae activator esse dicitur?

  • Fibrinogen
  • Faktor tissularis (correct)
  • Vitamina K
  • Thrombin

Quae complexio viae coagulationis extrinsecae formatur?

  • VIII complex
  • X complex
  • XI complex
  • VII complex (correct)

Quae substancia necessaria est ad reactionem coagulationis viae extrinsecae?

  • Calcium (correct)
  • Phospholipides
  • Fibrinogen
  • Vitamina K

Quae substancia inhibitio coagulationis viae extrinsecae effectum habet?

<p>Sodium citrate (B)</p> Signup and view all the answers

Quae via coagulationis est parallela viae extrinsecae?

<p>Via coagulationis intrinsecae (C)</p> Signup and view all the answers

Quae substancia producitur per reactionem viae coagulationis extrinsecae?

<p>Fibrin (B)</p> Signup and view all the answers

Quae reactio est opposita reactioni coagulationis viae extrinsecae?

<p>Fibrinolysis (B)</p> Signup and view all the answers

Quae substancia inhibitorium effectum habet in thrombin?

<p>Heparin (A)</p> Signup and view all the answers

Quae substantia initiaverit viam extrinsicam coagulationis sanguinis?

<p>Thromboplastinum (factor III) (D)</p> Signup and view all the answers

Quae via coagulationis sanguinis est via directa?

<p>Via extrinsic (A)</p> Signup and view all the answers

Quae substantia necessaria est ut fieri possit coagulatio sanguinis?

<p>Omnia supra (D)</p> Signup and view all the answers

Quae est functio thromboplastini in coagulatione sanguinis?

<p>Initiare viam extrinsicam (D)</p> Signup and view all the answers

Quae est relatio inter thromboplastinum et factor III?

<p>Factor III est thromboplastinum (A)</p> Signup and view all the answers

Quae est functio calcium in coagulatione sanguinis?

<p>Est cofactor in omni step coagulationis (A)</p> Signup and view all the answers

Quid est hemostasis?

<p>Cessatio sanguinis fluendi quando vas sanguineum est laesum (D)</p> Signup and view all the answers

Quid evenit quando endothelium intactum est?

<p>Plateletae inhibentur ab aggregando et adhaerendo ad parietem vasorum (B)</p> Signup and view all the answers

Quid est functio CD39 enzymi?

<p>Convertit ADP in AMP et Pi (A)</p> Signup and view all the answers

Quid est effectus von Willebrand's factori in plateletis?

<p>Facit aggregandum plateletarum (C)</p> Signup and view all the answers

Quid secretum est ab plateletis activatis?

<p>ADP et thromboxanum A (C)</p> Signup and view all the answers

Quid est effectus thromboxani A in plateletis?

<p>Facit aggregandum et vasoconstrictionem plateletarum (B)</p> Signup and view all the answers

Quid est forma coaguli sanguinis?

<p>Fibrinum proteinum web penetrat et circumdat plateletas plug (C)</p> Signup and view all the answers

Quid est effectus vasoconstrictionis in hemostasi?

<p>Cessatio sanguinis fluendi (B)</p> Signup and view all the answers

Study Notes

Coagulatio Externa

  • Via coagulationis externae, factor VII activatur per thromboplastinum tissularum (factor III)
  • Pathway shortcut: thromboplastinum tissulare → factor VII → complexus V → thrombinum

Coagulatio Interna

  • Via coagulationis internae, factor XII activatur per superficies negativae, sicut collagenum vel vitrum
  • Cascade reaction: factor XII → factor XI → factor IX → factor X → thrombinum

Commune Via Coagulationis

  • Activated factor X → thrombinum
  • Thrombinum → fibrinogenum → fibrinum
  • Cofactores necessarii: calcium, phospholipida (ab platellets)

Hemostasis

  • Hemostasis: cessatio haemorrhagiae quando vas sanguineum laedatur
  • Processus hemostasis: vasoconstrictio, aggregatio platelletarum, formatio retei fibrinae

Protectio Endothelii Intacti

  • Endothelium intactum vasoactive substances (PGI2, NO) secretat, quae:
    • Vasodilatant
    • Inhibent aggregationem platelletarum
  • Endothelium intactum CD39 enzyma secretat, quae ADP in AMP et Pi convertit, aggregationem platelletarum inhibens

Damnum Endothelii

  • Endothelium laesum collagenum exposuit
  • Plateltae ad collagenum adherent, von Willebrand factor plateltae et collagenum coniungit
  • Plateltae reactionem release (ADP, serotonin, thromboxanum A2) habent, quae plateltae aggregationem amplificant

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Description

Descriptio pathways coagulationis sanguinis. Extrinsic pathway et intrinsic pathway. Activatores et colligatio communis.

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