Coagulatio Sanguinis: Pathways
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Questions and Answers

Quae via coagulationis extrinsecae activator esse dicitur?

  • Fibrinogen
  • Faktor tissularis (correct)
  • Vitamina K
  • Thrombin
  • Quae complexio viae coagulationis extrinsecae formatur?

  • VIII complex
  • X complex
  • XI complex
  • VII complex (correct)
  • Quae substancia necessaria est ad reactionem coagulationis viae extrinsecae?

  • Calcium (correct)
  • Phospholipides
  • Fibrinogen
  • Vitamina K
  • Quae substancia inhibitio coagulationis viae extrinsecae effectum habet?

    <p>Sodium citrate</p> Signup and view all the answers

    Quae via coagulationis est parallela viae extrinsecae?

    <p>Via coagulationis intrinsecae</p> Signup and view all the answers

    Quae substancia producitur per reactionem viae coagulationis extrinsecae?

    <p>Fibrin</p> Signup and view all the answers

    Quae reactio est opposita reactioni coagulationis viae extrinsecae?

    <p>Fibrinolysis</p> Signup and view all the answers

    Quae substancia inhibitorium effectum habet in thrombin?

    <p>Heparin</p> Signup and view all the answers

    Quae substantia initiaverit viam extrinsicam coagulationis sanguinis?

    <p>Thromboplastinum (factor III)</p> Signup and view all the answers

    Quae via coagulationis sanguinis est via directa?

    <p>Via extrinsic</p> Signup and view all the answers

    Quae substantia necessaria est ut fieri possit coagulatio sanguinis?

    <p>Omnia supra</p> Signup and view all the answers

    Quae est functio thromboplastini in coagulatione sanguinis?

    <p>Initiare viam extrinsicam</p> Signup and view all the answers

    Quae est relatio inter thromboplastinum et factor III?

    <p>Factor III est thromboplastinum</p> Signup and view all the answers

    Quae est functio calcium in coagulatione sanguinis?

    <p>Est cofactor in omni step coagulationis</p> Signup and view all the answers

    Quid est hemostasis?

    <p>Cessatio sanguinis fluendi quando vas sanguineum est laesum</p> Signup and view all the answers

    Quid evenit quando endothelium intactum est?

    <p>Plateletae inhibentur ab aggregando et adhaerendo ad parietem vasorum</p> Signup and view all the answers

    Quid est functio CD39 enzymi?

    <p>Convertit ADP in AMP et Pi</p> Signup and view all the answers

    Quid est effectus von Willebrand's factori in plateletis?

    <p>Facit aggregandum plateletarum</p> Signup and view all the answers

    Quid secretum est ab plateletis activatis?

    <p>ADP et thromboxanum A</p> Signup and view all the answers

    Quid est effectus thromboxani A in plateletis?

    <p>Facit aggregandum et vasoconstrictionem plateletarum</p> Signup and view all the answers

    Quid est forma coaguli sanguinis?

    <p>Fibrinum proteinum web penetrat et circumdat plateletas plug</p> Signup and view all the answers

    Quid est effectus vasoconstrictionis in hemostasi?

    <p>Cessatio sanguinis fluendi</p> Signup and view all the answers

    Study Notes

    Coagulatio Externa

    • Via coagulationis externae, factor VII activatur per thromboplastinum tissularum (factor III)
    • Pathway shortcut: thromboplastinum tissulare → factor VII → complexus V → thrombinum

    Coagulatio Interna

    • Via coagulationis internae, factor XII activatur per superficies negativae, sicut collagenum vel vitrum
    • Cascade reaction: factor XII → factor XI → factor IX → factor X → thrombinum

    Commune Via Coagulationis

    • Activated factor X → thrombinum
    • Thrombinum → fibrinogenum → fibrinum
    • Cofactores necessarii: calcium, phospholipida (ab platellets)

    Hemostasis

    • Hemostasis: cessatio haemorrhagiae quando vas sanguineum laedatur
    • Processus hemostasis: vasoconstrictio, aggregatio platelletarum, formatio retei fibrinae

    Protectio Endothelii Intacti

    • Endothelium intactum vasoactive substances (PGI2, NO) secretat, quae:
      • Vasodilatant
      • Inhibent aggregationem platelletarum
    • Endothelium intactum CD39 enzyma secretat, quae ADP in AMP et Pi convertit, aggregationem platelletarum inhibens

    Damnum Endothelii

    • Endothelium laesum collagenum exposuit
    • Plateltae ad collagenum adherent, von Willebrand factor plateltae et collagenum coniungit
    • Plateltae reactionem release (ADP, serotonin, thromboxanum A2) habent, quae plateltae aggregationem amplificant

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    Description

    Descriptio pathways coagulationis sanguinis. Extrinsic pathway et intrinsic pathway. Activatores et colligatio communis.

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