Podcast
Questions and Answers
What are the most widely prescribed drugs in current use to treat neurologic and psychiatric conditions, pain, fever, and nausea?
What are the most widely prescribed drugs in current use to treat neurologic and psychiatric conditions, pain, fever, and nausea?
CNS drugs
What is the major action of the drugs currently approved for use in Alzheimer’s disease?
What is the major action of the drugs currently approved for use in Alzheimer’s disease?
Inhibition of ACh metabolism
What is the second class of drug targets, especially for antidepressant agents?
What is the second class of drug targets, especially for antidepressant agents?
Neurotransmitter reuptake transporters
Which receptor subtype is excitatory and coupled to the second messenger system?
Which receptor subtype is excitatory and coupled to the second messenger system?
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What type of receptor subtype is 5-HT3 and how is it different from other subtypes?
What type of receptor subtype is 5-HT3 and how is it different from other subtypes?
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Which psychiatric drug is an antagonist of 5-HT3 and what is its clinical use?
Which psychiatric drug is an antagonist of 5-HT3 and what is its clinical use?
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What is the first marketed non-competitive antagonist of AMPA receptors?
What is the first marketed non-competitive antagonist of AMPA receptors?
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Which neurotransmitter is the primary mediator of fast IPSP in neurons in the brain?
Which neurotransmitter is the primary mediator of fast IPSP in neurons in the brain?
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What is the marine toxin that activates Kainate receptors and causes excitatory toxicity?
What is the marine toxin that activates Kainate receptors and causes excitatory toxicity?
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Which drug is a GABA agonist and is used as a sedative hypnotic and anticonvulsant?
Which drug is a GABA agonist and is used as a sedative hypnotic and anticonvulsant?
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Study Notes
Neurological and Psychiatric Medications
- Most widely prescribed drugs for neurologic and psychiatric conditions, pain, fever, and nausea are not specified, but the following information provides context on various medications.
Alzheimer's Disease Treatment
- The major action of drugs approved for Alzheimer's disease is to enhance the activity of the neurotransmitter acetylcholine by inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine.
Antidepressant Agents
- The second class of drug targets, especially for antidepressant agents, is the monoamine neurotransmitters (serotonin, norepinephrine, dopamine).
- This class of drugs targets the reuptake of these neurotransmitters, increasing their concentrations in the synaptic cleft.
Serotonin Receptor Subtypes
- The 5-HT3 receptor subtype is a ligand-gated ion channel and is excitatory, coupled to the second messenger system.
- 5-HT3 is different from other serotonin receptor subtypes because it is a ligand-gated ion channel, whereas others are G-protein coupled receptors.
Antipsychotic and Antiemetic Medications
- Ondansetron is an antagonist of 5-HT3 receptors and is used clinically as an antiemetic to treat nausea and vomiting, particularly in chemotherapy and surgery.
AMPA Receptors
- The first marketed non-competitive antagonist of AMPA receptors is Perampanel.
Neurotransmitters and IPSP
- GABA (gamma-aminobutyric acid) is the primary mediator of fast IPSP (inhibitory postsynaptic potential) in neurons in the brain.
Marine Toxins and Kainate Receptors
- The marine toxin domoic acid activates Kainate receptors, causing excitatory toxicity.
Sedative Hypnotics and Anticonvulsants
- Phenobarbital is a GABA agonist, used as a sedative hypnotic and anticonvulsant.
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Description
Test your understanding of drugs acting in the central nervous system with this quiz based on the content from Dr. Hiwa K. Saaed's lecture series. The quiz covers key concepts from the 4th year course and is based on 'Katzung & Trevor’s Pharmacology Examination and Board Review, 12th Edition (2019)' by Anthony J. Trevor.
