CNS Depressants
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Questions and Answers

What is the gait pattern observed in the case of CPZ?

  • No gait
  • Normal gait
  • Staggered gait
  • Creeping gait (correct)

    • What is the onset time for Thiopental?

  • 5-10 min
  • 15-25 min
  • 30-40 min
  • 3-7 min (correct)

    • What is the classification of Chloral hydrate?

  • Benzodiazepine
  • Antipsychotic (major tranquilizer)
  • Ultra short acting barbiturate
  • Non barbiturate Sedative hypnotic (correct)

    • What is the effect of CPZ on grip strength?

    <p>Loss of grip strength</p> Signup and view all the answers

    What is the common characteristic among the three drugs?

    <p>All are CNS depressants</p> Signup and view all the answers

    What is the type of anesthesia induced by Thiopental?

    <p>General anesthesia</p> Signup and view all the answers

    What is the characteristic of Chloral hydrate-induced hypnosis?

    <p>With open eyes</p> Signup and view all the answers

    What is the category of CPZ?

    <p>Antipsychotic (major tranquilizer)</p> Signup and view all the answers

    What is the duration of onset for Chloral hydrate?

    <p>15-25 min</p> Signup and view all the answers

    What is the effect of CPZ on the CNS?

    <p>Depression</p> Signup and view all the answers

    Study Notes

    Central Nervous System (CNS) Depressants

    • CNS depressants are drugs that slow down brain activity by affecting the neurotransmitter gamma-aminobutyric acid (GABA).
    • These drugs are used to treat disorders such as insomnia, anxiety, sleep disorders, and seizures.

    Types of CNS Depressants

    • Sedatives: produce a state of drowsiness in smaller doses.
    • Hypnotics: induce sleep, and can be classified into barbiturate and non-barbiturate hypnotics.
    • Tranquilizers: relieve mental anxiety and stress without affecting consciousness.

    Hypnotics

    • Barbiturate hypnotics can be classified into long, intermediate, short, and ultra-short acting barbiturates.
    • Examples of hypnotics: Thiopental (ultra-short acting barbiturate), Chloral hydrate (non-barbiturate hypnotic).

    Tranquilizers

    • Chlorpromazine is a prototypical phenothiazine antipsychotic drug that blocks post-synaptic D2 dopamine receptors in the mesolimbic area.
    • It relieves mental anxiety and stress without affecting consciousness.

    Scheme of Identification

    • General parameters: species (frog or mouse), sex (male or female), age (mature), weight (> 10 grams), dose calculation, and route of administration (S.C or I.P).
    • Specific parameters: vitality, activity, heart rate, respiratory rate, eye (ball and pupil), reflexes, gait, secretions, excretions, and CNS manifestations.

    Thiopental, Chloral Hydrate, and CPZ

    • Thiopental: ultra-short acting barbiturate, induces hypnosis with closed eyes, and has a rapid onset of 3-7 minutes.
    • Chloral hydrate: non-barbiturate hypnotic, induces hypnosis with open eyes, and has a slower onset of 15-25 minutes.
    • CPZ: antipsychotic drug, induces creeping gait, catalepsy, and loss of grip strength, and has an onset of 5-10 minutes.

    Conclusion

    • Thiopental, Chloral hydrate, and CPZ are all CNS depressants, but belong to different drug subgroups: ultra-short acting barbiturate, non-barbiturate hypnotic, and antipsychotic, respectively.

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    Description

    Learn about Central Nervous System (CNS) depressants, their functions, and types. This quiz covers the uses of CNS depressants in treating insomnia, anxiety, sleep disorders, and seizures.

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