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Questions and Answers
Quale es un passo initial in le pathway intrinsic de coagulation?
Quale es un passo initial in le pathway intrinsic de coagulation?
Quale factor es essential in le pathway extrinseco?
Quale factor es essential in le pathway extrinseco?
Quale affirmatio super le factor 9 es ver?
Quale affirmatio super le factor 9 es ver?
Quale cofactor es necessario pro le production de prothrombin?
Quale cofactor es necessario pro le production de prothrombin?
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Quale es le rol del thrombin (IIa) in le cascade de coagulation?
Quale es le rol del thrombin (IIa) in le cascade de coagulation?
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Study Notes
Clotting Cascade
- The intrinsic pathway is initiated by contact activation, exposed collagen triggers the activation of factor 12.
- Factor 12 activates factor 11, which activates factor 9.
- Factor 9, with factor 8 and phospholipid cofactor initiate a cascade leading to activation of factor X.
- Factor 10 activation leads to prothrombin conversion to thrombin.
- The common pathway leads to thrombin, which converts fibrinogen into fibrin.
- The extrinsic pathway is initiated by damage to subendothelial cells and tissue, releasing tissue factor; activating factor VII, which activates factor X.
- The intrinsic and extrinsic pathways converge on factor X.
- Activated factor X, along with factor V and phospholipid cofactor, activate prothrombin to thrombin.
- Thrombin converts fibrinogen to fibrin, forming a clot.
- Thrombin and factor 13 crosslink fibrin fibers.
- Platelets contribute to the clotting cascade by releasing factors that promote clot formation at the injured site, and aggregating at the injury site.
- Vitamin K is required by the liver to synthesize some clotting factors.
- Negative feedback loops regulate the clotting cascade.
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Description
This quiz covers the clotting cascade, detailing both the intrinsic and extrinsic pathways. Learn how various factors interact to form a fibrin clot, highlighting the roles of thrombin and platelets in hemostasis. Test your knowledge on the key processes involved in blood coagulation.
