Pathology: Skeletal Muscle L2

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Questions and Answers

What are the four clostridial diseases affecting skeletal muscle?

Blackleg/pseudoblackleg, tetanus, botulism and malignant edema

What is the primary cause of black leg in cattle?

  • Clostridium botulinum
  • Clostridium chauvoei (correct)
  • Clostridium perfringens
  • Clostridium difficile

Which gross lesions are associated with black leg?

  • Pale, soft muscles
  • Thickened muscle fibers with white streaks
  • Muscles that are dark red to black, swollen, soft, and friable (correct)
  • Greenish discoloration and pus accumulation

What is a unique feature of black leg upon palpation?

<p>Palpable crepitus (bubble wrap popping sound) (B)</p> Signup and view all the answers

How does Clostridium chauvoei cause black leg?

<p>Ingestion of spores → dissemination via blood → latency → hypoxia → bacterial proliferation → exotoxin release → myonecrosis (B)</p> Signup and view all the answers

What are some common factors associated with black leg outbreaks?

<p>Soil disturbance, trauma, handling procedures (A), Parturition (B)</p> Signup and view all the answers

Which type of myositis is caused by Clostridium chauvoei or Clostridium septicum?

<p>Necrotic/hemorrhagic myositis (A)</p> Signup and view all the answers

Match the types of myositis to its associated cause

<p>Suppurative = Pyogenic bacteria Lymphocytic = Immune mediated Eosinophilic = Active protozoan/parasitic infections, immune mediated Granulomatous = Chronic inflammation (e.g. wooden tongue)</p> Signup and view all the answers

What type of inflammation is characteristic of Wooden Tongue?

<p>Pyogranulomatous to granulomatous and fibrosing myositis/glossitis (B)</p> Signup and view all the answers

How does Actinobacillus lignieresii infect the tongue?

<p>Via a penetrating or oral wound (A)</p> Signup and view all the answers

What histological feature is characteristic of Wooden Tongue?

<p>Spendore-Hoeppli-like material (B)</p> Signup and view all the answers

The red material observed in histology of Wooden Tongue is believed to be:

<p>Antibody-antigen complexes forming a brush border appearance (C)</p> Signup and view all the answers

Masticatory myositis is an example of what type of disease?

<p>Immune-mediated humoral autoimmune response (D)</p> Signup and view all the answers

Which muscles are primarily affected in masticatory myositis?

<p>Temporalis and masseter muscles</p> Signup and view all the answers

What is the underlying immune mechanism of masticatory myositis?

<p>Autoimmune response against type 2M fibers (A)</p> Signup and view all the answers

What is a common morphological diagnosis (MDx) for masticatory myositis?

<p>Chronic eosinophilic myositis with muscle atrophy (A)</p> Signup and view all the answers

What is a key clinical sign of extraocular polymyositis?

<p>Exophthalmus (eyeball protrusion) (A)</p> Signup and view all the answers

What causes exophthalmus in extraocular polymyositis?

<p>Increased muscle size due to inflammation pushing the eye forward (A)</p> Signup and view all the answers

Which breed is predisposed to extraocular polymyositis?

<p>Golden Retrievers (A)</p> Signup and view all the answers

What is polymyositis?

<p>An immune-mediated inflammatory response affecting skeletal muscle (A)</p> Signup and view all the answers

Which generalized immune-mediated disease can be associated with polymyositis?

<p>Systemic lupus erythematosus (B)</p> Signup and view all the answers

In dogs, polymyositis may occur in association with what type of tumor?

<p>Thymoma (C)</p> Signup and view all the answers

What is the predominant histological feature of polymyositis?

<p>Lymphocytic myositis (B)</p> Signup and view all the answers

What causes purpura hemorrhagica in horses?

<p>Circulating immune complexes following infection with Streptococcus equi (B)</p> Signup and view all the answers

Which bacterial infection is primarily associated with purpura hemorrhagica?

<p>Streptococcus equi (B)</p> Signup and view all the answers

What is the primary pathological consequence of purpura hemorrhagica?

<p>Multifocal vasculitis, hemorrhage, and infarction of muscle fibers (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic feature of purpura hemorrhagica?

<p>Presence of gas bubbles in muscle tissue (B)</p> Signup and view all the answers

Clostridial myositis in horses is most commonly associated with what event?

<p>Injections into muscle (C)</p> Signup and view all the answers

Which bacterial species is most commonly responsible for clostridial myositis following an injection?

<p>Clostridium septicum (B)</p> Signup and view all the answers

What are the primary pathological findings in clostridial myositis?

<p>Fibrosis and calcification (B)</p> Signup and view all the answers

What is a possible fatal consequence of clostridial myositis?

<p>Toxemia and septicemia (B)</p> Signup and view all the answers

What is the morphological diagnosis (MDx) for clostridial myositis?

<p>Focally extensive eosinophilic and necrotizing chronic myositis +/- fibrosis (B)</p> Signup and view all the answers

What is another cause of green appearance to muscle?

<p>Putrefaction</p> Signup and view all the answers

What is a key histological feature of Sarcocystis infection in muscle?

<p>Myositis with cyst-like structures and possible eosinophilia (B)</p> Signup and view all the answers

Sarcocystis cysts can sometimes be seen grossly in muscle

<p>True (A)</p> Signup and view all the answers

What is the morphological diagnosis (MDx) for Cysticercus (Taenia) infection in skeletal muscle?

<p>Skeletal muscle parasitic cysts with possible eosinophilic/granulomatous myositis (D)</p> Signup and view all the answers

What is the intermediate host for Taenia species that develop into Cysticercus in skeletal muscle?

<p>Herbivores (e.g., pigs, cattle) (C)</p> Signup and view all the answers

How do humans acquire Trichinella infection?

<p>Ingestion of undercooked meat (C)</p> Signup and view all the answers

What is a major public health concern associated with Trichinella infection?

<p>It is highly zoonotic and can infect humans (C)</p> Signup and view all the answers

What happens when Trichinella larvae die in muscle tissue?

<p>They induce an inflammatory response (B)</p> Signup and view all the answers

To what temperature should meat be cooked to prevent Trichinella infection?

<p>170°F (D)</p> Signup and view all the answers

What is the primary cause of muscle damage in Downer Cow Syndrome?

<p>Increased intramuscular pressure leading to ischemia and infarction (C)</p> Signup and view all the answers

Which gross lesion is characteristic of Downer Cow Syndrome?

<p>Discrete pale muscle bordered by red zones (B)</p> Signup and view all the answers

Which of the following can cause a lesion similar to Downer Cow Syndrome?

<p>Post-anesthesia recumbency in large animals (C)</p> Signup and view all the answers

What is the primary mechanism leading to deep pectoral myopathy?

<p>Muscle swelling confined by fascia, leading to ischemia and infarction (B)</p> Signup and view all the answers

Which of the following factors predisposes animals to deep pectoral myopathy?

<p>Rapid muscle growth (A)</p> Signup and view all the answers

Fill in the sequence of events for the pathogenesis of deep pectoral myopathy: Rapid muscle growth → __________ → muscle swelling →__________ → ischemia → _____________

<p>Rapid muscle growth → increased circulation → muscle swelling → blood flow obstruction → ischemia → infarction</p> Signup and view all the answers

What is another name for Myofibrillar Hypoplasia?

<p>Splay Leg (B)</p> Signup and view all the answers

What is the primary clinical sign of Myofibrillar Hypoplasia in neonates?

<p>Inability to stand with limbs abducted and a flattened chest (A)</p> Signup and view all the answers

What is the morphological diagnosis (MDx) for Swimmer’s Syndrome?

<p>Myofibrillar hypoplasia (A)</p> Signup and view all the answers

What is the expected outcome for most neonates with Swimmer’s Syndrome?

<p>Full recovery as myofilaments develop normally over time (B)</p> Signup and view all the answers

What is the primary cause of Double Muscle condition?

<p>Inactivation of the MSTN gene on chromosome 37 in dogs (B)</p> Signup and view all the answers

What is the function of myostatin protein in muscle development?

<p>It signals myocytes to stop dividing (B)</p> Signup and view all the answers

What happens when the MSTN gene is inactivated?

<p>Myocytes continue to divide, leading to excessive muscle fiber formation (A)</p> Signup and view all the answers

Which of the following is a potential issue in animals that are homozygous for an inactive myostatin gene?

<p>Reproductive issues (C)</p> Signup and view all the answers

What is the morphological diagnosis (MDx) for Double Muscle condition?

<p>Myocyte hyperplasia and hypertrophy due to a developmental anomaly (A)</p> Signup and view all the answers

What are common causes of myocyte hypertrophy?

<p>Exercise conditioning and compensatory mechanisms (B)</p> Signup and view all the answers

What is required for satellite cells (resting myoblasts) to divide?

<p>Presence of a basal lamina (A)</p> Signup and view all the answers

Flashcards

Four clostridial diseases affecting musculature

Blackleg/pseudoblackleg, tetanus, botulism, and malignant edema

Primary cause of blackleg in cattle

Clostridium chauvoei

Gross lesions associated with blackleg

Muscles that are dark red to black, swollen, soft, and friable

Unique feature of blackleg upon palpation

Palpable crepitus (bubble wrap popping sound)

Signup and view all the flashcards

How Clostridium chauvoei causes blackleg

Ingestion of spores → dissemination via blood → latency → hypoxia → bacterial proliferation → exotoxin release → myonecrosis

Signup and view all the flashcards

Inflammation type in Wooden Tongue

Myositis with pyogranulomatous to granulomatous inflammation

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How does Actinobacillus lignieresii infect?

Via a penetrating or oral wound

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Histological feature of Wooden Tongue

Spendore-Hoeppli-like material

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Composition of red material in Wooden Tongue histology

Antibody-antigen complexes forming a brush border appearance

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Masticatory myositis disease type

Immune-mediated humoral autoimmune response

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Muscles primarily affected in masticatory myositis

Temporalis and masseter muscles

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Immune mechanism of masticatory myositis

Autoimmune response against type 2M fibers

Signup and view all the flashcards

Morphological diagnosis for masticatory myositis

Chronic eosinophilic myositis with muscle atrophy

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Key clinical sign of extraocular polymyositis

Exophthalmus (eyeball protrusion)

Signup and view all the flashcards

Cause of exophthalmus in extraocular polymyositis

Increased muscle size due to inflammation pushing the eye forward

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Breed predisposed to extraocular polymyositis

Golden Retrievers

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Polymyositis

An immune-mediated inflammatory response affecting skeletal muscle

Signup and view all the flashcards

Generalized immune-mediated disease with polymyositis

Systemic lupus erythematosus

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Tumor associated with polymyositis in dogs

Thymoma

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Histological feature of polymyositis

Lymphocytic myositis

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Cause of purpura hemorrhagica in horses

Circulating immune complexes following infxn w/ Streptococcus equi

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Bacterial infection associated with purpura hemorrhagica

Streptococcus equi

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Pathological consequence of purpura hemorrhagica

Multifocal vasculitis, hemorrhage, and infarction of muscle fibers

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Event commonly linked to clostridial myositis in horses

Injections into muscle

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Bacterial species for clostridial myositis post-injection

Clostridium septicum

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Primary pathological findings in clostridial myositis

Fibrosis and calcification

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Fatal consequence of clostridial myositis

Toxemia and septicemia

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MDx for clostridial myositis

Focally extensive eosinophilic and necrotizing chronic myositis +/- fibrosis

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