Clonal Hematopoiesis and Stem Cell Mobilization Quiz

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Which factor limits autologous hematopoietic cell transplantation?

Inadequate mobilization of peripheral blood progenitor cells (PBPCs)

What did the study investigate?

The impact of clonal hematopoiesis (CH) on mobilization failure of PBPC for auto-HCT

Which mutations correspond with poor stem cell mobilization?

Mutations in PPM1D and TP53

What were the inclusion criteria for the mobilizations in this study?

All non-AML patients aged 18 years or older with the first mobilization procedure with G-CSF with or without preceding chemotherapy between January 1, 2007, and December 31, 2018. Signup and view all the answers

How many patients failed the mobilization procedure due to central line problems?

6 patients. Signup and view all the answers

What statistical test was used to compare parametric variables?

Student's t test. Signup and view all the answers

What is the definition of OS and time to t-MN in this study?

OS is the time from the first apheresis day until death from any cause or diagnosis of t-MN. Time to t-MN is the time from the first apheresis day until diagnosis of t-MN. Signup and view all the answers