Podcast
Questions and Answers
What is the mechanism of action of amodiaquine?
What is the mechanism of action of amodiaquine?
- Interference with the parasite's food vacuole transport system
- Inhibition of haemozoin formation (correct)
- Inhibition of DNA replication in the parasite
- Disruption of sporozoite development
What differentiates amodiaquine from other 4-aminoquinolines?
What differentiates amodiaquine from other 4-aminoquinolines?
- Inhibition of intrahepatic forms of Plasmodium
- Lack of schizontocidal activity
- Increased toxicity but lower blood concentration
- Gametocytocidal effect on P.vivax and P.falciparum gametocytes (correct)
How does mefloquine exert its anti-malarial effect?
How does mefloquine exert its anti-malarial effect?
- Disruption of haemoglobin digestion in the parasite
- Inhibition of DNA replication in the parasite
- Inhibition of the parasite's RNA function
- Interference with host-parasite metabolite transport (correct)
What is the role of haemozoin in the malaria parasite?
What is the role of haemozoin in the malaria parasite?
How does amodiaquine contribute to parasite death?
How does amodiaquine contribute to parasite death?
What makes amodiaquine particularly advantageous in treating malaria?
What makes amodiaquine particularly advantageous in treating malaria?
How do sulphonamides act as antimalarials?
How do sulphonamides act as antimalarials?
What is the mechanism of action of pyrimethamine?
What is the mechanism of action of pyrimethamine?
Which component of Fansidar acts as a folic acid inhibitor?
Which component of Fansidar acts as a folic acid inhibitor?
What enzyme do sulphonamides competitively inhibit?
What enzyme do sulphonamides competitively inhibit?
How do sulphonamides contribute to the death of parasites?
How do sulphonamides contribute to the death of parasites?
Which other antimalarial agent is known to contain N' (5,6-dimethoxy-4-pyrimidinyl sulfanilamide) and 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine?
Which other antimalarial agent is known to contain N' (5,6-dimethoxy-4-pyrimidinyl sulfanilamide) and 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine?
What is the role of DHFR inhibitors in antimalarial activity?
What is the role of DHFR inhibitors in antimalarial activity?
Which substitution on the quinoline nucleus tends to decrease both antimalarial activity and toxicity?
Which substitution on the quinoline nucleus tends to decrease both antimalarial activity and toxicity?
Which Biguanide has longer activity but becomes more toxic with a second chlorine at the meta position?
Which Biguanide has longer activity but becomes more toxic with a second chlorine at the meta position?
What type of substituent in the 5-position and the 6-position is required for the highest antimalarial activity in 2,4-diamino-pyrimidines?
What type of substituent in the 5-position and the 6-position is required for the highest antimalarial activity in 2,4-diamino-pyrimidines?
Which compound started as an antibacterial agent but was later found to be active as an antimalarial?
Which compound started as an antibacterial agent but was later found to be active as an antimalarial?
Where is the use of Artemisinin derivatives restricted?
Where is the use of Artemisinin derivatives restricted?
