Podcast
Questions and Answers
What is a common issue that can lead to an underpowered trial in a clinical trial?
What is a common issue that can lead to an underpowered trial in a clinical trial?
- Participants missing outcome data (correct)
- Incorrect measurement of the primary outcome variable
- Incorrect randomization of participants
- Incorrect calculation of the standard deviation
What is the intention-to-treat principle in clinical trials?
What is the intention-to-treat principle in clinical trials?
- Analyzing only participants who showed improvement
- Analyzing participants based on the treatment they actually received
- Analyzing only participants who completed the trial
- Analyzing participants based on the treatment they were randomized to (correct)
Why should sample size be specified in the grant application and protocol?
Why should sample size be specified in the grant application and protocol?
- To ensure that the trial is funded
- To ensure that the trial is adequately powered (correct)
- To ensure that the trial is completed quickly
- To ensure that the trial is ethical
What is the recommended pilot trial sample size per treatment arm for a medium standardised effect size?
What is the recommended pilot trial sample size per treatment arm for a medium standardised effect size?
What is the purpose of inflating the sample size in a clinical trial?
What is the purpose of inflating the sample size in a clinical trial?
What is the primary purpose of a pilot trial in clinical trial design?
What is the primary purpose of a pilot trial in clinical trial design?
What is the relationship between the sample size needed at recruitment and the retention rate at the primary follow-up timepoint?
What is the relationship between the sample size needed at recruitment and the retention rate at the primary follow-up timepoint?
Why is formal hypothesis testing for effectiveness not recommended in a pilot trial?
Why is formal hypothesis testing for effectiveness not recommended in a pilot trial?
Why is sample size calculation considered an educated guess?
Why is sample size calculation considered an educated guess?
What is the recommended sample size for estimating a participation rate of 50% to within a 95% confidence interval of +/-10%?
What is the recommended sample size for estimating a participation rate of 50% to within a 95% confidence interval of +/-10%?
What is the purpose of estimating a sample size for a pilot trial?
What is the purpose of estimating a sample size for a pilot trial?
Why should the size of a pilot trial be large enough?
Why should the size of a pilot trial be large enough?
What is the primary objective of performing sample size calculations in a clinical trial?
What is the primary objective of performing sample size calculations in a clinical trial?
What is the purpose of power calculations in a clinical trial?
What is the purpose of power calculations in a clinical trial?
What is the main reason for conducting sample size calculations in a clinical trial?
What is the main reason for conducting sample size calculations in a clinical trial?
What is the role of the sample size calculation in a clinical trial?
What is the role of the sample size calculation in a clinical trial?
What is the consequence of underestimating the sample size in a clinical trial?
What is the consequence of underestimating the sample size in a clinical trial?
What is the relationship between the sample size and the power of a clinical trial?
What is the relationship between the sample size and the power of a clinical trial?
