Clinical Questions on ENT and Immunology
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Questions and Answers

What is the most common cause of otitis externa?

  • Streptococcus pneumoniae
  • Staphylococcus aureus
  • Pseudomonas (correct)
  • Escherichia coli
  • Which treatment is appropriate for cerumen buildup?

  • Topical ciprofloxacin + hydrocortisone drops
  • Carbamide peroxide drops (correct)
  • Amoxicillin
  • Topical alcohol-acetic acid drops
  • In a young child with mastoiditis, what is the recommended imaging study?

  • X-ray
  • CT of the temporal bone (correct)
  • MRI of the ear
  • Ultrasound
  • What is the initial treatment for acute otitis media?

    <p>Amoxicillin (A)</p> Signup and view all the answers

    Which antibiotic is recommended for aspiration pneumonia or pulmonary abscess?

    <p>Clindamycin (C)</p> Signup and view all the answers

    What condition is associated with a patient experiencing temperature dysesthesia after consuming reef fish?

    <p>Ciguatera toxicity (D)</p> Signup and view all the answers

    What is the likely diagnosis for a patient who has no previous history of allergies and develops dyspnea after consuming meaty fish in a tropical location?

    <p>Scombroid reaction (B)</p> Signup and view all the answers

    If a patient develops an allergic-like reaction after eating shellfish, what is the most appropriate diagnosis?

    <p>Shellfish allergy (D)</p> Signup and view all the answers

    What causes vomiting a few hours after consuming meat?

    <p>S.aureus preformed heat-stable toxin (A)</p> Signup and view all the answers

    In the context of foodborne illnesses, what is the most likely cause of vomiting after eating custards or creams?

    <p>S.aureus preformed heat-stable toxin (B)</p> Signup and view all the answers

    What is the most common immunodeficiency in humans?

    <p>IgA deficiency (B)</p> Signup and view all the answers

    Which of the following conditions is associated with IgA deficiency?

    <p>Anaphylaxis after blood transfusion (C)</p> Signup and view all the answers

    In the diagnosis of Celiac disease for a patient with IgA deficiency, which test is unreliable?

    <p>IgA anti-tissue transglutaminase (A)</p> Signup and view all the answers

    What clinical feature may suggest chronic mucocutaneous candidiasis in a young female with autoimmune disorders?

    <p>Candidal infections since childhood (B)</p> Signup and view all the answers

    When should steroids be added to TMP/SMX for a patient with PJP pneumonia?

    <p>When A-a gradient is greater than 35 (B)</p> Signup and view all the answers

    Which chromosome is associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD)?

    <p>Chromosome 16 (B)</p> Signup and view all the answers

    In the management of suspected meningitis, what does the new guideline recommend to perform first?

    <p>Perform a lumbar puncture (C)</p> Signup and view all the answers

    What is the most common extra-renal location for cysts in patients with polycystic kidney disease?

    <p>Liver (B)</p> Signup and view all the answers

    Which of the following is NOT recommended for screening in patients with Autosomal Dominant Polycystic Kidney Disease?

    <p>MR angiogram of the Circle of Willis (D)</p> Signup and view all the answers

    In the pediatric context, what significant complication is associated with Autosomal Recessive Polycystic Kidney Disease (ARPKD)?

    <p>Hepatic fibrosis (D)</p> Signup and view all the answers

    What is a key difference between bacterial meningitis and viral (aseptic) meningitis?

    <p>Bacterial meningitis typically has high protein and low glucose. (C)</p> Signup and view all the answers

    Which symptom is primarily associated with encephalitis but not meningitis?

    <p>Confusion (B)</p> Signup and view all the answers

    In the diagnosis of Cryptococcal meningitis, which test is preferred if available?

    <p>Latex agglutination (C)</p> Signup and view all the answers

    What is the main treatment approach for Cryptococcal meningitis?

    <p>Amphotericin B + flucytosine followed by fluconazole taper (B)</p> Signup and view all the answers

    If a CT scan is negative but symptoms suggest a potential mass lesion, what should be done with caution regarding lumbar puncture (LP)?

    <p>Careful evaluation is necessary to avoid tonsillar herniation. (A)</p> Signup and view all the answers

    Flashcards

    IgA deficiency

    A common immunodeficiency characterized by recurrent sinopulmonary infections, especially in older children, that may be accompanied by autoimmune phenomena (e.g., atopy, vitiligo) and gastrointestinal issues like Giardia infections.

    Chronic Mucocutaneous Candidiasis (CMC)

    A rare, primary immunodeficiency disorder characterized by chronic, recurrent candidal infections, typically beginning early in life.

    Bronchoalveolar Lavage

    A diagnostic procedure involving the collection and analysis of fluid from the alveoli of the lungs, often used in the diagnosis of Pneumocystis jirovecii pneumonia (PJP).

    A-a Gradient

    An indicator of respiratory impairment and potential for worsening PJP, used to determine when to add steroids to TMP/SMX treatment.

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    Statin Eligibility Guidelines

    A widely used classification of statin eligibility based on age, LDL cholesterol levels, and diabetes status.

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    Otitis Externa

    Inflammation of the external ear canal, most commonly caused by Pseudomonas aeruginosa.

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    Malignant Otitis Externa

    A severe form of otitis externa that involves the mastoid bone, potentially leading to complications like brain abscess.

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    Otitis Media

    A common childhood ear infection that affects the middle ear.

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    Bronchiectasis

    A condition characterized by persistent, abnormal dilation of the bronchi, often caused by chronic infections or cystic fibrosis.

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    Aspiration Pneumonia

    A type of pneumonia caused by anaerobic bacteria, typically treated with clindamycin.

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    Ciguatera toxicity

    A food poisoning caused by consuming fish that contain ciguatoxin, a potent neurotoxin that blocks sodium channels. This can lead to symptoms like temperature dysesthesia, where hot feels cold and cold feels hot.

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    Scombroid poisoning

    A food poisoning caused by the accumulation of histamine in fish due to bacterial decomposition. This can cause allergic-like symptoms, such as dyspnea. It is often mistaken for a seafood allergy, but it's distinct from a true allergic reaction.

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    Staphylococcus aureus food poisoning

    A food poisoning caused by preformed heat-stable toxins produced by Staphylococcus aureus. These toxins are typically found in foods like meat, custards, creams, and potato salad and cause rapid onset of vomiting.

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    Shellfish allergy

    A true allergic reaction to shellfish, causing symptoms such as hives, itching, swelling, and respiratory distress. It can be life-threatening and requires prompt medical attention.

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    Bacterial food poisoning (bloody diarrhea type)

    Food poisoning caused by consuming food contaminated with bacteria such as EHEC, Yersinia enterocolitica, Campylobacter, Shigella, or Salmonella. These bacteria produce toxins that cause diarrhea, often with blood, and abdominal cramps. The onset of symptoms is typically within 1-3 days after ingestion.

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    Right Middle Lobe Syndrome

    A pediatric condition where the right middle lobe of the lung develops bronchiectasis due to persistent inflammation and infection. This is distinct from the typical presentation involving chronic coughing and foul-smelling sputum, often seen in adults. This condition may be associated with recurrent infections.

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    What is ARPKD?

    Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder causing multiple cysts in the kidneys, presenting in childhood and often leading to liver fibrosis.

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    What is ADPKD?

    Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder causing multiple cysts in the kidneys, usually presenting in adulthood, often starting to become symptomatic around 30-40 years old.

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    What is the initial screening for ADPKD?

    Serial blood pressure checks are the primary screening method for patients with ADPKD. MR angiogram is only recommended if they have a family history of aneurysm.

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    What is the most common extra-renal site for cysts in ADPKD?

    The most common extra-renal site for cysts in patients with ADPKD is the liver.

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    When to avoid a lumbar puncture?

    A neurologic exam should not be performed when there's a suspected mass lesion because a lumbar puncture (LP) could cause tonsillar herniation and death. Signs for a potential mass lesion include confusion that interferes with the exam, a decreased Glasgow Coma Scale (GCS) score, a seizure, focal neurologic signs (motor or sensory), papilledema, or an inability to visualize the optic fundi.

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    What are the CSF findings in bacterial meningitis?

    Characterized by low glucose, high protein, and high neutrophils (polymorphonuclear cells or PMNs) in the cerebrospinal fluid (CSF).

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    What are the CSF findings in aseptic (viral) meningitis?

    Characterized by normal glucose, normal (or slightly elevated) protein, and high lymphocytes in the CSF.

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    What are the CSF findings and neuroimaging in Herpes encephalitis?

    Characterized by lots of red blood cells (RBCs) in the CSF due to temporal lobe hemorrhage. CT is often negative, but EEG sometimes shows wave slowing or temporal complexes.

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    How is Cryptococcal meningitis diagnosed and treated?

    Cryptococcal meningitis is diagnosed using latex agglutination if it's listed as an option. Alternatively, mucicarmine staining can also be performed. The treatment involves amphotericin B + flucytosine, followed by a fluconazole taper.

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    Study Notes

    Hot Feels Cold, Cold Feels Hot

    • Temperature dysesthesia is a symptom of ciguatera toxicity
    • This toxin blocks sodium channels in nerve cells
    • Caused by eating reef fish like mahimahi or Spanish mackerel

    Scombroid

    • Histamine is a toxin from decaying fish
    • Histidine decarboxylase in decaying fish converts histidine to histamine
    • Allergic-like reaction can result from eating fish high in histamine
    • Often misdiagnosed as a normal seafood allergy
    • Results in symptoms like dyspnea (shortness of breath)

    Shellfish Allergy

    • Symptoms can include allergic-like reactions after eating shellfish
    • It is important to differentiate from scombroid symptoms

    Staph Aureus

    • A preformed heat-stable toxin from S. aureus
    • Can cause vomiting several hours after eating contaminated food
    • Food sources often include custard, creams, potato salad

    Otitis Externa

    • Ciprofloxacin + hydrocortisone drops are a common treatment
    • Alcohol-acetic acid drops can prevent otitis externa in people frequently exposed to water
    • Pseudomonas is a common cause of otitis externa
    • Malignant otitis externa is a significant complication if not treated properly and requires CT or MRI of the temporal bone

    Bronchiectasis

    • A chronic lung disease characterized by abnormal widening of the bronchial tubes
    • Sputum often is scant but white and has a linear opacity on X-ray in the right mid-lobe
    • Common causes include cystic fibrosis and tuberculosis

    ADPKD and ARPKD

    • ADPKD and ARPKD are conditions that have a risk for high blood pressure and cysts.
    • Chromosome 6 is related to ARPKD
    • Chromosome 16 is related to ADPKD
    • Cysts in the liver are also common in ARPKD and ADPKD

    Meningitis

    • Bacterial meningitis is characterized by low glucose, high protein, and high neutrophils
    • Aseptic meningitis (viral) has normal glucose, normal proteins, and high lymphocytes.
    • Fungal meningitis has low glucose, high protein, and high lymphocytes.
    • Herpes encephalitis can be characterized by RBCs in the CSF.

    Cryptococcal Meningitis

    • Diagnosis can be made via latex agglutination or mucicarmine staining
    • Treatment often includes amphotericin B & flucytosine, followed by fluconazole taper
    • Can affect immunocompromised individuals

    Otitis Media

    • Usually treated with amoxicillin

    Meningitis

    • Empiric treatment for meningitis is often ceftriaxone/vancomycin, +/- steroids.
    • CT of the head may be considered before lumbar puncture if there is confusion that interferes with the neurologic exam, a seizure, or focal neurologic symptoms

    Autoimmune Diseases/Immunodeficiency

    • Autoimmune conditions can occur in association with immunodeficiencies, like IgA deficiency
    • Immunodeficiencies can cause autoimmune-related symptoms in some patients

    Thyroiditis

    • Autoimmune thyroiditis is common and often presents with an initial history of a chronic mucocutaneous candidiasis history

    Other Topics

    • Various topics including diagnoses and treatments related to various aspects of internal medicine are listed.

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    Description

    Test your knowledge on common ENT conditions and treatments, as well as aspects of immunology related to food allergies and infections. This quiz covers a range of questions from otitis externa to immunodeficiency disorders. Perfect for students and professionals in the medical field.

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