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Clinical Pharmacokinetics of Local Anaesthetics

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Clinical Pharmacokinetics of Local Anaesthetics

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Questions and Answers

What is the primary mechanism of action of local anesthetic agents?

Blockade of sodium channels in the neuronal membrane (correct)

Inhibition of the release of neurotransmitters from nerve terminals

Enhancement of the activity of GABA receptors

Stimulation of the release of acetylcholine from nerve terminals

Which of the following is a characteristic of amide-type local anesthetic agents?

They are hydrolyzed by liver enzymes

They are metabolized by plasma cholinesterase

They have a higher potency and longer duration of action (correct)

They are more susceptible to allergic reactions

What is the primary factor that determines the duration of action of a local anesthetic agent?

The rate of absorption from the site of injection (correct)

The binding affinity to plasma proteins

The rate of metabolism by the liver

The degree of ionization of the agent

Which of the following is a clinical application of local anesthetic agents in the management of chronic pain?

<p>Nerve stimulation for the diagnosis of complex regional pain syndrome</p> Signup and view all the answers

What is the term used to describe the increase in the minimum alveolar concentration (MAC) of a volatile anesthetic agent required to produce immobility in response to a surgical stimulus, in the presence of a local anesthetic agent?

<p>Anesthesia-sparing effect</p> Signup and view all the answers

Clinical Pharmacokinetics of Local Anaesthetics

Choose a study mode

Podcast

Questions and Answers

What is the primary mechanism of action of local anesthetic agents?

Which of the following is a characteristic of amide-type local anesthetic agents?

What is the primary factor that determines the duration of action of a local anesthetic agent?

Which of the following is a clinical application of local anesthetic agents in the management of chronic pain?

What is the term used to describe the increase in the minimum alveolar concentration (MAC) of a volatile anesthetic agent required to produce immobility in response to a surgical stimulus, in the presence of a local anesthetic agent?

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