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Questions and Answers
What is the primary mechanism of action of local anesthetic agents?
What is the primary mechanism of action of local anesthetic agents?
- Blockade of sodium channels in the neuronal membrane (correct)
- Inhibition of the release of neurotransmitters from nerve terminals
- Enhancement of the activity of GABA receptors
- Stimulation of the release of acetylcholine from nerve terminals
Which of the following is a characteristic of amide-type local anesthetic agents?
Which of the following is a characteristic of amide-type local anesthetic agents?
- They are hydrolyzed by liver enzymes
- They are metabolized by plasma cholinesterase
- They have a higher potency and longer duration of action (correct)
- They are more susceptible to allergic reactions
What is the primary factor that determines the duration of action of a local anesthetic agent?
What is the primary factor that determines the duration of action of a local anesthetic agent?
- The rate of absorption from the site of injection (correct)
- The binding affinity to plasma proteins
- The rate of metabolism by the liver
- The degree of ionization of the agent
Which of the following is a clinical application of local anesthetic agents in the management of chronic pain?
Which of the following is a clinical application of local anesthetic agents in the management of chronic pain?
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What is the term used to describe the increase in the minimum alveolar concentration (MAC) of a volatile anesthetic agent required to produce immobility in response to a surgical stimulus, in the presence of a local anesthetic agent?
What is the term used to describe the increase in the minimum alveolar concentration (MAC) of a volatile anesthetic agent required to produce immobility in response to a surgical stimulus, in the presence of a local anesthetic agent?
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