Clinical Laboratory Quiz on Urine and CBC
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Questions and Answers

If your patient has tubulointerstitial disease, which type of urine casts will be seen in the sediment?

  • Waxy casts
  • Erythrocyte casts
  • Leukocyte casts (correct)
  • Hyaline casts

The urine protein dipsticks are most sensitive for?

  • Bens-Jones protein
  • Albumin (correct)
  • Globulins
  • Tamm-Horsfall mucoprotein

Which parameter from CBC will be used to determine an anisocytosis?

  • MCH
  • RBC
  • MCV
  • RDW (correct)

Normal individual excretes <0.15 g/d of total protein and <0.03 g/d of albumin. Knowing that you define the term microalbuminuria?

<p>Albumin in the urine 0.03 – 0.3 g/d (B)</p> Signup and view all the answers

If your patient has uncompensated metabolic acidosis what shall we expect from his laboratory research?

<p>↓↓pH, = CO2, ↓↓↓ HCO3 (C)</p> Signup and view all the answers

Which bilirubin would be increased if your patient has bilirubinuria?

<p>Conjugated (B)</p> Signup and view all the answers

Which enzyme is most specific for diagnosis of liver disease?

<p>ALT (B)</p> Signup and view all the answers

If your patient has glomerulonephritis, which type of urine casts will be seen in the sediment?

<p>Erythrocytes casts (A)</p> Signup and view all the answers

Which type of test we use to detect bacteria in urine?

<p>For nitrites (B)</p> Signup and view all the answers

Which parameter from CBC will be used to determine an infectious disease?

<p>WBC (C)</p> Signup and view all the answers

Which parameter from CBC will be used to diagnose anaemia?

<p>A, C, and D (C)</p> Signup and view all the answers

Normal individual excretes <0.15 g/d of total protein and <0.03 g/d of albumin. Knowing that you define the term proteinuria?

<p>Albumin in the urine 0.3 – 3.5 g/d (C)</p> Signup and view all the answers

Iron deficiency anaemia is characterised with?

<p>Low RBC, low haemoglobin and low MCV (D)</p> Signup and view all the answers

Pernicious anaemia is characterised by?

<p>Low MCV (A)</p> Signup and view all the answers

Write the laboratory parameter to monitor patients on anticoagulant therapy with warfarin?

<p>Prothrombin time</p> Signup and view all the answers

If your patient has partially compensated respiratory acidosis what shall we expect from his laboratory research?

<p>↓pH, ↑↑ CO2, ↑↑ HCO3 (C)</p> Signup and view all the answers

Which laboratory parameter are used to monitor patients on anticoagulant therapy with heparin?

<p>APTT (B)</p> Signup and view all the answers

Flashcards

Tubulointerstitial disease urine casts

Waxy casts are typically seen in the urine sediment of patients with tubulointerstitial disease.

Urine protein dipstick sensitivity

Urine protein dipsticks are most sensitive to albumin.

Anisocytosis in CBC

Red cell distribution width (RDW) in a complete blood count (CBC) is used to detect anisocytosis.

Leukocyte casts in

Leukocyte casts appear in the urine sediment of patients with infections or inflammation.

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Erythrocyte casts in

Erythrocyte casts appear in the urine of patients with glomerular injury or inflammation.

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Hyaline casts in

Hyaline casts are common and can be found in normal urine.

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MCH

Mean corpuscular hemoglobin (MCH), Indicates the average amount of hemoglobin per red blood cell.

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RBC

Red blood cell count, measures the number of red blood cells in the blood.

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MCV

Mean corpuscular volume (MCV); measures the average size of red blood cells in blood.

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Bens-Jones protein

Bence Jones protein is a type of immunoglobulin light chain and is not commonly detected by urine protein dipsticks because it is filtered poorly.

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Tubulointerstitial disease casts

Waxy casts are seen in the urine sediment of patients with tubulointerstitial disease. These casts are broad, smooth and have a waxy appearance.

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Leukocyte casts in urine

Leukocyte casts appear in the urine sediment of patients with infections or inflammation in the kidney tubules. They are made of white blood cells.

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Erythrocyte casts in urine

Erythrocyte casts appear in the urine of patients with glomerular injury or inflammation. These casts are made of red blood cells.

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Hyaline casts in urine

Hyaline casts are common and can be found in normal urine. They are transparent and made of a protein called Tamm-Horsfall mucoprotein.

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What does MCH measure?

Mean corpuscular hemoglobin (MCH) measures the average amount of hemoglobin in a red blood cell. This helps determine the oxygen-carrying capacity of red blood cells.

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What does MCV measure?

Mean corpuscular volume (MCV) is a measure of the average volume or size of red blood cells in a sample of blood.

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Bens-Jones protein detection

Bence Jones protein is a type of immunoglobulin light chain and is not commonly detected by urine protein dipsticks because it is filtered poorly.

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What does a normal individual excrete?

A normal individual excretes urine with very little protein, less than 150mg per day, and no glucose.

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Study Notes

Clinical Laboratory

  • Urine Casts and Tubulointerstitial Disease: Leukocyte casts are observed in cases of tubulointerstitial disease.
  • Urine Protein Dipsticks: Dipsticks are most sensitive to albumin.
  • Complete Blood Count (CBC): Red Cell Distribution Width (RDW) parameter in CBC is used for anisocytosis assessment.
  • Microalbuminuria: Albumin in the urine, 0.03-0.3 g/day is termed as microalbuminuria
  • Metabolic Acidosis: Uncompensated metabolic acidosis shows decreased pH, normal CO2, and a severely decreased HCO3.
  • Bilirubinuria: Conjugated bilirubin increases in bilirubinuria.
  • Liver Function Tests: Alanine aminotransferase (ALT) is the most specific enzyme for diagnosing liver disease.
  • Glomerulonephritis: Erythrocyte casts are seen in the sediment of patients with glomerulonephritis.

Additional Notes

  • Normal Proteinuria: A normal individual excretes less than 0.15 g/day of total protein and less than 0.03 g/day of albumin.
  • Iron Deficiency Anemia: Characterized by low red blood cells (RBC), low hemoglobin, and low mean corpuscular volume (MCV).
  • Pernicious Anemia: Characterized by a high mean corpuscular volume (MCV).
  • Warfarin Therapy Monitoring: Prothrombin time (PT) and activated partial thromboplastin time (aPTT) used to monitor the anticoagulant warfarin.
  • Respiratory Acidosis: Partially compensated respiratory acidosis is indicated by a decreased pH, increased CO2, and normal HCO3.
  • Respiratory Alkalosis: Partially compensated respiratory alkalosis shows increased pH, decreased CO2, and normal HCO3.
  • Metabolic Alkalosis: Uncompensated metabolic alkalosis shows increased pH, normal CO2 , increased HCO3.
  • Metabolic Acidosis: Compensated metabolic acidosis shows decreased pH, decreased or normal CO2, decreased HCO3.
  • Acid-Base Disorders: Acidosis is an abnormal condition causing a decrease in arterial pH. Alkalosis is an abnormal condition causing an increase in arterial pH. Simple acid-base disorders are those with a single primary cause, whereas mixed acid-base disorders have multiple causes.
  • Glomerular Filtration Rate (GFR): GFR is assessed more reliably by calculating creatinine clearance using a formula, and considering serum and urine creatinine concentration along with urine volume.
  • Bacteria in Urine: Nitrite test is used to detect bacteria in urine.
  • Anemia Diagnosis: Hemoglobin, hematocrit, and RBC are parameters used to diagnose anemia.
  • Infectious Disease Diagnosis: White blood cells (WBC) are used to diagnose infectious diseases.

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Description

This quiz explores key concepts in clinical laboratory testing, focusing on urine casts, dipsticks, and blood counts. Topics include mechanisms behind various urine conditions, metabolic acidosis, and liver function tests. Test your knowledge on these critical laboratory findings and their interpretations.

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