Podcast
Questions and Answers
What histological feature is suggested by direct immunofluorescence in cases where differential diagnosis is difficult?
What histological feature is suggested by direct immunofluorescence in cases where differential diagnosis is difficult?
What is the expression of chemokines, specifically regulated by interferons, in relation to CLE?
What is the expression of chemokines, specifically regulated by interferons, in relation to CLE?
In which scenario is direct immunofluorescence of non-lesional skin not recommended?
In which scenario is direct immunofluorescence of non-lesional skin not recommended?
What type of cell predominates in the lymphoid infiltration associated with CLE?
What type of cell predominates in the lymphoid infiltration associated with CLE?
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Which abnormality is associated with the histology of acute cutaneous lupus erythematosus (ACLE)?
Which abnormality is associated with the histology of acute cutaneous lupus erythematosus (ACLE)?
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Which of the following institutions is associated with pediatric rheumatology?
Which of the following institutions is associated with pediatric rheumatology?
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What is the role of the Hamburg Center for Pediatric and Adolescent Rheumatology?
What is the role of the Hamburg Center for Pediatric and Adolescent Rheumatology?
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Which of the following departments is NOT mentioned as related to rheumatology?
Which of the following departments is NOT mentioned as related to rheumatology?
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Which city hosts the department of Dermatology and Venereology associated with the Vivantes Klinikum Neukölln?
Which city hosts the department of Dermatology and Venereology associated with the Vivantes Klinikum Neukölln?
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What type of specialties does the Clinic and Functional Division for Rheumatology at University Hospital Düsseldorf cover?
What type of specialties does the Clinic and Functional Division for Rheumatology at University Hospital Düsseldorf cover?
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What is the primary focus of the studies mentioned in the content?
What is the primary focus of the studies mentioned in the content?
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Which study design was utilized in examining the photoprotective effects of broad-spectrum sunscreen?
Which study design was utilized in examining the photoprotective effects of broad-spectrum sunscreen?
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Which organization published updated classification criteria for systemic lupus erythematosus?
Which organization published updated classification criteria for systemic lupus erythematosus?
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What outcome instrument was developed for assessing cutaneous lupus erythematosus?
What outcome instrument was developed for assessing cutaneous lupus erythematosus?
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What is a rare potential complication associated with healed scars of cutaneous lupus erythematosus?
What is a rare potential complication associated with healed scars of cutaneous lupus erythematosus?
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What treatment approach was highlighted for managing systemic lupus erythematosus?
What treatment approach was highlighted for managing systemic lupus erythematosus?
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Which condition is directly linked to ultraviolet exposure according to the content?
Which condition is directly linked to ultraviolet exposure according to the content?
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What percentage of cases does discoid lupus erythematosus (DLE) present as the first sign of systemic lupus erythematosus (SLE)?
What percentage of cases does discoid lupus erythematosus (DLE) present as the first sign of systemic lupus erythematosus (SLE)?
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Which clinical appearance characterizes lupus erythematosus tumidus (LET)?
Which clinical appearance characterizes lupus erythematosus tumidus (LET)?
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What was one of the methods used to assess disease activity in systemic lupus erythematosus?
What was one of the methods used to assess disease activity in systemic lupus erythematosus?
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What is a potential benefit of using sunscreen in patients with cutaneous lupus erythematosus?
What is a potential benefit of using sunscreen in patients with cutaneous lupus erythematosus?
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Which of the following describes the typical healing outcome of lupus erythematosus tumidus (LET) lesions?
Which of the following describes the typical healing outcome of lupus erythematosus tumidus (LET) lesions?
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What is a characteristic location for lesions of lupus erythematosus profundus (LEP)?
What is a characteristic location for lesions of lupus erythematosus profundus (LEP)?
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What percentage of patients with lupus erythematosus tumidus (LET) display positive results in a photo-provocation test?
What percentage of patients with lupus erythematosus tumidus (LET) display positive results in a photo-provocation test?
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What kind of antibodies are typically absent in lupus erythematosus tumidus (LET)?
What kind of antibodies are typically absent in lupus erythematosus tumidus (LET)?
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Which of the following is a notable characteristic of the lesions found in lupus erythematosus profundus (LEP)?
Which of the following is a notable characteristic of the lesions found in lupus erythematosus profundus (LEP)?
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What can the presence of anti-ds-DNA antibodies indicate in cutaneous lupus erythematosus?
What can the presence of anti-ds-DNA antibodies indicate in cutaneous lupus erythematosus?
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Which of the following is NOT frequently associated with lupus erythematosus tumidus (LET)?
Which of the following is NOT frequently associated with lupus erythematosus tumidus (LET)?
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Which index is used as a responsive instrument to measure activity and damage in patients with cutaneous lupus erythematosus?
Which index is used as a responsive instrument to measure activity and damage in patients with cutaneous lupus erythematosus?
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What does the revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI) modify?
What does the revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI) modify?
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What condition is associated with incidental cases of subacute cutaneous lupus erythematosus?
What condition is associated with incidental cases of subacute cutaneous lupus erythematosus?
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Which haplotype is considered an independent risk factor for cutaneous lupus erythematosus?
Which haplotype is considered an independent risk factor for cutaneous lupus erythematosus?
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What year was the update of the EULAR recommendations for managing systemic lupus erythematosus published?
What year was the update of the EULAR recommendations for managing systemic lupus erythematosus published?
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Which of the following studies expanded the Cutaneous Lupus Erythematosus Disease Activity and Severity Index for rheumatology and dermatology?
Which of the following studies expanded the Cutaneous Lupus Erythematosus Disease Activity and Severity Index for rheumatology and dermatology?
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Which evaluation method assesses disease activity and damage in different subtypes of cutaneous lupus erythematosus?
Which evaluation method assesses disease activity and damage in different subtypes of cutaneous lupus erythematosus?
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Which year was the study on polymorphic light eruption and its independent risk factors for cutaneous lupus erythematosus published?
Which year was the study on polymorphic light eruption and its independent risk factors for cutaneous lupus erythematosus published?
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Study Notes
Institutions Involved
- Charité – Universitätsmedizin Berlin is a leading medical institution in Germany.
- Collaborating institutions include Free University of Berlin, Humboldt University of Berlin, and Berlin Institute of Health.
- Other significant affiliations include Vivantes Klinikum Neukölln, University Hospital Düsseldorf, Hamburg Center for Pediatric and Adolescent Rheumatology, and Technical University of Dresden.
Cutaneous Lupus Erythematosus (CLE)
- Rarely, squamous cell carcinoma may arise from healed scars associated with CLE.
- Discoid lupus erythematosus (DLE) appears in 10% of cases as the initial sign of systemic lupus erythematosus (SLE).
Clinical Features of Lupus Erythematosus Tumidus (LET)
- Characterized by succulent, indurated, urticarial-like erythematous plaques, smooth-surfaced and not involving the epidermis.
- Commonly observed in sun-exposed areas such as the face, upper trunk, and arms.
- Healing typically occurs without scarring or pigment alterations.
Lupus Erythematosus Profundus (LEP)
- Presents as subcutaneous nodular or discoid lesions that are firm and can adhere to the skin.
- Predilection sites include gluteal areas and thighs, often presenting with erythema and potential for ulceration or calcification.
- Up to 75% of cases show positive antinuclear antibodies (ANA), with spontaneous remission occurring frequently.
Diagnostic Insights
- Direct immunofluorescence (DIF) shows interface dermatitis and hydropic degeneration of the basal epidermis; indicated especially in difficult differential diagnoses.
- Strong expression of chemokines regulated by interferons is observed in CLE.
Photosensitivity and Antibodies
- High photosensitivity recorded in over 70% of patients through positive provocation tests with UVA/UVB.
- Anti-Ro/SSA and anti-La/SSB antibodies found in approximately 5% of cases.
Histological Findings
- Direct immunofluorescence testing of non-affected skin exposed to sunlight is not recommended.
- Lymphoid infiltrate includes plasmacytoid dendritic cells and T cells, with significant dermal mucin deposits noted.
Miscellaneous
- Evaluation and management recommendations follow 2019 EULAR guidelines on systemic lupus erythematosus.
- Research includes classifications and severity indices relevant for dermatology and rheumatology practices.
These study notes compile essential facts regarding cutaneous lupus erythematosus pathology, presentations, and associated diagnostic and histological features.
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Description
Explore the clinical features and institutions involved in the study of Cutaneous Lupus Erythematosus (CLE) and Lupus Erythematosus Tumidus (LET). This quiz highlights the associations between lupus and other medical conditions, as well as key research institutions in Germany. Test your knowledge about the significance and manifestations of these rare skin conditions.
