Clinical and Molecular Diagnostics Lecture 2

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Questions and Answers

What is a common cause of Leukocytosis?

  • Hemolytic anemia
  • Bone marrow disorders
  • Dental caries
  • Thyroid problems (correct)

Which of the following is NOT a cause of Leukopenia?

  • Smoking (correct)
  • Bone marrow disorders
  • Cancer
  • Autoimmune diseases

What is the main difference between Reactive Thrombocytosis and Essential Thrombocythemia?

  • One is more common in men, the other in women
  • One is acute, the other chronic
  • One is caused by medical problems, the other by genetic changes (correct)
  • One causes bleeding, the other clotting

Which of the following is a cause of Neutrophilia?

<p>Tissue damage (D)</p> Signup and view all the answers

What is a common cause of Thrombocytosis?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a cause of Leukocytosis?

<p>Corticosteroids (A)</p> Signup and view all the answers

What is a common cause of Neutropenia?

<p>Viral infections (A)</p> Signup and view all the answers

What is the main difference between Leukocytosis and Leukopenia?

<p>One increases white blood cell count, the other decreases it (B)</p> Signup and view all the answers

What is a common cause of lymphocytosis in children?

<p>Viral infections such as whooping cough, mumps, and measles (D)</p> Signup and view all the answers

What is a common cause of monocytosis?

<p>Chronic bacterial infections such as tuberculosis (D)</p> Signup and view all the answers

What is a common cause of eosinophilia?

<p>Allergic conditions such as asthma and hay fever (B)</p> Signup and view all the answers

What is a common cause of lymphocytopenia?

<p>HIV/AIDS (D)</p> Signup and view all the answers

What is a common cause of basophilia?

<p>Allergic reactions (A)</p> Signup and view all the answers

What is a common cause of splenomegaly?

<p>Brucellosis (D)</p> Signup and view all the answers

What is the classification of anemia based on a hemoglobin value of 9.0 g/dL?

<p>Moderate (D)</p> Signup and view all the answers

What is the most common cause of microcytic anemia?

<p>Iron deficiency (C)</p> Signup and view all the answers

What is the classification of anemia based on an MCV value?

<p>Normocytic, microcytic, and macrocytic (A)</p> Signup and view all the answers

What is the most common cause of the acquired form of normocytic anemia?

<p>Chronic disease (B)</p> Signup and view all the answers

What is the classification of anemia based on an MCH value?

<p>Hypochromic, normochromic, and hyperchromic (B)</p> Signup and view all the answers

What is the hemoglobin value range for mild anemia?

<p>10.0 to lower limit of normal (B)</p> Signup and view all the answers

What is the common cause of anemia that can be caused by inadequate iron intake or inability to absorb iron?

<p>Iron deficiency anemia (C)</p> Signup and view all the answers

What is the classification of anemia based on hemoglobin value of 7.0 g/dL?

<p>Severe (C)</p> Signup and view all the answers

What is the common cause of anemia in women due to chronic blood loss?

<p>Frequent or heavy periods (B)</p> Signup and view all the answers

What is the type of anemia caused by an inherited abnormality?

<p>Thalassemia (C)</p> Signup and view all the answers

What is the cause of megaloblastic anemia?

<p>Vitamin B-12 deficiency (A)</p> Signup and view all the answers

What is the term for an increase in the number of red blood cells?

<p>Erythrocytosis (C)</p> Signup and view all the answers

What is a common cause of Erythrocytopenia?

<p>All of the above (D)</p> Signup and view all the answers

What is the term for an increase in the number of white blood cells?

<p>Leukocytosis (D)</p> Signup and view all the answers

What is the term for a decrease in the number of platelets?

<p>Thrombocytopenia (C)</p> Signup and view all the answers

What is the cause of non-megaloblastic macrocytic anemia?

<p>All of the above (D)</p> Signup and view all the answers

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Study Notes

Blood Sampling (Phlebotomy)

  • Types of blood sampling tubes: plain serum tube, ESR tubes
  • Heel blood sampling

Complete Blood Count (CBC)

  • Blood indices:
    • Depend on hemoglobin value: mild (10.0 g/dL to lower limit of normal), moderate (8.0 to 10.0 g/dL), severe (6.5 to 7.9 g/dL), life-threatening (less than 6.5 g/dL)
    • Depend on MCV value: normocytic, microcytic, macrocytic
    • Depend on MCH value: normochromic, hypochromic, hyperchromic

Types and Common Causes of Anemia

  • Normochromic normocytic anemia: chronic diseases (kidney disease, cancer, rheumatoid arthritis, thyroiditis)
  • Hypochromic microcytic anemia: iron deficiency anemia, thalassemia
  • Normochromic or hypochromic macrocytic anemia: megaloblastic (vitamin B-12 deficiency or folate deficiency), non-megaloblastic (chronic alcohol use disorder, liver disease, hypothyroidism)

Important Terms

  • RBCs: erythrocytes, erythrocytopenia, erythrocytosis (polycythemia)
  • WBCs: leucocytes, leukocytosis, leukocytopenia, neutrophilia, neutropenia, eosinophilia, eosinopenia
  • Platelets: thrombocytes, thrombocytosis, thrombocytopenia

Causes of Erythrocytosis

  • Smoking
  • Drinking too much alcohol
  • Certain medicines
  • Chronic heart, lung, kidney, or liver disease

Causes of Erythrocytopenia

  • Vitamin or mineral deficiency
  • Low iron levels
  • Major organ problems
  • Red blood cells destroyed by the body
  • Loss of RBCs in hemorrhage

Causes of Leukocytosis

  • Excessive physical or emotional stress
  • Burns
  • Immune system disorders
  • Smoking
  • Obesity
  • Thyroid problems
  • Dental caries
  • Certain medicines
  • Allergies
  • Splenectomy

Causes of Leukocytopenia

  • Bone marrow disorders
  • Autoimmune diseases
  • Infections
  • HIV
  • Medications

Causes of Thrombocytosis

  • Reactive thrombocytosis: blood loss, cancer, infections, iron deficiency
  • Essential thrombocythemia: genetic changes, increased platelet production

Causes of Neutrophilia

  • Acute bacterial infections
  • Tissue damage
  • Acute myocardial infarction
  • Acute hemorrhage
  • Malignant diseases

Causes of Neutropenia

  • Viral infections
  • Bacterial infections
  • Splenomegaly
  • Megaloblastic anemia
  • Bone marrow failure

Causes of Lymphocytosis

  • Viral infections
  • Bacterial infections
  • Infectious mononucleosis
  • Cytomegalovirus infection
  • Lymphocytic leukemia, lymphomas

Causes of Lymphocytopenia

  • HIV/AIDS
  • Severe bone marrow failure
  • Covid-19 infection

Causes of Monocytosis

  • Chronic bacterial infections
  • Tuberculosis
  • Bacterial endocarditis

Causes of Eosinophilia

  • Helminth infections
  • Allergic conditions
  • Skin diseases

Causes of Basophilia

  • Allergic reactions
  • Chronic inflammation
  • Malignancies

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