Clean Room Design and Parenteral Nutrition Formulation Quiz

Malnutrition, a major risk factor for refeeding syndrome, is often observed in different disease states including cancer, Marasmus/Kwashiorkor, neurological problems, respiratory diseases, and gastrointestinal and liver diseases.

Upon refeeding, particularly with carbohydrate, the body quickly shifts back to carbohydrate metabolism, a state of anabolism, which can lead to the development of refeeding syndrome.

Good Manufacturing Practice (GMP) focuses on building quality into all working procedures to minimize the risk of errors. In aseptic units, GMP ensures the prevention against micro-organisms, thus maintaining the quality standards appropriate to their intended use and marketing authorization.

<p>The gravity fill method may pose higher risks for contamination since it relies on manual intervention. Consequently, the potential for introducing microorganisms is higher compared to automated compounded devices or vacuum fill chambers.</p> Signup and view all the answers

<p>Monitoring biochemistry closely in patients at risk of refeeding problems is essential to prevent complications. Electrolyte management, especially monitoring and correcting electrolyte imbalances, is crucial in maintaining fluid balance and preventing the development of refeeding syndrome.</p> Signup and view all the answers

<p>Maintaining lipid and chemical stability in parenteral nutrition formulations is crucial to avoid lipid peroxidation, precipitation, and degradation of active components, ensuring consistent efficacy and safety of the administered nutritional therapy.</p> Signup and view all the answers

<p>Precipitation, which poses a risk to the patient.</p> Signup and view all the answers

<p>Increasing pH, increasing Ca++ concentration, and increasing phosphate concentration.</p> Signup and view all the answers

<p>Creaming, characterized by the appearance of a visible layer of lipid droplets on top of the mixture.</p> Signup and view all the answers

<p>It increases the risk of calcium and phosphate precipitation.</p> Signup and view all the answers

<p>Refrigeration, and administration within 24 hours of rewarming.</p> Signup and view all the answers

<p>HEPA filter and clean room design, as well as hygiene and gowning.</p> Signup and view all the answers

<p>The result is the formation of a dense layer that cannot be redispersed, leading to the 'cracking' of the emulsion and visible free oil deposits on the surface of the mixture.</p> Signup and view all the answers

<p>To prevent degradation of the lipids and maintain chemical stability.</p> Signup and view all the answers

<p>48 hours, with 24 hours being the ideal hang time.</p> Signup and view all the answers

<p>Contamination and destabilization of the emulsion, leading to an unfit product.</p> Signup and view all the answers

<p>To prevent contamination and destabilization of the emulsion.</p> Signup and view all the answers

<p>To remove any air and prevent the introduction of air into the patient's bloodstream.</p> Signup and view all the answers