Podcast
Questions and Answers
What is the main mechanism of action of Amphotericin B?
What is the main mechanism of action of Amphotericin B?
- Blocking fungal cell division
- Disrupting fungal membrane permeability and transport properties (correct)
- Inhibiting fungal cell wall synthesis
- Preventing fungal nucleic acid synthesis
How is Amphotericin B usually administered for systemic infections?
How is Amphotericin B usually administered for systemic infections?
- Orally as an effective treatment for systemic disease
- Intramuscularly for rapid action
- Intravenously as a nonlipid colloidal suspension or in a liposomal formulation (correct)
- Under the skin (subcutaneously) for slow release
What is the bioavailability of oral Amphotericin B for systemic disease treatment?
What is the bioavailability of oral Amphotericin B for systemic disease treatment?
- Effective only on fungi within the gastrointestinal tract lumen (correct)
- Low, making it unsuitable for systemic disease treatment
- High, leading to rapid and effective systemic fungal infection treatment
- Moderate, requiring frequent dosing for optimal effects
Why is Amphotericin B not suitable for treatment of central nervous system (CNS) fungal infections?
Why is Amphotericin B not suitable for treatment of central nervous system (CNS) fungal infections?
How is Amphotericin B primarily eliminated from the body?
How is Amphotericin B primarily eliminated from the body?
What percentage of Amphotericin B is bound by serum proteins in the bloodstream?
What percentage of Amphotericin B is bound by serum proteins in the bloodstream?
What is the main mechanism of action of amphotericin B?
What is the main mechanism of action of amphotericin B?
Why does resistance to amphotericin B arise?
Why does resistance to amphotericin B arise?
Which fungal infection is NOT commonly treated with amphotericin B?
Which fungal infection is NOT commonly treated with amphotericin B?
What is a common toxic effect associated with amphotericin B colloidal formulations?
What is a common toxic effect associated with amphotericin B colloidal formulations?
How can infusion-related toxicity with amphotericin B be reduced?
How can infusion-related toxicity with amphotericin B be reduced?
What is the reason for using lipid formulations of amphotericin B?
What is the reason for using lipid formulations of amphotericin B?
What is the mechanism by which flucytosine exerts its antifungal activity?
What is the mechanism by which flucytosine exerts its antifungal activity?
What is the primary reason for combining flucytosine with amphotericin B during initiation treatment?
What is the primary reason for combining flucytosine with amphotericin B during initiation treatment?
How is flucytosine primarily excreted from the body?
How is flucytosine primarily excreted from the body?
What is the mechanism of resistance to flucytosine?
What is the mechanism of resistance to flucytosine?
Which of the following is NOT a potential toxicity associated with flucytosine?
Which of the following is NOT a potential toxicity associated with flucytosine?
For which fungal infection is flucytosine commonly used in combination with other antifungal agents?
For which fungal infection is flucytosine commonly used in combination with other antifungal agents?
Which class of azoles includes fluconazole?
Which class of azoles includes fluconazole?
What is a characteristic feature of fluconazole's bioavailability?
What is a characteristic feature of fluconazole's bioavailability?
For which fungal infection is fluconazole NOT effective according to the text?
For which fungal infection is fluconazole NOT effective according to the text?
What makes fluconazole the azole of choice for Cryptococcal meningitis and mucocutaneous candidiasis?
What makes fluconazole the azole of choice for Cryptococcal meningitis and mucocutaneous candidiasis?
Which fungal infection can high doses of fluconazole help obviate the need for intrathecal amphotericin B?
Which fungal infection can high doses of fluconazole help obviate the need for intrathecal amphotericin B?
What is a distinguishing factor of fluconazole's effect on hepatic microsomal enzymes compared to other azoles?
What is a distinguishing factor of fluconazole's effect on hepatic microsomal enzymes compared to other azoles?
Which of the following statements about voriconazole is correct?
Which of the following statements about voriconazole is correct?
Which of the following is NOT a potential toxicity associated with voriconazole?
Which of the following is NOT a potential toxicity associated with voriconazole?
Which of the following statements about itraconazole is correct?
Which of the following statements about itraconazole is correct?
Which of the following statements about posaconazole is correct?
Which of the following statements about posaconazole is correct?
Which of the following statements about isavuconazole is correct?
Which of the following statements about isavuconazole is correct?
Which of the following statements about ketoconazole is correct?
Which of the following statements about ketoconazole is correct?
Which of the following is a characteristic of echinocandins?
Which of the following is a characteristic of echinocandins?
Which of the following is a potential toxicity associated with caspofungin?
Which of the following is a potential toxicity associated with caspofungin?
What is a distinguishing characteristic of micafungin compared to caspofungin?
What is a distinguishing characteristic of micafungin compared to caspofungin?
Which echinocandin has the longest half-life?
Which echinocandin has the longest half-life?
Which echinocandin is used for the treatment of esophageal and invasive candidiasis?
Which echinocandin is used for the treatment of esophageal and invasive candidiasis?
Which of the following statements about echinocandins is correct?
Which of the following statements about echinocandins is correct?
Which antifungal drug is keratophilic and requires administration for 2-6 weeks for skin and hair infections?
Which antifungal drug is keratophilic and requires administration for 2-6 weeks for skin and hair infections?
Which toxicity is specifically associated with griseofulvin use?
Which toxicity is specifically associated with griseofulvin use?
Why must griseofulvin be administered for months in the case of nail infections?
Why must griseofulvin be administered for months in the case of nail infections?
Which drug has an unclear mechanism of action at the cellular level but binds to newly forming skin?
Which drug has an unclear mechanism of action at the cellular level but binds to newly forming skin?
What is the mechanism of action of griseofulvin?
What is the mechanism of action of griseofulvin?
Which of the following statements is true regarding the absorption of griseofulvin?
Which of the following statements is true regarding the absorption of griseofulvin?
What is the mechanism of action of terbinafine at the cellular level?
What is the mechanism of action of terbinafine at the cellular level?
Which of the following statements about terbinafine is true?
Which of the following statements about terbinafine is true?
How does terbinafine exert its antifungal effect?
How does terbinafine exert its antifungal effect?
What is a potential adverse effect associated with terbinafine?
What is a potential adverse effect associated with terbinafine?
What is the mechanism of action of nystatin?
What is the mechanism of action of nystatin?
Which of the following is an advantage of nystatin?
Which of the following is an advantage of nystatin?
Which of the following is a common indication for nystatin?
Which of the following is a common indication for nystatin?
Which of the following statements about clotrimazole and miconazole is correct?
Which of the following statements about clotrimazole and miconazole is correct?
What is a common use of topical ketoconazole?
What is a common use of topical ketoconazole?
Which of the following statements about the absorption of topical antifungals is correct?
Which of the following statements about the absorption of topical antifungals is correct?
What is the most common indication for the use of nystatin?
What is the most common indication for the use of nystatin?
Which antifungal agent is used as a pleasant-tasting alternative to nystatin for the treatment of oral thrush?
Which antifungal agent is used as a pleasant-tasting alternative to nystatin for the treatment of oral thrush?
Which topical antifungal is effective against tinea cruris and tinea corporis?
Which topical antifungal is effective against tinea cruris and tinea corporis?
Which topical antifungal is specifically useful for dermatophytic infections?
Which topical antifungal is specifically useful for dermatophytic infections?
Which topical antifungal is most commonly used for intertriginous candidal infections?
Which topical antifungal is most commonly used for intertriginous candidal infections?
