Podcast
Questions and Answers
What is the primary advantage of benzodiazepines over other anxiolytics?
What is the primary advantage of benzodiazepines over other anxiolytics?
What type of receptor does Buspirone act on?
What type of receptor does Buspirone act on?
What is the characteristic of the lethal dose of benzodiazepines compared to their therapeutic dose?
What is the characteristic of the lethal dose of benzodiazepines compared to their therapeutic dose?
What is the classification of Zolpidem?
What is the classification of Zolpidem?
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What is the characteristic that makes benzodiazepines the most widely used anxiolytics?
What is the characteristic that makes benzodiazepines the most widely used anxiolytics?
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What is the effect of binding of benzodiazepines to their specific site on GABAA receptor?
What is the effect of binding of benzodiazepines to their specific site on GABAA receptor?
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What is the difference in the mechanism of action between benzodiazepines and barbiturates?
What is the difference in the mechanism of action between benzodiazepines and barbiturates?
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What is the result of increased opening of the associated Cl-channel?
What is the result of increased opening of the associated Cl-channel?
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What is the effect of benzodiazepines on GABA binding?
What is the effect of benzodiazepines on GABA binding?
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What is the outcome of increased hyperpolarization of the neuron?
What is the outcome of increased hyperpolarization of the neuron?
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Study Notes
Classification of Anxiolytics
- Anxiolytics can be classified into three categories: barbiturates, benzodiazepines, and novel drugs.
Barbiturates
- Barbiturates are a class of anxiolytics.
Benzodiazepines
- Benzodiazepines are the most widely used anxiolytics due to their effectiveness and safety profile.
- The lethal dose of benzodiazepines is over 1000 times greater than the therapeutic dose, making them a relatively safe option.
Novel Drugs
- Novel drugs include buspirone, which is a 5HT1A receptor agonist.
- Zolpidem is a selective BZ1 agonist and is also classified as a novel drug.
Mechanism of Action of Benzodiazepines (BZs) and Barbiturates
- Binding of BZs to their specific site on the GABAA receptor increases the affinity of GABA to its binding site.
- This results in the opening of the associated Cl- channel.
- Opening of the Cl- channel leads to more hyperpolarization.
- Hyperpolarization further inhibits neuronal excitability.
Difference in Mechanism of Action between BZs and Barbiturates
- Barbiturates have the same mechanism of action as BZs.
- However, barbiturates bind to a different site on the GABAA receptor.
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Description
This quiz covers the classification of anxiolytics, including barbiturates, benzodiazepines, and novel drugs such as buspirone and zolpidem.
