Cardio Lecture 1

Which of the following is a type of antithrombotic drug?

What is the function of heparin within the secretory granules of mast cells?

Which factor is required for an activated coagulation factor to cleave and activate the next coagulation factor?

Which natural anticoagulant molecule enhances the activity of antithrombin by about 1000-fold?

Which of the following is NOT one of the principal players of the clotting factor cascade?

What is the difference between the Intrinsic and Extrinsic pathways?

Which anticoagulant agent cannot be reversed with a reversal agent?

Which of the following is NOT a direct factor Xa inhibitor?

Which of the following is a unique characteristic of Rivaroxaban?

What is the function of Andexanet alfa?

Which of the following is a method used in the manufacturing process of low molecular weight heparins (LMWHs)?

Which of the following is a major advantage of LMWHs over unfractionated heparin (UFH)?

Which of the following is true about the molecular weight (MW) of LMWHs and UFH?

Which of the following can cause heparin-induced thrombocytopenia (HIT)?

Which of the following drugs blocks the gama-carboxylation of glutamate residues in prothrombin and factors II, VII, IX, X and the endogenous anticoagulant protein C?

What is the mechanism of action of warfarin?

Which of the following drugs can cause prolonged resistance to warfarin when taken in high doses?

Which of the following drugs directly inhibits thrombin?

Which of the following is true about heparin chains?

What is the significance of the antithrombin-binding pentasaccharide in heparin?

What is the main mechanism of action of low molecular weight heparin (LMWH)?

What is the average molecular weight of low molecular weight heparin (LMWH)?

Which of the following is a direct inhibitor of thrombin that binds both the catalytic site and the anion binding exosite of circulating and clot-bound thrombin?

Which of the following is a direct oral anticoagulant that is a factor Xa inhibitor?

Which of the following is a unique formulation of Dabigatran?

Which drug is used as a reversal agent for Dabigatran to reverse/block its anticoagulant activity?

Which of the following is a direct oral anticoagulant that is a factor Xa inhibitor?

What is the average molecular weight of low molecular weight heparin (LMWH)?

What is the main mechanism of action of warfarin?

Which of the following is a major advantage of low molecular weight heparins (LMWHs) over unfractionated heparin (UFH)?

Which of the following is NOT a consequence of LMWH structural variability?

What is the molecular weight range of unfractionated heparin (UFH)?

What is the ratio of Anti-Xa to Anti-IIa (thrombin) activity for fondaparinux (synthetic pentasaccharide)?

Which of the following is NOT a type of antithrombotic drug in clinical use?

What is the function of antithrombin in the coagulation cascade?

Which factor is required for an activated coagulation factor to cleave and activate the next coagulation factor?

What is the mechanism of action of heparin within the secretory granules of mast cells?

Which of the following is a characteristic of low molecular weight heparin (LMWH)?

What is the average molecular weight of unfractionated heparin (UFH)?

Which of the following is a method used in the manufacturing process of low molecular weight heparins (LMWHs)?

What is the main mechanism of action of unfractionated heparin (UFH)?

Which of the following is a direct inhibitor of thrombin that binds both the catalytic site and the anion binding exosite of circulating and clot-bound thrombin?

Which of the following is an orally active direct thrombin inhibitor?

Which of the following is a unique formulation of Dabigatran?

Which of the following is a major P-gp drug-drug interaction (DDI) with Dabigatran?

Which of the following is a direct factor Xa inhibitor that competitively binds and blocks the active site of FXa, but does not inhibit thrombin and therefore has no direct effects on platelets?

Which of the following is a reversal agent for direct FXa inhibitors, designed to bind and sequester the factor Xa inhibitors so that they can no longer bind and inhibit endogenous factor Xa?

Which of the following direct FXa inhibitors has a unique absorption and PK profile, with a mandatory food requirement for higher doses due to its lipophilic structure and limited aqueous solubility?

Which of the following is true about the mechanism of action of Vitamin K antagonists such as warfarin?

Which of the following drugs can promote bleeding by displacing warfarin from albumin?

Which of the following drugs can inhibit the degradation of warfarin and lead to an increase in its effect?

Which of the following drugs can decrease the synthesis of clotting factors and result in a decrease in warfarin's anticoagulant effect?