Circadian Rhythms and Tissue Transplants

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Questions and Answers

What is the likely reason for the increase in sympathetic nervous system activation and inflammation?

  • Sleep deprivation (correct)
  • Excess production of serotonin
  • Decrease in cortisol
  • High melatonin levels

Which proteins are involved in the cellular basis of circadian rhythms?

  • Amylase, pepsin, and lipase
  • Insulin, glucagon, and leptin
  • Hemoglobin, myoglobin, and collagen
  • Per, tim, and Clock (correct)

Which gland produces and releases more melatonin as a response to decreased SCN activity?

  • Parathyroid gland
  • Thyroid gland
  • Pineal gland (correct)
  • Pituitary gland

What helps initiate sleep through the suprachiasmatic nucleus (SCN)?

<p>Elevated melatonin levels (A)</p> Signup and view all the answers

Which cells provide light information to the SCN?

<p>Intrinsically photosensitive retinal ganglion cells (ipRGC) (C)</p> Signup and view all the answers

Which structure can generate and maintain circadian rhythms independently of input from other structures?

<p>Suprachiasmatic nucleus (SCN) (C)</p> Signup and view all the answers

What is the main function of the SCN in regulating circadian rhythms?

<p>Producing specific proteins that interact to create a self-sustaining feedback loop (B)</p> Signup and view all the answers

In Yamazaki et al.’s rat study, how did the adjustment time of liver tissues compare to that of the lung and muscle tissues following a phase shift?

<p>Liver tissues required more cycles than lung and muscle tissues (B)</p> Signup and view all the answers

Which proteins inhibit the production of Clock, a key protein involved in circadian rhythms?

<p>Per and tim proteins (C)</p> Signup and view all the answers

What is the role of CLOCK protein in the cellular basis of circadian rhythms?

<p>Disinhibiting the production of per and tim proteins (B)</p> Signup and view all the answers

What mechanism does the SCN use to regulate the release of melatonin from the pineal gland?

<p>Sympathetic nervous system (D)</p> Signup and view all the answers

What differentiates the adjustment speed of peripheral clocks from that of the SCN when faced with phase shifts?

<p>SCN requires more cycles to adjust than peripheral clocks (B)</p> Signup and view all the answers

What is the primary function of the Cholinergic mesopontine nuclei?

<p>Modulating the amount of sensory input the cortex receives (A)</p> Signup and view all the answers

Which neurotransmitter is predominantly associated with Locus coeruleus?

<p>Norepinephrine (C)</p> Signup and view all the answers

What effect does continued activation by input from the raphe nuclei have on circuits promoting waking?

<p>It inhibits them (C)</p> Signup and view all the answers

What happens in the thalamus when there are no inputs promoting waking?

<p>Neurons synchronize activity in the cortex (A)</p> Signup and view all the answers

What is a direct effect of electrical stimulation of 'NREM-on cells' in the POA?

<p>Immediate NREM sleep (B)</p> Signup and view all the answers

How do lesions of 'NREM-on cells' in the POA affect sleep?

<p>Result in insomnia (B)</p> Signup and view all the answers

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