Chylomicron Synthesis and Assembly Quiz

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Which apolipoprotein is primarily found in chylomicrons?

Apolipoprotein E (apoE)

Apolipoprotein B-100 (apoB-100)

Apolipoprotein B-48 (apoB-48) (correct)

Apolipoprotein A-I (apoA-I)

Where are chylomicrons synthesized?

Liver

Stomach

Intestine (correct)

Pancreas

What happens to dietary lipids after a meal?

They are absorbed in the liver

They are absorbed in the small intestine (correct)

They are excreted

They are stored in the pancreas

What is the major apolipoprotein in VLDL?

Apolipoprotein B-100 (apoB-100) Signup and view all the answers

Where are VLDL particles synthesized?

Liver Signup and view all the answers

What happens to chylomicrons after they are secreted into the lymphatic system?

They enter the bloodstream via the thoracic duct Signup and view all the answers

What enzyme hydrolyzes triglycerides in chylomicrons?

Lipoprotein lipase (LPL) Signup and view all the answers

What happens to chylomicrons as they lose triglycerides?

They become smaller and form chylomicron remnants Signup and view all the answers

What interacts with hepatic receptors to clear chylomicron remnants from the circulation?

Apolipoprotein E (apoE) Signup and view all the answers

What transforms VLDL into intermediate density lipoprotein (IDL)?

Lipoprotein lipase (LPL) Signup and view all the answers

Which lipoprotein primarily contains apoB-100 and is formed from the delipidation of IDL particles?

LDL Signup and view all the answers

What is the role of apoB-100 in the cellular uptake of LDL particles?

It acts as a ligand for binding to LDL receptors Signup and view all the answers

How are LDL particles internalized into cells?

Through receptor-mediated endocytosis Signup and view all the answers

What is the primary apolipoprotein associated with HDL particles?

apoA-I Signup and view all the answers

How does HDL promote cholesterol removal from tissues?

Through the action of ATP-binding cassette transporter A1 (ABCA1) Signup and view all the answers

What is the enzyme responsible for esterifying free cholesterol into cholesteryl esters in HDL particles?

LCAT Signup and view all the answers

How can HDL cholesterol be transferred to other lipoproteins, such as VLDL or LDL?

Through the action of cholesterol ester transfer protein (CETP) Signup and view all the answers

What happens to LDL particles once they are inside the cells?

They are subjected to lysosomal degradation Signup and view all the answers

What is the relationship between cellular cholesterol levels and LDL receptor expression?

High cellular cholesterol levels downregulate LDL receptor expression Signup and view all the answers

Where are HDL particles synthesized?

Liver and intestine Signup and view all the answers