Chylomicron Synthesis and Assembly Quiz

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Questions and Answers

Which apolipoprotein is primarily found in chylomicrons?

  • Apolipoprotein E (apoE)
  • Apolipoprotein B-100 (apoB-100)
  • Apolipoprotein B-48 (apoB-48) (correct)
  • Apolipoprotein A-I (apoA-I)

Where are chylomicrons synthesized?

  • Liver
  • Stomach
  • Intestine (correct)
  • Pancreas

What happens to dietary lipids after a meal?

  • They are absorbed in the liver
  • They are absorbed in the small intestine (correct)
  • They are excreted
  • They are stored in the pancreas

What is the major apolipoprotein in VLDL?

<p>Apolipoprotein B-100 (apoB-100) (D)</p> Signup and view all the answers

Where are VLDL particles synthesized?

<p>Liver (C)</p> Signup and view all the answers

What happens to chylomicrons after they are secreted into the lymphatic system?

<p>They enter the bloodstream via the thoracic duct (C)</p> Signup and view all the answers

What enzyme hydrolyzes triglycerides in chylomicrons?

<p>Lipoprotein lipase (LPL) (B)</p> Signup and view all the answers

What happens to chylomicrons as they lose triglycerides?

<p>They become smaller and form chylomicron remnants (D)</p> Signup and view all the answers

What interacts with hepatic receptors to clear chylomicron remnants from the circulation?

<p>Apolipoprotein E (apoE) (D)</p> Signup and view all the answers

What transforms VLDL into intermediate density lipoprotein (IDL)?

<p>Lipoprotein lipase (LPL) (B)</p> Signup and view all the answers

Which lipoprotein primarily contains apoB-100 and is formed from the delipidation of IDL particles?

<p>LDL (D)</p> Signup and view all the answers

What is the role of apoB-100 in the cellular uptake of LDL particles?

<p>It acts as a ligand for binding to LDL receptors (C)</p> Signup and view all the answers

How are LDL particles internalized into cells?

<p>Through receptor-mediated endocytosis (C)</p> Signup and view all the answers

What is the primary apolipoprotein associated with HDL particles?

<p>apoA-I (A)</p> Signup and view all the answers

How does HDL promote cholesterol removal from tissues?

<p>Through the action of ATP-binding cassette transporter A1 (ABCA1) (C)</p> Signup and view all the answers

What is the enzyme responsible for esterifying free cholesterol into cholesteryl esters in HDL particles?

<p>LCAT (A)</p> Signup and view all the answers

How can HDL cholesterol be transferred to other lipoproteins, such as VLDL or LDL?

<p>Through the action of cholesterol ester transfer protein (CETP) (A)</p> Signup and view all the answers

What happens to LDL particles once they are inside the cells?

<p>They are subjected to lysosomal degradation (B)</p> Signup and view all the answers

What is the relationship between cellular cholesterol levels and LDL receptor expression?

<p>High cellular cholesterol levels downregulate LDL receptor expression (C)</p> Signup and view all the answers

Where are HDL particles synthesized?

<p>Liver and intestine (B)</p> Signup and view all the answers

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