20 Questions
Which apolipoprotein is primarily found in chylomicrons?
Apolipoprotein B-48 (apoB-48)
Where are chylomicrons synthesized?
Intestine
What happens to dietary lipids after a meal?
They are absorbed in the small intestine
What is the major apolipoprotein in VLDL?
Apolipoprotein B-100 (apoB-100)
Where are VLDL particles synthesized?
Liver
What happens to chylomicrons after they are secreted into the lymphatic system?
They enter the bloodstream via the thoracic duct
What enzyme hydrolyzes triglycerides in chylomicrons?
Lipoprotein lipase (LPL)
What happens to chylomicrons as they lose triglycerides?
They become smaller and form chylomicron remnants
What interacts with hepatic receptors to clear chylomicron remnants from the circulation?
Apolipoprotein E (apoE)
What transforms VLDL into intermediate density lipoprotein (IDL)?
Lipoprotein lipase (LPL)
Which lipoprotein primarily contains apoB-100 and is formed from the delipidation of IDL particles?
LDL
What is the role of apoB-100 in the cellular uptake of LDL particles?
It acts as a ligand for binding to LDL receptors
How are LDL particles internalized into cells?
Through receptor-mediated endocytosis
What is the primary apolipoprotein associated with HDL particles?
apoA-I
How does HDL promote cholesterol removal from tissues?
Through the action of ATP-binding cassette transporter A1 (ABCA1)
What is the enzyme responsible for esterifying free cholesterol into cholesteryl esters in HDL particles?
LCAT
How can HDL cholesterol be transferred to other lipoproteins, such as VLDL or LDL?
Through the action of cholesterol ester transfer protein (CETP)
What happens to LDL particles once they are inside the cells?
They are subjected to lysosomal degradation
What is the relationship between cellular cholesterol levels and LDL receptor expression?
High cellular cholesterol levels downregulate LDL receptor expression
Where are HDL particles synthesized?
Liver and intestine
Test your knowledge on the synthesis and assembly of chylomicrons in the intestine. Learn about the role of apolipoprotein B-48 and the absorption of dietary lipids.
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