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Questions and Answers
Which of the following is a characteristic of Chronic Myeloproliferative Disorders (MPD)?
Which of the following is a characteristic of Chronic Myeloproliferative Disorders (MPD)?
- Absence of splenomegaly in 60-100% of patients
- Predominantly affects young individuals
- Rapid, symptomatic onset
- Insidious, asymptomatic onset (correct)
What is the origin of Myeloproliferative Disorders (MPD)?
What is the origin of Myeloproliferative Disorders (MPD)?
- Neoplastic transformation of a single multipotential stem cell (correct)
- Proliferation of fibroblasts in the bone marrow
- Abnormal differentiation of lymphoid cell lines
- Mutation in the BCR-ABL gene
What percentage of patients with Chronic MPD experience splenomegaly?
What percentage of patients with Chronic MPD experience splenomegaly?
- 30-60%
- 0%
- 10-30%
- 60-100% (correct)
What is the main cause of bleeding and thrombosis in Chronic MPD?
What is the main cause of bleeding and thrombosis in Chronic MPD?
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Which type of leukemia is characterized by excessive proliferation of eosinophils?
Which type of leukemia is characterized by excessive proliferation of eosinophils?
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Study Notes
Myeloproliferative Disorders (MPD)
- MPD are a group of acquired, malignant disorders with common clinical and hematological features.
- Caused by excessive proliferation of both hematopoietic cells and fibroblasts in the bone marrow (BM).
- Characterized by a hypercellular BM with increased quantities of one or more cellular lineages.
Classification of MPD
- Distinguished by the predominant cell type involved:
- High granulocytes in CML
- High RBC in PV
- High Plt in ET
- High fibrosis in IMF
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