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Chronic Myeloproliferative Disorders Investigation

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Chronic Myeloproliferative Disorders Investigation

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Questions and Answers

Which of the following is a characteristic of Chronic Myeloproliferative Disorders (MPD)?

Absence of splenomegaly in 60-100% of patients

Predominantly affects young individuals

Rapid, symptomatic onset

Insidious, asymptomatic onset (correct)

What is the origin of Myeloproliferative Disorders (MPD)?

Neoplastic transformation of a single multipotential stem cell (correct)

Proliferation of fibroblasts in the bone marrow

Abnormal differentiation of lymphoid cell lines

Mutation in the BCR-ABL gene

What percentage of patients with Chronic MPD experience splenomegaly?

30-60%

10-30%

60-100% (correct)

What is the main cause of bleeding and thrombosis in Chronic MPD?

<p>Platelet abnormalities</p> Signup and view all the answers

Which type of leukemia is characterized by excessive proliferation of eosinophils?

<p>Chronic eosinophilic leukemia (CEL)</p> Signup and view all the answers

Study Notes

Myeloproliferative Disorders (MPD)

MPD are a group of acquired, malignant disorders with common clinical and hematological features.
Caused by excessive proliferation of both hematopoietic cells and fibroblasts in the bone marrow (BM).
Characterized by a hypercellular BM with increased quantities of one or more cellular lineages.

Classification of MPD

Distinguished by the predominant cell type involved:
- High granulocytes in CML
- High RBC in PV
- High Plt in ET
- High fibrosis in IMF

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Description

This quiz covers the investigation of Chronic Myeloproliferative Disorders including the definition, classification, and lab features of myeloproliferative disorders such as chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis.