5 Questions
Which of the following is a characteristic of Chronic Myeloproliferative Disorders (MPD)?
Insidious, asymptomatic onset
What is the origin of Myeloproliferative Disorders (MPD)?
Neoplastic transformation of a single multipotential stem cell
What percentage of patients with Chronic MPD experience splenomegaly?
60-100%
What is the main cause of bleeding and thrombosis in Chronic MPD?
Platelet abnormalities
Which type of leukemia is characterized by excessive proliferation of eosinophils?
Chronic eosinophilic leukemia (CEL)
Study Notes
Myeloproliferative Disorders (MPD)
- MPD are a group of acquired, malignant disorders with common clinical and hematological features.
- Caused by excessive proliferation of both hematopoietic cells and fibroblasts in the bone marrow (BM).
- Characterized by a hypercellular BM with increased quantities of one or more cellular lineages.
Classification of MPD
- Distinguished by the predominant cell type involved:
- High granulocytes in CML
- High RBC in PV
- High Plt in ET
- High fibrosis in IMF
This quiz covers the investigation of Chronic Myeloproliferative Disorders including the definition, classification, and lab features of myeloproliferative disorders such as chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
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