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Chronic Interstitial Lung Diseases Overview

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Chronic Interstitial Lung Diseases Overview

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Questions and Answers

Which best describes the hallmark feature of chronic interstitial lung diseases?

Reduced effort of breathing

Damage to the alveolar epithelium

Increased compliance due to stiff lungs

Reduced compliance requiring more pressure to expand the lungs (correct)

What is the radiologic and histologic pattern of fibrosis referred to in idiopathic pulmonary fibrosis?

Non-specific interstitial pneumonia

Cryptogenic organizing pneumonia

Usual interstitial pneumonia (correct)

Cryptogenic fibrosing alveolitis

Which cell type response is induced in idiopathic pulmonary fibrosis lesions?

TH17 type T cell response

TH3 type T cell response

TH1 type T cell response

TH2 type T cell response (correct)

What is the pathogenesis of idiopathic pulmonary fibrosis believed to be caused by?

Repeated cycles of epithelial activation/injury Signup and view all the answers

What is a characteristic feature of advanced cases of idiopathic pulmonary fibrosis?

Severe hypoxemia and cyanosis Signup and view all the answers

Which type of cells may play a dominant role in the pathogenesis of lung fibrosis according to recent data?

Macrophages Signup and view all the answers

What substance is released from injured type I pneumocytes and induces transformation of fibroblasts into myofibroblasts?

TGF-β1 Signup and view all the answers

In familial IPF, some patients have mutations that shorten what?

Telomeres leading to rapid senescence and apoptosis of pneumocytes Signup and view all the answers

What is the characteristic radiographic finding in chest radiographs of patients with chronic interstitial lung diseases?

Diffuse infiltration by nodules, irregular lines, or "ground glass shadows" Signup and view all the answers

What is the most peripheral component involved in chronic interstitial lung diseases?

Pulmonary alveoli Signup and view all the answers