Chronic Interstitial Lung Diseases Overview
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Questions and Answers

Which best describes the hallmark feature of chronic interstitial lung diseases?

  • Reduced effort of breathing
  • Damage to the alveolar epithelium
  • Increased compliance due to stiff lungs
  • Reduced compliance requiring more pressure to expand the lungs (correct)

    • What is the radiologic and histologic pattern of fibrosis referred to in idiopathic pulmonary fibrosis?

  • Non-specific interstitial pneumonia
  • Cryptogenic organizing pneumonia
  • Usual interstitial pneumonia (correct)
  • Cryptogenic fibrosing alveolitis

    • Which cell type response is induced in idiopathic pulmonary fibrosis lesions?

  • TH17 type T cell response
  • TH3 type T cell response
  • TH1 type T cell response
  • TH2 type T cell response (correct)

    • What is the pathogenesis of idiopathic pulmonary fibrosis believed to be caused by?

    <p>Repeated cycles of epithelial activation/injury</p> Signup and view all the answers

    What is a characteristic feature of advanced cases of idiopathic pulmonary fibrosis?

    <p>Severe hypoxemia and cyanosis</p> Signup and view all the answers

    Which type of cells may play a dominant role in the pathogenesis of lung fibrosis according to recent data?

    <p>Macrophages</p> Signup and view all the answers

    What substance is released from injured type I pneumocytes and induces transformation of fibroblasts into myofibroblasts?

    <p>TGF-β1</p> Signup and view all the answers

    In familial IPF, some patients have mutations that shorten what?

    <p>Telomeres leading to rapid senescence and apoptosis of pneumocytes</p> Signup and view all the answers

    What is the characteristic radiographic finding in chest radiographs of patients with chronic interstitial lung diseases?

    <p>Diffuse infiltration by nodules, irregular lines, or &quot;ground glass shadows&quot;</p> Signup and view all the answers

    What is the most peripheral component involved in chronic interstitial lung diseases?

    <p>Pulmonary alveoli</p> Signup and view all the answers

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