Podcast
Questions and Answers
Which type of granulomas primarily indicates an infection caused by bacteria?
Which type of granulomas primarily indicates an infection caused by bacteria?
Which type of inflammation is characterized by the dominance of macrophages?
Which type of inflammation is characterized by the dominance of macrophages?
What type of granulomas are typically associated with foreign materials or substances?
What type of granulomas are typically associated with foreign materials or substances?
Which of the following cells is NOT typically found in chronic inflammation?
Which of the following cells is NOT typically found in chronic inflammation?
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Which of the following granulomas is classified under 'granulomas of unknown etiology'?
Which of the following granulomas is classified under 'granulomas of unknown etiology'?
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Which cell type is commonly present at the site of necrosis in tissue inflammation?
Which cell type is commonly present at the site of necrosis in tissue inflammation?
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Which type of granuloma is often necrotizing in nature?
Which type of granuloma is often necrotizing in nature?
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What is the primary type of cell that forms giant cells in chronic inflammation?
What is the primary type of cell that forms giant cells in chronic inflammation?
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What best describes chronic inflammation?
What best describes chronic inflammation?
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Which of the following can initiate chronic inflammation?
Which of the following can initiate chronic inflammation?
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What is a key feature of chronic inflammation?
What is a key feature of chronic inflammation?
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Which of these conditions is NOT a cause of chronic inflammation?
Which of these conditions is NOT a cause of chronic inflammation?
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Which process is often involved in the healing attempts during chronic inflammation?
Which process is often involved in the healing attempts during chronic inflammation?
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What is a consequence of chronic inflammation?
What is a consequence of chronic inflammation?
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What role do cytokines play in chronic inflammation?
What role do cytokines play in chronic inflammation?
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Which of the following statements about chronic inflammation is accurate?
Which of the following statements about chronic inflammation is accurate?
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What type of cells predominantly infiltrate the site of chronic inflammation?
What type of cells predominantly infiltrate the site of chronic inflammation?
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What is a primary characteristic that differentiates chronic inflammation from acute inflammation?
What is a primary characteristic that differentiates chronic inflammation from acute inflammation?
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What type of chronic inflammation typically follows an episode of acute inflammation?
What type of chronic inflammation typically follows an episode of acute inflammation?
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Which feature is specifically associated with granulomatous inflammation?
Which feature is specifically associated with granulomatous inflammation?
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What is usually found surrounded by fibrosis in older granulomas?
What is usually found surrounded by fibrosis in older granulomas?
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What is NOT a characteristic feature of chronic inflammation?
What is NOT a characteristic feature of chronic inflammation?
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Which cell type is most prominently found in a granuloma?
Which cell type is most prominently found in a granuloma?
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Chronic inflammation usually results in which of the following?
Chronic inflammation usually results in which of the following?
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What differentiates chronic specific inflammation from chronic non-specific inflammation?
What differentiates chronic specific inflammation from chronic non-specific inflammation?
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What type of inflammatory response includes a distinct pattern with central necrosis?
What type of inflammatory response includes a distinct pattern with central necrosis?
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What is typically true regarding the fluid exudate in chronic inflammation?
What is typically true regarding the fluid exudate in chronic inflammation?
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Study Notes
Chronic Inflammation
- Definition:
- Inflammation of prolonged duration ("weeks to years").
- In which inflammation, tissue destruction & healing occurs in the same time in varying combinations.
- The chronic inflammatory reactions may promote tumor development.
Causes of Chronic Inflammation
- May follow acute inflammation due to failure of immunity.
- May start chronic by gradual onset due to:
- Infection with resistant organisms that are difficult to eradicate, such as TB.
- Prolonged exposure to potentially toxic agents, e.g. Silicosis, atherosclerosis
- Development of hypersensitivity diseases/autoimmunity
Morphologic Features
- Infiltration with mononuclear cells: Chronic inflammation is mediated by cytokines → amplify and prolong the inflammatory reaction.
- Tissue destruction: induced by the persistent offending agent or by the inflammatory cells.
- Attempts at healing: replacement of damaged tissue, by proliferation of small blood vessels and fibrosis.
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Description
Explore the complex nature of chronic inflammation, including its definition, causes, and morphological features. This quiz provides insights into how chronic inflammation can lead to tissue destruction and its role in various diseases, including cancer. Test your understanding of the mechanisms involved in this prolonged inflammatory state.
