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Chromosome Segregation Errors Quiz

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Questions and Answers

What is a major consequence of segregation defects during cell division?

Improved gene expression in the progeny cells

Change in the relative dosage of products from genes located on the missegregated chromosomes (correct)

Increased number of chromosomes in the progeny cells

Enhanced stability of the organism

What can abnormal expression of transcriptional regulators impact?

Genes on the properly segregated chromosomes (correct)

Cell division frequency

Chromosome content in the progeny cells

Mitotic spindle formation

What are the consequences of perturbations in gene expression dependent on?

The specific chromosomes affected and the interplay of the aneuploid phenotype with the environment (correct)

The number of cell divisions

The type of cell membrane

The size of the cells

What is the impact of novel chromosome distributions on the health and survival of the organism?

Most often detrimental Signup and view all the answers

What do mistakes during cell division frequently generate?

Changes in chromosome content Signup and view all the answers

What is the impact of mitotic errors on tumor responsiveness to immunotherapy?

They can impact tumor responsiveness to immunotherapy Signup and view all the answers

What is the primary role of mitosis in ensuring genomic stability?

To ensure genomic stability Signup and view all the answers

How do mitotic errors shape cancer genomes?

By driving numerical and structural alterations in chromosomes Signup and view all the answers

What vulnerabilities are exposed by cell division errors?

Vulnerabilities that can be exploited therapeutically Signup and view all the answers

What do new findings suggest about chromosome missegregation?

It can produce a proinflammatory environment Signup and view all the answers