Cholinergic Agonists Overview Unit 4.3

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Questions and Answers

What does the parasympathetic nervous system do?

  • Controls voluntary movements
  • Regulates body temperature
  • Slows down the body's processes and promotes rest (correct)
  • Stimulate the body's fight-or-flight response

Which of the following is NOT a type of receptor that cholinergic agonists affect?

  • Dopaminergic receptors (correct)
  • Muscarinic receptors
  • Nicotinic receptors
  • Adrenergic receptors (correct)

Cholinergic agonists constrict the pupils of the eye.

True (A)

Which of the following is an effect of cholinergic agonists on the lungs?

<p>Constricts bronchioles, increases secretions (B)</p> Signup and view all the answers

What is the primary use of Bethanechol Chloride?

<p>Treats urinary retention</p> Signup and view all the answers

Which of the following is a side effect of Bethanechol Chloride?

<p>Blurred vision (C)</p> Signup and view all the answers

Which of the following is NOT a recommended nursing intervention for patients taking Bethanechol Chloride?

<p>Administer the medication with meals (B)</p> Signup and view all the answers

Pilocarpine is a cholinergic agonist used to treat which condition?

<p>Glaucoma (B)</p> Signup and view all the answers

How does Pilocarpine decrease pressure in the eye?

<p>It constricts the pupil which opens the canal of Schlemm to promote drainage of the aqueous humor.</p> Signup and view all the answers

Flashcards

Cholinergic Agonists

Substances that mimic the effects of acetylcholine by stimulating cholinergic receptors, resulting in parasympathetic nervous system activation.

Muscarinic receptors

Cholinergic receptors that affect smooth muscles, heart rate, and other internal organs.

Nicotinic receptors

Cholinergic receptors that affect skeletal muscles.

Bethanechol Chloride

A cholinergic agonist used to treat urinary retention by stimulating bladder contraction.

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Cholinergic Agonist Effects (Eyes)

Pupil constriction, increased aqueous humor drainage.

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Cholinergic Agonist Effects (Lungs)

Bronchoconstriction, increased secretions.

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Cholinergic Agonist Effects (Heart)

Decreased heart rate and dilated blood vessels.

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Cholinergic Agonist Effects (GI)

Increased peristalsis and secretions.

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Cholinergic Agonist Effects (Bladder)

Increased contraction of the bladder.

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Bethanechol Chloride Side Effects

Blurred vision, increased secretions, orthostatic hypotension, bronchoconstriction, hypotension, and tachycardia.

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Bethanechol Chloride Assessment

Monitor vital signs, urine output, medical history, and medication intake to guide treatment.

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Bethanechol Chloride Interventions

Monitor vital signs and lung sounds and closely check GI/GU function. Record intake and output. Give medication 1 hr before or 2 hrs after meals.

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Bethanechol Chloride Overdose

Muscular weakness and increased salivation; treat with antagonist atropine.

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Pilocarpine

Cholinergic agonist used to decrease eye pressure, given as eye drops; used in glaucoma patients

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Study Notes

Cholinergic Agonists

  • Cholinergic agonists stimulate the parasympathetic nervous system, mimicking the neurotransmitter acetylcholine.
  • They affect muscarinic receptors, influencing smooth muscles and slowing heart rate.
  • They also impact nicotinic receptors, affecting skeletal muscles.

Effects of Cholinergic Agonists

  • Eye: constrict the pupil
  • Lungs: constrict bronchioles, increase secretions
  • Heart and Blood Vessels: decrease heart rate, dilate blood vessels
  • Gastrointestinal: increase peristalsis and secretions
  • Bladder: constrict the bladder
  • Salivary and Sweat Glands: increase secretions

Cholinergic Agonist - Bethanechol Chloride

  • Action: Stimulates cholinergic receptors, causing bladder contraction.
  • Other effects include increased GI secretions and peristalsis, increased bronchial secretions/bronchoconstriction, and pupil constriction.
  • Uses: Treat urinary retention.
  • Side Effects/Adverse Reactions: blurred vision, increased secretions (lungs, GI tract, sweat), orthostatic hypotension, bronchoconstriction, hypotension, tachycardia.

Assessment

  • Vital signs
  • Urine output
  • Medication/medical history

Interventions

  • Monitor vital signs (watch for decreased BP and pulse)
  • Monitor lung sounds
  • Monitor GI/GU status
  • Monitor and record intake/output
  • Administer 1 hour before or 2 hours after meals
  • Monitor for overdose (signs include muscle weakness, increased salivation)
  • Antagonist: Atropine

Teach Client

  • Monitor blood pressure and heart rate (report any changes)
  • Rise slowly from a lying position
  • Take medication on an empty stomach (one hour before or two hours after meals)
  • Report muscle weakness or increased salivation

Evaluations

  • Client able to empty bladder

Cholinergic Agonist - Pilocarpine

  • Action: Constricts the pupil, opening the canal of Schlemm to promote drainage of aqueous humor.
  • Uses: Decrease pressure in the eye in diseases such as glaucoma.
  • Administered as eye drops.

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