CHM102 Organic Chemistry Course - Spring 2025

• CHM102 is a basic organic chemistry course for the Spring semester of January 2025.
• The instructor for the course is Dr. Sugumar Venkataramani, with office hours in 5F10, AB2.
• Tutors for the course are Dr. Moitree Laskar, Dr. Pooja, and Dr. Tamanna.
• Lectures are held on Tuesdays from 12:00 to 1:00 pm in LH6, Wednesdays from 3:00 to 4:00 pm, and Fridays from 3:00 to 4:00 pm in LH5.

Schedule Highlights

• January 7: Lecture 1
• January 9: Last date of late registration
• January 10: Lecture 3
• January 14: Makar Sankranti
• January 15 Lecture 4
• February 4: Lecture 12.
• February 5 Lecture 13
• February 6, 7, and 8: First Mid-Semester Exams.
• February 8 CHM102 exam at 10 am
• Total lectures before I mid-semester exams: 13
• February 11 Lecture 14
• February 12 Lecture 15
• February 14 Lecture 16
• February 17 Lecture 5
• February 18 Lecture 17
• February 19 Lecture 6, Lecture 18
• February 21 Lecture 7, Lecture 19
• February 22: Mid-semester exams
• February 24 Lecture 8
• February 25 Lecture 9
• February 26 Lecture 20
• February 28 Lecture 21
• February 28 Lecture 30
• March 4 Lecture 23
• March 5 Lecture 24
• March 6, 7, and 8: Second Mid-Semester Exams.
• CHM102 exam March 8 at 10 am
• Total lectures between first and second mid-semester: 11
• March 11: Mid-term break
• March 12: Mid-term break
• March 14: Holi Mid-term break
• March 18 Lecture 25
• March 19 Lecture 26
• March 21 Lecture 27
• March 22 Lecture 39
• March 25 Lecture 28
• March 26 Lecture 29
• March 31 Idu'l Fitr, Lecture 11
• April 1 Lecture 31
• April 2 Lecture 32
• April 4 Lecture 33
• April 5: MS thesis open seminar/poster session
• April 8 Lecture 34
• April 9 Lecture 35
• April 11 Lecture 36
• April 15 Lecture 37
• April 16 Lecture 38
• April 18: Good Friday
• April 19: Lab Exams (Friday time-table for all courses)
• April 22 Lecture 39
• April 23 Lecture 40
• April 25: Lecture 41
• Total lectures after second mid-semester: 17
• April 25: End sem Exams (for premajors) (MS Thesis Final hard copy submission Deadline)
• April 28 - May 10: End-semester exams
• April 28: End sem Exam
• April 29: End sem Exam
• April 30: End sem Exam
• May 1 CHM102 exam at 2.30 pm
• May 1: End sem Exam
• May 2 End sem Exam
• May 3 End sem Exam
• May 4 End sem Exam
• May 5 End sem Exam
• May 6 End sem Exam
• May 7 End sem Exam
• May 8 End sem Exam
• May 9 End sem Exam
• May 10 End sem Exam
• Total lectures: 41

Grading Policy

• Two grading plans are available, Plan A and Plan B.
• Plan B is activated if attendance drops significantly.

Plan A:

• First Mid-semester Exam: 20%
• Second Mid-semester Exam: 20%
• End-semester Exam: 50%
• Assignments: 10%
• Surprise Quizzes/Attendance: 0%

Plan B:

• First Mid-semester Exam: 15%
• Second Mid-semester Exam: 15%
• End-semester Exam: 50%
• Assignments: 5%
• Surprise Quizzes/Attendance: 15%

Course Outline: Basic Organic Chemistry

• Course credits are Cr:3, Lc:2, Tt:1, Lb:0.
• Covers importance of organic molecules in life
• Details the nomenclature of organic compounds with diverse structures and functional groups
• Teaches concepts involving acidity, basicity, tautomerism, inductive, mesomeric, Nathan field, and steric effects
• Conformational analysis of acyclic (ethane, butane, substituted acyclic compounds) and cyclic (cyclohexane, cyclopentane) systems
• Discusses energies and conformational preferences of differently substituted cyclohexanes and related systems.
• Axial (atropisomerism) and planar (helical) chirality.
• Optical isomerism in biphenyls and allenes.
• Geometrical isomerism (E/Z), acylic and cyclic compounds.
• It Includes a description of syn/anti (erythro, threo), meso isomers, absolute and relative stereochemistry
• Includes R/S configuration assignment. Racemization, resolution, prostereoisomerism, stereotopicity and enantiomeric excess, d,l isomers, and racemate.

Reaction Types and Mechanisms

• Details substitution reactions: Nucleophilic substitution at carbon and its mechanism (including chirality generation)
• Notes Grignard types reagents and their addition to carbonyls.
• Addition reactions: Addition of X, HX, boranes, and hydroxylation to C=C systems and epoxidation of olefins
• Stereoaspects of the addition of X, HX, X2, boranes, and hydroxylation to C=C systems
• Cis- and trans-hydroxylation of cycloalkenes and related reactions.
• Covers elimination reactions leading to C=C bond formation and their mechanisms including named reactions (e.g., Hoffman and Saytzeff eliminations).
• Talks about selectivity in organic reactions: Chemoselectivity, regioselectivity, enantio- and stereo-selectivity (explanation with examples)
• Reactive intermediates: Carbenes, nitrenes, carbocations, carbanions, and radicals.
• Includes reactions involving reactive intermediates, rearrangement reactions and mechanisms
• Reviews a basic introduction to thermodynamic vs kinetic control, Hammond postulate (energy profile diagram).
• Includes aromaticity and anti-aromaticity: Hückel and Craig's rules, homo, hetero (furan, thiophene, and pyrrole) and non-benzenoid aromatic systems. Polyaromatic compounds.

Recommended Reading

• J. Clayden, N. Greeves, S. G. Warren, Organic Chemistry, 2nd Ed, Oxford University Press, Oxford (2012).
• R. T. Morrison, R. N. Boyd, S. Bhattacherjee, Organic Chemistry, Indian Edition, 6th Ed, Pearson Education, New Delhi (2007).
• E. V. Anslyn, D. A. Dougherty, Modern Physical Organic Chemistry, University Science Books, 2005.

Suggested Reading

• M. B. Smith, March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 8th Ed, John Wiley & Sons, New Jersey (2020).
• P. Sykes, A Guidebook to Mechanism in Organic Chemistry, Indian Edition, 7th Ed, Pearson Education, New Delhi (2010) (Dorling Kindersley (India) Pvt Ltd).

Importance of Organic Chemistry

• Highlights the diverse structures possible, including catenation, ring fusion, various hybridization, and bonding arrangements.
• It relates to fantasy world, light driven motion, isomerism
• Organic chemistry is relevant to nature's choice of molecules like nucleobases (Adenine, Guanine, Cytosine, Thymine, Uracil), carbohydrates (D-Glucose), and nucleic acids.
• Industrial applications are related to dyes and pigments through resonance, extended conjugation, and light absorption.

Industrial Relevance in Perfumes and Flavoring Agents

• Includes cis-Jasmone of jasmine perfume, (-)-cis Rose oxide of Rose oil
• Alkyl pyrazine from coffee & roasted meat, Corylone from Caramel, Vanillin