Organic Chemistry Chapter 18 Flashcards
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Questions and Answers

The compound CH3CH2NHCH3 is classified as a?

  • Primary amine
  • Tertiary amine
  • Quaternary amine
  • Secondary amine (correct)

    • The compound CH3CH2NH2 is classified as a?

  • Tertiary amine
  • Secondary amine
  • Quaternary amine
  • Primary amine (correct)

    • Which of the following compounds is an amine?

  • C6H5N
  • CH3OH
  • C2H5OH
  • (CH3CH2)2NH (correct)

    • What is the name of the compound HNCH3-benzene ring-Br?

    <p>N-methyl-3-bromoaniline</p> Signup and view all the answers

    Aminobenzene is properly known as?

    <p>Aniline</p> Signup and view all the answers

    What is the name of the compound CH3-NCH2CH3-CH3?

    <p>Ethyldimethylamine</p> Signup and view all the answers

    Name the compound CH3-NH-CH3.

    <p>Dimethyl amine</p> Signup and view all the answers

    Amines contain the element?

    <p>Nitrogen</p> Signup and view all the answers

    In what kind of amine is the nitrogen directly bonded to two carbon atoms?

    <p>Secondary</p> Signup and view all the answers

    When naming amines according to the IUPAC system, the -e in the corresponding alkane is replaced with?

    <p>-amine</p> Signup and view all the answers

    Aniline is a(n)?

    <p>Primary aromatic amine</p> Signup and view all the answers

    What prefix is used to show that a small alkyl group is attached to the nitrogen of aniline and not to the aromatic ring?

    <p>N-</p> Signup and view all the answers

    How many alkyl substituents does N-ethyl-N-methylaniline have?

    <p>Two</p> Signup and view all the answers

    Which of the following compounds CANNOT form hydrogen bonds with water?

    <p>CH3CH2CH3 (A), (CH3CH2)3N (C)</p> Signup and view all the answers

    What relation does the boiling point of an amine have to a similar hydrocarbon?

    <p>Higher</p> Signup and view all the answers

    Amines can form ____ bonds with other molecules.

    <p>Hydrogen</p> Signup and view all the answers

    What kind of amine can NOT form hydrogen bonds?

    <p>Tertiary</p> Signup and view all the answers

    Amines are?

    <p>Bronsted-Lowry bases</p> Signup and view all the answers

    The odor of an amine can be neutralized with?

    <p>Acids</p> Signup and view all the answers

    Choline is a quaternary ammonium compound with a ___ charge on the nitrogen.

    <p>Positive</p> Signup and view all the answers

    In what form are amine-containing drugs often administered?

    <p>Amine salt</p> Signup and view all the answers

    What kind of pharmacologic activity is found in the amines Procaine and Lidocaine?

    <p>Local anesthetic</p> Signup and view all the answers

    What are alkaloids?

    <p>Physiologically active nitrogen compounds derived from plants</p> Signup and view all the answers

    Identify the heterocyclic amine in the choices below.

    <p>Pyrrolidine</p> Signup and view all the answers

    Among the choices below, identify the heterocyclic amine found in DNA.

    <p>Purine</p> Signup and view all the answers

    Nicotine, coniine, quinine, atropine, and morphine are all examples of?

    <p>Alkaloids</p> Signup and view all the answers

    Procaine and Lidocaine were developed by modifying the structure of?

    <p>Cocaine</p> Signup and view all the answers

    Physiologically active nitrogen-containing compounds produced by plants are called?

    <p>Alkaloids</p> Signup and view all the answers

    Which of the following is NOT an alkaloid?

    <p>Diethylamine (D)</p> Signup and view all the answers

    What functional group is always found in alkaloids (such as caffeine, nicotine, and digitalis)?

    <p>Amine</p> Signup and view all the answers

    Cyclic compounds that contain a nitrogen atom are called?

    <p>Heterocyclic Compounds</p> Signup and view all the answers

    What is the major functional group in the following compound? O=CH3CNHCH3

    <p>Amide</p> Signup and view all the answers

    What is the name of this compound? O=CNHCH2CH3-Hexagon shape.

    <p>N-ethylbenzamide</p> Signup and view all the answers

    One name for this compound is O=CH3CH2-C-NH-CH2CH3.

    <p>N-ethylpropanamide</p> Signup and view all the answers

    Which chemical class does phenobarbital belong to?

    <p>Amide</p> Signup and view all the answers

    What kind of compound is urea?

    <p>Amide</p> Signup and view all the answers

    What is the chemical classification of the barbiturate sedatives?

    <p>Cyclic amides</p> Signup and view all the answers

    Amines having fewer than ___ carbons are generally water soluble.

    <p>Six</p> Signup and view all the answers

    Aniline is the IUPAC approved name for aminobenzene.

    <p>True (A)</p> Signup and view all the answers

    Aniline is a primary amine.

    <p>True (A)</p> Signup and view all the answers

    Ethylmethylamine is a tertiary amine.

    <p>False (B)</p> Signup and view all the answers

    The amine functional group is rarely found in pharmacologically active compounds.

    <p>False (B)</p> Signup and view all the answers

    Primary amines contain two carbon-containing groups bonded to the nitrogen atom.

    <p>False (B)</p> Signup and view all the answers

    Amines do not form hydrogen bonds.

    <p>False (B)</p> Signup and view all the answers

    Amines do not ionize in water.

    <p>False (B)</p> Signup and view all the answers

    Amines act as weak acids by accepting protons from water.

    <p>False (B)</p> Signup and view all the answers

    Amine salts are odorless and usually highly water soluble.

    <p>True (A)</p> Signup and view all the answers

    Quinine is an alkaloid used for treatment of malaria.

    <p>True (A)</p> Signup and view all the answers

    Heterocyclic amines contain a nitrogen atom in a ring.

    <p>True (A)</p> Signup and view all the answers

    Aspirin substitutes may contain amide rather than ester functional groups.

    <p>True (A)</p> Signup and view all the answers

    Amides are bases.

    <p>False (B)</p> Signup and view all the answers

    The compound CH3CH2NHCH3 is an?

    <p>Amine</p> Signup and view all the answers

    When acetic acid reacts with ammonia, NH3, the reaction is called amidation and yields?

    <p>Acetamide</p> Signup and view all the answers

    What is the major functional group in the following compound? O=CH3CNHCH3.

    <p>Amide</p> Signup and view all the answers

    In the formation of N-ethylacetamide, the reactants are?

    <p>Acetic acid and ethylamine</p> Signup and view all the answers

    What is the name of the amide formed in the reaction of benzoic acid and ethylamine?

    <p>N-ethylbenzamide</p> Signup and view all the answers

    What is the name of the amide formed in the reaction of O=CH3CH2CNHCH3?

    <p>N-ethylpropanamide</p> Signup and view all the answers

    The reaction of butanoic acid and dimethylamine gives?

    <p>N,N-dimethylbutanamide</p> Signup and view all the answers

    Amides are derivatives of ___ and ___.

    <p>Amines and carboxylic acids</p> Signup and view all the answers

    Which of the following is the reaction for the acid hydrolysis of N-methylacetamide?

    <p>O\nO\n||\n||\nCH3CNHCH3+H2O+HCl-&gt;CH3COH+CH3NH3+Cl-</p> Signup and view all the answers

    Which of the following is the reaction for the base hydrolysis of N-ethylformamide?

    <p>O\nO\n||\n||\nHCNHCH2CH3+NaOH-&gt;HCO-Na+ + CH3CH2-NH2</p> Signup and view all the answers

    The compound O=CH3CH2CNHCH3 is an?

    <p>Amide</p> Signup and view all the answers

    The correct name for O=HCNHCH2CH3 is?

    <p>N-ethyl formamide</p> Signup and view all the answers

    With the correct choice of acid, acid hydrolysis of acetamide could produce?

    <p>Acetic acid and ammonium chloride</p> Signup and view all the answers

    With the correct choice of acid, the product of the acid hydrolysis of N-methylbenzamide could be?

    <p>Benzoic acid and methylammonium chloride</p> Signup and view all the answers

    What pharmacologically active amine is responsible for the signs and symptoms encountered in an allergic reaction?

    <p>Histamine</p> Signup and view all the answers

    Which of the following is not a neurotransmitter?

    <p>Pyridine (B)</p> Signup and view all the answers

    A neurotransmitter?

    <p>Transmits a nerve impulse</p> Signup and view all the answers

    In response to allergic reactions or injury to cells, the body increases the production of?

    <p>Histamine</p> Signup and view all the answers

    Study Notes

    Amines Classification

    • CH3CH2NHCH3 is a secondary amine.
    • CH3CH2NH2 is a primary amine.
    • (CH3CH2)2NH is classified as an amine.
    • Dimethylamine is designated as CH3-NH-CH3.

    Names and Structures of Amines

    • N-methyl-3-bromoaniline is derived from HNCH3-benzene ring-Br.
    • Aminobenzene is formally referred to as aniline.
    • Ethyldimethylamine is represented as CH3-NCH2CH3-CH3.

    Properties and Functional Groups

    • Amines are nitrogen-containing compounds capable of forming hydrogen bonds.
    • Tertiary amines, like (CH3CH2)3N, do not form hydrogen bonds.
    • Primary amines contain one carbon-containing group bonded to nitrogen, while secondary amines have two.
    • The characteristic functional group in alkaloids is an amine.

    Reaction and Hydrolysis

    • Ethylamine in water creates ethylammonium hydroxide.
    • Diethylamine reacts with HCl to yield diethylammonium chloride.
    • The hydrolysis of amides can produce corresponding acids and amines when treated with acids or bases.

    Biological Significance of Amines

    • Amines can act as Bronsted-Lowry bases.
    • Quaternary ammonium compounds like choline have a positive nitrogen charge.
    • Histamine, an active amine, is associated with allergic reactions.

    Medicinal Chemistry

    • Amine salts are commonly used in drug formulations due to their increased solubility.
    • Alkaloids, including nicotine, quinine, and morphine, are biologically active nitrogen compounds.
    • Local anesthetics such as Procaine and Lidocaine are derived from modifications of cocaine.

    Miscellaneous

    • Heterocyclic compounds are cyclic structures containing nitrogen.
    • Amides are derivatives of amines and carboxylic acids, and are involved in various chemical reactions.
    • Acid and base hydrolysis of amides produces corresponding acids and amines or ammonium salts.

    Boiling Points and Solubility

    • Amines generally have higher boiling points than similar hydrocarbons due to hydrogen bonding.
    • Water solubility of amines decreases with an increasing number of carbon atoms; typically, amines with fewer than six carbon atoms are soluble.

    True/False Statements

    • Aniline is confirmed as a primary aromatic amine.
    • Ethylmethylamine is not a tertiary amine, hence that statement is false.
    • Amine salts and heterocyclic amines like pyrrolidine possess physiological significance and are correctly identified.

    Summary of Reactions

    • Amidation between acetic acid and ammonia yields acetamide.
    • The reaction between benzoic acid and ethylamine produces N-ethylbenzamide, showcasing the amide functionality.
    • Hydrolysis reactions allow amides to revert to their respective acids and amines under the right conditions.

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    Description

    Test your knowledge of amines, including primary and secondary classifications, with these informative flashcards from Chapter 18. This quiz focuses on recognizing and naming various amines and their structures. Perfect for students studying organic chemistry.

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