Chlordiazepoxide Flashcards
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Questions and Answers

What is the trade name for Chlordiazepoxide?

  • Valium
  • Ativan
  • Xanax
  • Librium (correct)
  • Which of the following are classes of Chlordiazepoxide? (Select all that apply)

  • Anti-anxiety agents (correct)
  • Opioids
  • Sedative/hypnotics (correct)
  • Benzodiazepines (correct)
  • What are some indications for the use of Chlordiazepoxide?

  • Managing high blood pressure
  • Adjunct management of anxiety (correct)
  • Treatment of alcohol withdrawal (correct)
  • Treatment of severe pain
  • What is one action of Chlordiazepoxide?

    <p>Sedation</p> Signup and view all the answers

    Which of the following are contraindications for Chlordiazepoxide? (Select all that apply)

    <p>Pulmonary disease</p> Signup and view all the answers

    Chlordiazepoxide is safe for use in pregnant and lactating women.

    <p>False</p> Signup and view all the answers

    Which of the following should be cautiously used with Chlordiazepoxide? (Select all that apply)

    <p>Moderate renal impairment</p> Signup and view all the answers

    Which of the following are common adverse effects of Chlordiazepoxide? (Select all that apply)

    <p>Dizziness</p> Signup and view all the answers

    What should be assessed periodically during Chlordiazepoxide therapy?

    <p>Anxiety and level of sedation</p> Signup and view all the answers

    What lab considerations are necessary for patients on prolonged therapy with Chlordiazepoxide?

    <p>CBC and liver function tests</p> Signup and view all the answers

    Flumazenil can reverse sedation caused by Chlordiazepoxide toxicity.

    <p>True</p> Signup and view all the answers

    What is an important teaching point when discontinuing Chlordiazepoxide?

    <p>Sudden cessation may lead to withdrawal</p> Signup and view all the answers

    Study Notes

    Chlordiazepoxide Overview

    • Trade name: Librium, an anti-anxiety medication within the benzodiazepine class.
    • Used for managing anxiety, treating alcohol withdrawal, and alleviating anxiety linked to acute myocardial infarction.

    Classification and Action

    • Falls under anti-anxiety agents, sedative/hypnotics, and benzodiazepines.
    • Provides sedation and relief of anxiety.

    Contraindications

    • Not suitable for individuals with hypersensitivity to the drug.
    • Contains tartrazine; should be avoided in those with known intolerance.
    • Not recommended for comatose patients or those with severe CNS depression, pulmonary disease, angle-closure glaucoma, or porphyria.
    • Caution advised during pregnancy and lactation due to risks of CNS depression in infants.
    • Avoid in children aged 6 years or younger.

    Cautions and Precautions

    • Use cautiously in patients with hepatic dysfunction, severe renal impairment, or a history of suicide attempts or substance abuse.
    • Long-acting benzodiazepines can cause increased sedation; particularly dangerous for the elderly.
    • Consideration needed for debilitated patients due to increased sensitivity.

    Adverse Effects

    • Common side effects include dizziness, drowsiness, fatigue, headache, mental depression, and blurred vision.
    • May cause paradoxical excitation, weight gain, rashes, and dependence leading to tolerance.

    Drug Interactions

    • Concurrent use with alcohol, antidepressants, antihistamines, and opioids can increase CNS depression.
    • Certain medications (cimetidine, oral contraceptives, etc.) may enhance the drug's effects; rifampin/barbiturates may reduce effectiveness.
    • Herbal products like kava-kava and valerian can similarly amplify CNS depression.

    Assessment and Monitoring

    • Regular assessment for anxiety levels and sedation during therapy is crucial.
    • Monitor for signs of withdrawal if therapy is prolonged; restrict drug supply for at-risk patients.
    • In alcohol withdrawal cases, observe signs like tremors or agitation, with appropriate injury precautions.

    Laboratory Considerations

    • CBC and liver function tests should be periodically evaluated for patients on long-term therapy.
    • Chlordiazepoxide may elevate serum bilirubin and liver enzymes (AST, ALT).

    Toxicity and Overdose

    • Flumazenil can reverse sedation caused by chlordiazepoxide overdose.

    Patient Education

    • Gradual tapering required after long-term use to prevent withdrawal symptoms.
    • Advise against sharing medication due to potential dangers.
    • Warn about risks of drowsiness/dizziness; avoid driving until effects are known.
    • Caution to avoid alcohol and CNS depressants concurrently.
    • Instruct on disclosing all medications (Rx and OTC), vitamins, or herbal products to healthcare professionals.
    • Notify healthcare providers about pregnancy plans or if breastfeeding.

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    Description

    This quiz consists of flashcards focusing on Chlordiazepoxide, a benzodiazepine used as an anti-anxiety agent. The flashcards cover its trade name, classifications, indications, actions, and contraindications. Ideal for students learning about pharmacology and medication classifications.

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