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Questions and Answers
What is considered the prime determinant of potency of a Local Anesthetic Agent (LAA)?
What is considered the prime determinant of potency of a Local Anesthetic Agent (LAA)?
- Molecular weight
- Charge
- Solubility
- Hydrophobicity (correct)
Why do hydrophobic agents have better potency in theory?
Why do hydrophobic agents have better potency in theory?
- They are larger in size
- They penetrate cell membranes better (correct)
- They are better at vasoconstriction
- They have a higher charge
What is the significance of pKa value for a Local Anesthetic Agent?
What is the significance of pKa value for a Local Anesthetic Agent?
- It represents the solubility of the LAA
- It measures the charge of the LAA
- It indicates the molecular weight of the LAA
- It shows the pH at which basic and ionic forms are equal (correct)
Why do protonated charged molecules have decreased efficacy as Local Anesthetic Agents?
Why do protonated charged molecules have decreased efficacy as Local Anesthetic Agents?
In what type of environment are protonated charged molecules more predominant?
In what type of environment are protonated charged molecules more predominant?
What influences the availability of Local Anesthetic Agents at the action site apart from hydrophobicity?
What influences the availability of Local Anesthetic Agents at the action site apart from hydrophobicity?
What effect does higher dosage of local anesthetic agents have on anesthesia?
What effect does higher dosage of local anesthetic agents have on anesthesia?
Why is vasoconstrictor like adrenaline combined with local anesthetic agents?
Why is vasoconstrictor like adrenaline combined with local anesthetic agents?
Which type of nerve fibers are more susceptible to local anesthetic agents?
Which type of nerve fibers are more susceptible to local anesthetic agents?
What principle is utilized in tumescent anesthesia regarding the dosage of local anesthetic agents?
What principle is utilized in tumescent anesthesia regarding the dosage of local anesthetic agents?
How does lidocaine affect blood vessels at lower concentrations?
How does lidocaine affect blood vessels at lower concentrations?
Why is the combination of lidocaine, tetracaine, and phenylephrine preferred over benzocaine 20%?
Why is the combination of lidocaine, tetracaine, and phenylephrine preferred over benzocaine 20%?
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