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CheckMate 77T Study: Neoadjuvant Nivolumab in NSCLC

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CheckMate 77T Study: Neoadjuvant Nivolumab in NSCLC

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Questions and Answers

In the CheckMate 8HW study, what is the primary tumor location used as a stratification factor?

Left

Colon

Rectum

Right (correct)

What is the recommended dosage of Nivolumab in the 1L setting in the CheckMate 8HW study?

240 mg Q4W for 6 doses, followed by 480 mg Q2W

480 mg Q4W for 6 doses, followed by 240 mg Q2W

480 mg Q2W for 6 doses, followed by 240 mg Q4W

240 mg Q2W for 6 doses, followed by 480 mg Q4W (correct)

Which type of cancer was the focus of the CheckMate 8HW study?

Colorectal cancer (correct)

Breast cancer

Prostate cancer

Lung cancer

What is the status required for patients to be eligible for the CheckMate 8HW study?

MSI-H/dMMR Signup and view all the answers

Which phase of the study compared Nivolumab + Ipilimumab with Nivolumab or chemotherapy?

Phase 3 Signup and view all the answers

In the CheckMate 8HW study, what was the primary objective of comparing Nivolumab plus ipilimumab to chemotherapy?

To assess overall survival in patients with microsatellite instabilityhigh/ mismatch repair-deficient metastatic colorectal cancer Signup and view all the answers

What was the major finding of the CheckMate 8HW study regarding the comparison between Nivolumab plus ipilimumab and chemotherapy?

Significantly improved overall survival with Nivolumab plus ipilimumab in patients with microsatellite instabilityhigh/ mismatch repair-deficient metastatic colorectal cancer Signup and view all the answers

What is the implication of the CheckMate 8HW study results for the first-line treatment of microsatellite instabilityhigh/ mismatch repair-deficient metastatic colorectal cancer?

Nivolumab plus ipilimumab should be the standard first-line treatment Signup and view all the answers

What aspect of the CheckMate 8HW study design contributed to its significance in the field of oncology?

Comparison of two immunotherapies with distinct mechanisms of action Signup and view all the answers

What is the potential implication of the CheckMate 8HW study results on the future development of treatment guidelines for colorectal cancer?

Continued evaluation and validation of the study findings in real-world clinical settings Signup and view all the answers