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Questions and Answers
Match the laxative with its associated drug class.
Match the laxative with its associated drug class.
Osmotic = Lactulose Stimulant = Bisacodyl Selective Chloride Channel Activator = Lubiprostone Emollient = Docusate sodium
Lubiprostone is quickly metabolized in the stomach and jejunum by the cytochrome P450 (CYP450) system.
Lubiprostone is quickly metabolized in the stomach and jejunum by the cytochrome P450 (CYP450) system.
False (B)
In which time frame would a nurse expect to note the effects of oral bisacodyl in a patient?
In which time frame would a nurse expect to note the effects of oral bisacodyl in a patient?
6 to 12 hours
To which classification of antidiarrheal drugs does bismuth subsalicylate belong?
To which classification of antidiarrheal drugs does bismuth subsalicylate belong?
Which statements regarding the pharmacodynamic parameters of loperamide are accurate? (Select all that apply)
Which statements regarding the pharmacodynamic parameters of loperamide are accurate? (Select all that apply)
Which patient parameters would a nurse ensure are assessed before administering bisacodyl to a 17-year-old female patient? (Select all that apply)
Which patient parameters would a nurse ensure are assessed before administering bisacodyl to a 17-year-old female patient? (Select all that apply)
A nurse determines that patients with which conditions can safely receive laxative therapy?
A nurse determines that patients with which conditions can safely receive laxative therapy?
What outcome would a nurse anticipate will occur due to a drug interaction in a patient taking psyllium and prescribed tetracycline?
What outcome would a nurse anticipate will occur due to a drug interaction in a patient taking psyllium and prescribed tetracycline?
I can expect the laxative effect of glycerin to occur in about 1 hour.
I can expect the laxative effect of glycerin to occur in about 1 hour.
Which adverse effects should a nurse monitor for in a patient receiving lubiprostone for irritable bowel syndrome? (Select all that apply)
Which adverse effects should a nurse monitor for in a patient receiving lubiprostone for irritable bowel syndrome? (Select all that apply)
Which side effects would the nurse alert Mr. Frank to be monitored for while receiving loperamide? (Select all that apply)
Which side effects would the nurse alert Mr. Frank to be monitored for while receiving loperamide? (Select all that apply)
Which patients would a nurse determine cannot safely receive treatment with loperamide without consultation with a health care provider? (Select all that apply)
Which patients would a nurse determine cannot safely receive treatment with loperamide without consultation with a health care provider? (Select all that apply)
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Study Notes
Laxative Classifications
- Osmotic laxative: Lactulose
- Stimulant laxative: Bisacodyl
- Selective Chloride Channel Activator: Lubiprostone
- Emollient laxative: Docusate sodium
Lubiprostone Pharmacokinetics
- Rapidly metabolized in the stomach and jejunum
- Metabolism occurs via carbonyl reductase, not CYP450 system
Bisacodyl Onset of Action
- Oral bisacodyl shows effects within 6 to 12 hours
Bismuth Subsalicylate Classification
- Classified as an adsorbent antidiarrheal
- Functions by lining the gastrointestinal tract to eliminate bacteria and toxins
Loperamide Pharmacodynamics
- Onset of action: 1 hour
- Peak concentration for liquid formulation: 2.5 hours
- Duration of action: 24 hours
Patient Assessment Before Administering Bisacodyl
- Assess renal function (BUN/Serum creatinine)
- Evaluate bowel patterns to determine constipation cause
- Check blood pressure to monitor dehydration risk
- Inquire about history of eating disorders due to potential for abuse
Conditions Allowing Laxative Therapy
- Patients with dyslipidemia, osteoarthritis, or hypothyroidism can safely receive laxatives
Drug Interaction with Psyllium
- Tetracycline absorption is decreased when taken with psyllium
Glycerin Administration Timing
- Glycerin's laxative effect occurs in 16 to 36 minutes, contrary to the 1-hour misconception
Monitoring for Lubiprostone Adverse Effects
- Monitor for severe diarrhea
- Watch for urinary tract infections (UTIs)
- Observe for upper respiratory tract infections
Loperamide Side Effects
- Potential drowsiness
- Risk of urinary retention
Contraindications for Loperamide Treatment
- Avoid use in patients with liver disease due to altered metabolism
- Contraindicated for patients with ulcerative colitis, as diarrhea needs further evaluation
- Consult a healthcare provider for patients with a history of opioid misuse
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