Cervical Screening and HPV

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Questions and Answers

A 24-year-old woman is due for cervical cancer screening. According to current guidelines, which of the following is the most appropriate screening strategy?

  • Pap test alone, repeated every 3 years. (correct)
  • HPV test alone, repeated every 5 years if negative.
  • HPV test alone, repeated every 3 years if negative.
  • Co-testing with HPV and Pap test, repeated every 5 years if both are negative.

A 35-year-old woman undergoing routine cervical cancer screening has a negative Pap test but a positive high-risk HPV test. What is the most appropriate next step in management?

  • Repeat co-testing (Pap and HPV) in 5 years.
  • Perform a colposcopy with possible biopsy. (correct)
  • Administer the HPV vaccine.
  • Repeat HPV testing in 12 months.

The HPV vaccine is most effective when administered:

  • After an individual becomes sexually active and has potentially been exposed to HPV.
  • To treat existing HPV infections.
  • To individuals presenting with genital warts.
  • Before the onset of sexual activity and potential exposure to HPV. (correct)

A 40-year-old woman has been consistently undergoing cervical cancer screening with normal results. She asks if she can discontinue screening now. Which of the following most accurately reflects current guidelines?

<p>Screening can be discontinued at age 65 if there is a history of adequate prior screening and no history of high-grade precancerous lesions or cervical cancer. (C)</p> Signup and view all the answers

Which of the following is the primary purpose of cervical cancer screening?

<p>To detect and treat precancerous cervical lesions before they progress to invasive cancer. (C)</p> Signup and view all the answers

What is the MOST critical factor in determining the appropriate interval for cervical cancer screening?

<p>Patient age and prior screening history. (C)</p> Signup and view all the answers

Which of the following represents an established risk factor for the development of cervical cancer?

<p>Infection with high-risk types of Human Papillomavirus (HPV) (B)</p> Signup and view all the answers

A patient presents with visible genital warts. Besides treatment of the warts, which additional diagnostic step is MOST important?

<p>Testing for other sexually transmitted infections (STIs). (A)</p> Signup and view all the answers

Which treatment modality involves the application of a chemical agent to destroy cells affected by genital warts?

<p>TCA (Trichloroacetic acid) (A)</p> Signup and view all the answers

A patient diagnosed with a low-grade cervical abnormality on Pap test is co-infected with HIV. How does this typically influence the management approach?

<p>The threshold for intervention is lowered, and more aggressive management is often warranted. (D)</p> Signup and view all the answers

What is the primary mechanism by which the HPV vaccine prevents cervical cancer?

<p>Stimulating the immune system to produce antibodies against specific HPV types. (A)</p> Signup and view all the answers

Which of the following factors is LEAST likely to influence the progression of an HPV infection to cervical cancer?

<p>Geographic location. (C)</p> Signup and view all the answers

A woman reports having the HPV vaccine at age 28. How does this impact her cervical cancer screening recommendations?

<p>She should follow standard cervical cancer screening guidelines based on her age. (C)</p> Signup and view all the answers

What is the rationale behind using liquid-based cytology in Pap tests?

<p>It allows for ancillary testing such as HPV testing from the same sample. (B)</p> Signup and view all the answers

What is the MOST common initial symptom if a patient has cervical cancer?

<p>Abnormal vaginal bleeding (B)</p> Signup and view all the answers

Which population below has the HIGHEST risk for cervical cancer?

<p>Smokers (D)</p> Signup and view all the answers

For women that are 30-65, which option is not a screening option for cervical cancer?

<p>Blood test (C)</p> Signup and view all the answers

Which of the treatment options is not appropriate for treating "genital warts?"

<p>Antibiotics (C)</p> Signup and view all the answers

What is the MOST common cause of cervical cancer?

<p>HPV (D)</p> Signup and view all the answers

How often should a Pap test be done if the results are normal?

<p>It depends on the age of the patient (A)</p> Signup and view all the answers

Flashcards

What is a Pap Smear?

The process where cells are scraped from the cervix and examined under a microscope to check for diseases or other problems.

Cervical Screening

A screening method similar to a Pap smear that specifically looks for Human Papilloma Virus (HPV) infection, the #1 cause of cervical cancer.

Cervical screening guidelines for women aged 21-29

Women aged 21-29 should have a Pap test alone every 3 years, while HPV testing is not recommended.

Cervical screening guidelines for women aged 30-65

Women aged 30–65 years have 3 options: Pap test only (normal result can wait 3 years), HPV test only (normal result can wait 5 years), or HPV and Pap test (preferred, normal result can wait 5 years).

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HPV Vaccine

Protects against the types of HPV that most often cause cervical cancers and other cancers in both men and women.

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HPV vaccination age recommendations

The HPV vaccine is recommended for all individuals aged 11-26 years who have not been previously vaccinated. It can be given as early as 9 years old.

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HPV vaccine FDA

Approved by the FDA in 2018 for women and men up to age 45. Many adults may have been exposed to some strains of HPV. The vaccine covers 9 types.

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HPV vaccine limitations

The HPV vaccine does not treat existing infections or diseases; screening should be continued even if a person is vaccinated.

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Chondyloma

Also known as genital warts, caused by HPV.

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Genital warts management

Genital warts may require biopsy for dysplasia or carcinoma, and testing for other concurrent STIs. Treatment options include podofilox gel 0.5%, TCA (Trichloroacetic acid), or cryotherapy.

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Study Notes

  • Cervical Screening/HPV by Kaneez R. Odgers DNP, FNP-BC

Pap Smear

  • Cells are scraped from the cervix and examined under a microscope for disease or other problems.
  • The cervix is viewed through a speculum with the patient in lithotomy position.
  • A Pap smear is also referred to as a PAP test.

Cervical Screening

  • A Cervical Screening is similar to a PAP smear
  • It specifically screens for Human Papilloma Virus (HPV) infection.
  • HPV is the number one cause of cervical cancer.

Cervical Screening Guidelines

  • Women aged 21-29 should have a Pap test alone every 3 years
    • HPV testing is not recommended for this age group
  • Women aged 30-65 have the following options:
    • Pap test only with a normal result allowing a 3 year wait.
    • HPV test only with a normal result allowing a 5 year wait.
    • HPV and Pap test (preferred) with a normal result allowing a 5 year wait.

HPV Vaccine

  • It protects against the types of HPV that most often cause cervical cancers.
  • HPV can also cause other kinds of cancer in both men and women.
  • HPV vaccination is recommended for individuals aged 11-26 years who have not been previously vaccinated.
    • It can be given as early as 9 years old.
  • In 2018, the FDA approved the vaccine for women and men up to age 45.
    • Many adults have been exposed to some strains of HPV; however, most have not been exposed to all nine types covered by the vaccine.
  • The HPV vaccine does not treat existing infections or diseases.
  • Screening should be continued even if a person is vaccinated.

Chondyloma (HPV)

  • Also referred to as "Genital Warts"
  • May require biopsy to rule out (r/o) dysplasia or carcinoma.
  • May require testing for other concurrent STI's.

Treatment

  • Podofilox gel 0.5%
  • TCA (Trichloroacetic acid)
  • Cryotherapy

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