Cephalosporin Generations

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Questions and Answers

A patient requires a cephalosporin antibiotic, and the treatment plan necessitates a third-generation drug. Which of the following would be the MOST appropriate choice?

  • Ceftriaxone (correct)
  • Cefoxitin
  • Cefazolin
  • Cefepime

A hospital pharmacist is reviewing a patient's medication list and notices they are prescribed cefprozil. To which generation of cephalosporins does cefprozil belong?

  • Fourth generation
  • Second generation (correct)
  • First generation
  • Third generation

A patient has a severe penicillin allergy, and their doctor wants to prescribe a cephalosporin with caution. Considering the generations of cephalosporins, which characteristic is MOST important to consider regarding potential cross-reactivity?

  • The specific side chain structures of the cephalosporin. (correct)
  • The method of synthesis of the cephalosporin.
  • The generation of the cephalosporin, with later generations being safer.
  • The cost of the cephalosporin formulation.

Which of the following cephalosporins is classified as a fifth-generation antibiotic?

<p>Ceftaroline (D)</p> Signup and view all the answers

A patient requires treatment for a bacterial infection, and the chosen cephalosporin ends in 'IME'. Based on this suffix, to which generation does this cephalosporin MOST likely belong?

<p>Fourth (C)</p> Signup and view all the answers

A microbiologist is studying the mechanism of action of cephalosporin antibiotics. What is the PRIMARY target of these drugs in bacterial cells?

<p>Inhibition of bacterial cell wall synthesis. (C)</p> Signup and view all the answers

A researcher is investigating novel cephalosporin derivatives. In which generation would a cephalosporin containing the suffix 'ROL' most likely be classified?

<p>Fifth (B)</p> Signup and view all the answers

A hospital is trying to minimize the use of broad-spectrum antibiotics to prevent the spread of antibiotic-resistant bacteria. Which of the following strategies would BEST align with this goal when prescribing cephalosporins?

<p>Use a first-generation cephalosporin when it is appropriate for the infection. (A)</p> Signup and view all the answers

A patient is prescribed cefazolin prior to surgery to prevent infection. To which generation of cephalosporins does cefazolin belong?

<p>First generation (B)</p> Signup and view all the answers

Which of the following cephalosporins is MOST likely to be effective against methicillin-resistant Staphylococcus aureus (MRSA)?

<p>Ceftaroline (B)</p> Signup and view all the answers

Flashcards

Cephalosporin Antibiotics

Beta-lactam antibiotics classified into 5 generations.

1st Generation Cephalosporins

First-generation cephalosporins, like Cefazolin and Cephalexin.

2nd Generation Cephalosporins

Second-generation cephalosporins, including Cefoxitin and Cefotetan.

3rd Generation Cephalosporins

Third-generation cephalosporins, such as Ceftriaxone and Ceftazidime.

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4th Generation Cephalosporins

Fourth-generation cephalosporins, like Cefepime.

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5th Generation Cephalosporins

Fifth-generation cephalosporins, including Ceftaroline.

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Cefazolin generation

Cefazolin belongs to this generation.

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Ceftriaxone generation

Ceftriaxone belongs to this generation

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Study Notes

  • Cephalosporin antibiotics are Beta-lactam antibiotics
  • These antibiotics are grouped into 5 generations

1st Generation

  • Mnemonic: "FA/PHA"
  • CEFAZOLIN
  • CEFADROXIL
  • CEPHALEXIN
  • CEPHALOTHIN
  • CEPHAPIRIN
  • CEPHRADINE

2nd Generation

  • Mnemonic: "Everything Else"
  • CEFOXITIN
  • CEFOTETAN
  • CEFMETAZOLE
  • CEFPROZIL

3rd Generation

  • Mnemonic: "ONE/TEN/IME"
  • CEFTRIAXONE
  • CEFTIBUTEN
  • CEFOTAXIME
  • CEFTAZIDIME
  • CEFPODOXIME
  • CEFIXIME

4th Generation

  • Mnemonic: "PI"
  • CEFEPIME
  • CEFPIROME

5th Generation

  • Mnemonic: "ROL"
  • CEFTAROLINE
  • CEFTOBIPROLE

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