Centrally Acting Muscle Relaxants

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Questions and Answers

Which of the following best describes the primary mechanism of action for centrally acting muscle relaxants?

  • Blocking pain receptors in the brain to alleviate discomfort associated with muscle conditions.
  • Increasing the release of acetylcholine in the peripheral nervous system.
  • Directly relaxing skeletal muscles at the neuromuscular junction.
  • Interfering with the reflexes in the central nervous system to reduce muscle spasm. (correct)

A patient with a history of which condition would be most likely to have a contraindication to centrally acting muscle relaxants?

  • Osteoporosis
  • Epilepsy (correct)
  • Hypertension
  • Diabetes

What is the most common intended therapeutic effect of centrally acting muscle relaxants?

  • Improving cardiovascular function
  • Increasing muscle strength
  • Relieving discomfort from acute musculoskeletal conditions (correct)
  • Reducing inflammation

Which of the following adverse effects is most likely to be associated with centrally acting muscle relaxants?

<p>Central nervous system depression (A)</p> Signup and view all the answers

Why is it important to avoid the concurrent use of alcohol and centrally acting muscle relaxants?

<p>Because it intensifies the CNS depressant effects. (A)</p> Signup and view all the answers

A patient taking a centrally acting muscle relaxant reports feeling dizzy upon standing. What is the most likely cause of this?

<p>Hypotension (D)</p> Signup and view all the answers

Centrally acting muscle relaxants should be avoided in patients experiencing spasms resulting from what condition?

<p>Rheumatic disorders (D)</p> Signup and view all the answers

Which of the following conditions represents a major contraindication for the use of centrally acting muscle relaxants due to potential adverse effects?

<p>Hepatic or renal dysfunction (A)</p> Signup and view all the answers

Concurrent use of MAOIs (Monoamine Oxidase Inhibitors) with centrally acting muscle relaxants should be approached with caution because of the increased risk of what?

<p>Increased risk of adverse CNS effects (D)</p> Signup and view all the answers

Which of the following best explains why pregnancy is listed as a contraindication for centrally acting muscle relaxants?

<p>The effects on the fetus are not well-established, posing potential risks. (B)</p> Signup and view all the answers

Flashcards

Centrally Acting Relaxants

Works in the CNS to interfere with the reflexes causing muscle spasm.

Examples of Muscle Relaxants

Baclofen, carisoprodol, methocarbamol, cyclobenzaprine, tizanidine, chlorzoxazone.

Indications for Use

Relief of discomfort associated with acute, painful musculoskeletal conditions.

Contraindication of Muscle Relaxants

Spasms resulting from rheumatic disorders.

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Contraindications

Epilepsy, cardiac dysfunction, hepatic or renal dysfunction, pregnancy and lactation.

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Adverse Effects

CNS depressant, hypotension, dyspnea, dizziness, altered mental status, hepatic dysfunction.

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Drug-Drug Interactions

Alcohol, MAOIs, antihistamines, other CNS depressants.

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Study Notes

  • Centrally acting muscle relaxants work in the CNS to interfere with reflexes causing muscle spasm

Names

  • Baclofen
  • Carisoprodol
  • Methocarbamol
  • Cyclobenzaprine
  • Tizanidine
  • Chlorzoxazone

Indications

  • Provides relief of discomfort associated with acute, painful musculoskeletal conditions

Contraindication

  • Spasms resulting from rheumatic disorders

Contraindications

  • Epilepsy
  • Cardiac dysfunction
  • Hepatic or renal dysfunction
  • Pregnancy and lactation

Adverse Effects

  • CNS depressant
  • Hypotension
  • Dyspnea
  • Dizziness
  • Altered mental status
  • Hepatic dysfunction

Drug-Drug

  • Alcohol
  • MAOIs
  • Antihistamines
  • Other CNS depressants

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