Podcast
Questions and Answers
Which muscle relaxant is classified as a benzodiazepine?
Which muscle relaxant is classified as a benzodiazepine?
- Tolperisone
- Diazepam (correct)
- Carisoprodol
- Tizanidine
What is the mechanism of action for tolperisone?
What is the mechanism of action for tolperisone?
- GABA receptor antagonist
- Alpha-2 agonist
- Unknown mechanism (correct)
- Benzodiazepine receptor modulator
Which centrally acting muscle relaxant has potential for abuse?
Which centrally acting muscle relaxant has potential for abuse?
- Tolperisone
- Tizanidine
- Diazepam
- Carisoprodol (correct)
What type of agonist is tizanidine classified as?
What type of agonist is tizanidine classified as?
What is a known side effect of meprobamate, the metabolite of carisoprodol?
What is a known side effect of meprobamate, the metabolite of carisoprodol?
What is true regarding the mechanism of action of mephenesine and guaifenesine?
What is true regarding the mechanism of action of mephenesine and guaifenesine?
Which centrally acting muscle relaxant is specifically indicated for treating spasticity?
Which centrally acting muscle relaxant is specifically indicated for treating spasticity?
Which muscle relaxant is primarily used for acute muscle spasms?
Which muscle relaxant is primarily used for acute muscle spasms?
Which of the following centrally acting muscle relaxants decreases spinal cord excitability?
Which of the following centrally acting muscle relaxants decreases spinal cord excitability?
What is a significant concern associated with the metabolite of carisoprodol?
What is a significant concern associated with the metabolite of carisoprodol?
Study Notes
Centrally Acting Muscle Relaxants
- Diazepam is a benzodiazepine used to treat acute and chronic muscle spasms.
- Tizanidine, an α2-agonist, is structurally similar to clonidine and also treats both acute and chronic muscle spasms.
- Tolperisone's mechanism of action is unknown but it's used to treat spasms.
- Carisoprodol is used for spasms, its active metabolite is meprobamate, which has the potential for abuse and is hepatotoxic.
Centrally Acting Muscle Relaxants
- These drugs decrease abnormally high muscle tone without affecting voluntary movements.
Spasticity (Chronic Muscle Spasms)
- Baclofen is a GABAg agonist, highly sedative.
Acute Muscle Spasms
- Mephenesine, guaifenesine and chlorzoxazone have unknown mechanisms of action and are used to treat acute spasms.
Drugs for Both Acute and Chronic Spasms
- Diazepam, a benzodiazepine, is used for both acute and chronic spasms.
- Tizanidine, an a2 agonist, is structurally related to clonidine and has an imidazoline core.
- Tolperisone's mechanism of action is unknown.
- Carisoprodol is abused and its metabolite, meprobamate, is hepatotoxic.
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Description
This quiz covers the key centrally acting muscle relaxants including Diazepam, Tizanidine, Tolperisone, and Carisoprodol. Understand their mechanisms, uses, and potential side effects to grasp their therapeutic roles better. Test your knowledge on these important pharmacological agents.
