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Questions and Answers
Which of the following is NOT a characteristic symptom of Horner's syndrome?
Which of the following is NOT a characteristic symptom of Horner's syndrome?
Which neurotransmitter is associated with an increased concentration in the spinal cord of individuals with fibromyalgia?
Which neurotransmitter is associated with an increased concentration in the spinal cord of individuals with fibromyalgia?
Which of the following is a characteristic of Autism Spectrum Disorder (ASD)?
Which of the following is a characteristic of Autism Spectrum Disorder (ASD)?
What type of nerve fiber conducts signals related to discriminative touch, pressure, and joint rotation?
What type of nerve fiber conducts signals related to discriminative touch, pressure, and joint rotation?
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What is the primary complaint of individuals with Complex Regional Pain Syndrome (CRPS)?
What is the primary complaint of individuals with Complex Regional Pain Syndrome (CRPS)?
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What is the main function of the cerebellum?
What is the main function of the cerebellum?
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Which artery primarily supplies blood to the frontal and parietal lobes?
Which artery primarily supplies blood to the frontal and parietal lobes?
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The central sulcus separates which two gyri?
The central sulcus separates which two gyri?
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What type of neuron carries the information from the first neuron to be communicated?
What type of neuron carries the information from the first neuron to be communicated?
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What is one of the primary functions of the brain stem?
What is one of the primary functions of the brain stem?
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What is the primary role of the sympathetic nervous system (SNS)?
What is the primary role of the sympathetic nervous system (SNS)?
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Which of the following characterizes compensation in neural recovery?
Which of the following characterizes compensation in neural recovery?
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What does the principle of 'use it or lose it' signify in experience-dependent neuroplasticity?
What does the principle of 'use it or lose it' signify in experience-dependent neuroplasticity?
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Which option best describes experience-expectant plasticity?
Which option best describes experience-expectant plasticity?
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What neurotransmitters are primarily involved in the postganglionic pathways of the SNS?
What neurotransmitters are primarily involved in the postganglionic pathways of the SNS?
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In what way does the parasympathetic nervous system (PSNS) function at rest?
In what way does the parasympathetic nervous system (PSNS) function at rest?
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What is a critical period in the context of neural development?
What is a critical period in the context of neural development?
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What does the term 'antinociception' refer to?
What does the term 'antinociception' refer to?
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How do cochlear implants affect auditory cortex development when implanted at an earlier age?
How do cochlear implants affect auditory cortex development when implanted at an earlier age?
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What is the primary function of the first order neuron in the sensory pathway?
What is the primary function of the first order neuron in the sensory pathway?
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Which layer forms the sensory organs and the nervous system during embryonic development?
Which layer forms the sensory organs and the nervous system during embryonic development?
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What structure develops into the cerebral hemispheres during brain formation?
What structure develops into the cerebral hemispheres during brain formation?
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What happens during synaptogenesis?
What happens during synaptogenesis?
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What is the role of axons in nerve function?
What is the role of axons in nerve function?
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In which stage of development does the neural tube form?
In which stage of development does the neural tube form?
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Which condition results from the failure of the anterior neural tube to close?
Which condition results from the failure of the anterior neural tube to close?
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Which embryonic section of the somite develops into the dermis?
Which embryonic section of the somite develops into the dermis?
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What type of cells primarily increase in number immediately after the neural tube closes?
What type of cells primarily increase in number immediately after the neural tube closes?
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What type of spina bifida occurs when there is a bony defect but no protrusion of the spinal cord?
What type of spina bifida occurs when there is a bony defect but no protrusion of the spinal cord?
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Which part of the neuron is responsible for generating the action potential?
Which part of the neuron is responsible for generating the action potential?
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During which week of gestation does myelination of axons begin?
During which week of gestation does myelination of axons begin?
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What do axons group together to form in the CNS?
What do axons group together to form in the CNS?
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What is the primary responsibility of neuroglia in the nervous system?
What is the primary responsibility of neuroglia in the nervous system?
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What is the most severely affected sensation in the case of demyelination?
What is the most severely affected sensation in the case of demyelination?
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What results from a complete transection of the spinal cord?
What results from a complete transection of the spinal cord?
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In Brown-Sequard syndrome, which sensation is interrupted ipsilaterally at the level of the lesion?
In Brown-Sequard syndrome, which sensation is interrupted ipsilaterally at the level of the lesion?
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What type of imaging technique uses a contrast medium to visualize blood vessels?
What type of imaging technique uses a contrast medium to visualize blood vessels?
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Which sensory receptors are primarily involved in responding to tissue-damaging stimuli?
Which sensory receptors are primarily involved in responding to tissue-damaging stimuli?
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What type of spinal cord lesion would result in loss of discriminative touch below the level of the lesion ipsilaterally?
What type of spinal cord lesion would result in loss of discriminative touch below the level of the lesion ipsilaterally?
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Which imaging technique is best for detecting ischemic strokes?
Which imaging technique is best for detecting ischemic strokes?
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Which part of the spinal cord does the anterior spinal artery primarily supply?
Which part of the spinal cord does the anterior spinal artery primarily supply?
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Which sensory tract is responsible for nociception, temperature, and crude touch?
Which sensory tract is responsible for nociception, temperature, and crude touch?
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What aspect of sensory function is primarily assessed with an EEG?
What aspect of sensory function is primarily assessed with an EEG?
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Which type of receptor responds specifically to temperature gradients across the skin?
Which type of receptor responds specifically to temperature gradients across the skin?
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What is the primary function of phasic receptors?
What is the primary function of phasic receptors?
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What sensory information does the DCML pathway carry?
What sensory information does the DCML pathway carry?
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What general area does the spinal cord extend from and to?
What general area does the spinal cord extend from and to?
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In case of a lesion in the thalamus, what is the expected sensory loss?
In case of a lesion in the thalamus, what is the expected sensory loss?
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Flashcards
Circle of Willis
Circle of Willis
A network of arteries supplying blood to the cerebral hemispheres.
Frontal Lobe Functions
Frontal Lobe Functions
Responsible for motor skills, planning, and personality.
Cerebellum Function
Cerebellum Function
Coordinates movement, balance, and sensory input regulation.
Cranial Nerve Nuclei
Cranial Nerve Nuclei
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Presynaptic and Postsynaptic Neurons
Presynaptic and Postsynaptic Neurons
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Spina Bifida Prevention
Spina Bifida Prevention
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Cerebral Palsy
Cerebral Palsy
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Signs of Autism
Signs of Autism
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Horner’s Syndrome
Horner’s Syndrome
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Complex Regional Pain Syndrome
Complex Regional Pain Syndrome
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Neural Plasticity
Neural Plasticity
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Recovery vs Compensation
Recovery vs Compensation
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Experience-Expectant Plasticity
Experience-Expectant Plasticity
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Critical Period
Critical Period
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Constraint-Induced Movement Therapy
Constraint-Induced Movement Therapy
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Use it or Lose it
Use it or Lose it
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Autonomic Nervous System
Autonomic Nervous System
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Sympathetic Nervous System (SNS)
Sympathetic Nervous System (SNS)
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Antinociception
Antinociception
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Referred Pain
Referred Pain
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Contralateral
Contralateral
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Demyelination
Demyelination
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Nerve Root Lesion
Nerve Root Lesion
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Brown-Sequard Syndrome
Brown-Sequard Syndrome
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Posterior Column Lesion
Posterior Column Lesion
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Anterior Cord Lesion
Anterior Cord Lesion
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Thalamus Lesion
Thalamus Lesion
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DCML Pathway
DCML Pathway
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Spinothalamic Tract
Spinothalamic Tract
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PET Scan
PET Scan
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CT Scan
CT Scan
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MRI
MRI
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EEG
EEG
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Proprioceptors
Proprioceptors
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Mechanoreceptors
Mechanoreceptors
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First Order Neuron
First Order Neuron
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Second Order Neuron
Second Order Neuron
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Third Order Neuron
Third Order Neuron
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Neuron Parts
Neuron Parts
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Axon Function
Axon Function
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Dendrite Role
Dendrite Role
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Neuroglia
Neuroglia
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Neurulation
Neurulation
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Somite Development
Somite Development
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Ectoderm
Ectoderm
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Myotome
Myotome
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Spina Bifida
Spina Bifida
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Anencephaly
Anencephaly
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Study Notes
Central Nervous System (CNS) Anatomy and Function
- CNS comprises the brain, spinal cord, and cranial nerves 1 & 2.
- Major regions include the spinal cord, brainstem, cerebellum, and cerebrum.
Cerebral Blood Supply
- Circle of Willis: network supplying blood to cerebral hemispheres.
- Anterior Cerebral Artery (ACA): medial surface of frontal and parietal lobes.
- Middle Cerebral Artery (MCA): internal capsule, globus pallidus, putamen, caudate, and most lateral hemispheres.
- Posterior Cerebral Artery (PCA): midbrain, occipital lobe, medial/inferior temporal lobe.
Brain Lobes and Functions
- Frontal Lobe: motor control, executive function, planning, personality.
- Parietal Lobe: sensation.
- Temporal Lobe: language, hearing.
- Occipital Lobe: vision.
Brainstem Function
- Vital functions: cardiovascular activity, respiration.
- Conveys information from cerebrum and spinal cord via tracts.
- Cranial nerve nuclei housed within the brainstem.
- Supports consciousness.
Brain Structure and Function
- Sulci and Gyri: folds that separate areas.
- Longitudinal fissure: separates hemispheres.
- Central sulcus: separates precentral & postcentral gyri (frontal lobe).
- Parieto-occipital sulcus: separates parietal & occipital lobes.
Information Transmission
- Presynaptic neuron: transmits information.
- Postsynaptic neuron: receives information.
- Action potential/nerve impulse: carries signal between cells.
Cerebellum Function
- Involved in motor and non-motor domains.
- Motor behavior regulation: coordination, balance, modulation.
- Sensory input: unconscious proprioception.
- Sensory loss from injury is ipsilateral.
Compression and Lesion Effects
-
Compression can cause paresthesia.
-
Sensory loss after injury: varies based on location and tract affected.
- Nerve root lesion: dermatomal pattern sensory loss, myotomal motor loss.
- Complete transection: sensory loss below lesion at 1-2 levels.
- Hemisecting lesion (Brown-Séquard syndrome):
- Contralateral pain and temperature interruption below lesion.
- Ipsilateral pain & temperature interruption at lesion.
- Ipsilateral loss of discriminative touch and conscious proprioception below lesion.
- Posterior column lesions: loss of conscious proprioception, vibration, and 2-point discrimination below lesion.
- Anterior cord lesion: loss of pain, temperature, and crude touch below lesion.
- Brainstem lesion: contralateral or ipsilateral signs based on location.
- Thalamus lesion: contralateral decrease or loss of sensation.
- Somatosensory cortex lesion: contralateral impairments of discriminative sensations.
Spinal Cord Anatomy and Blood Supply
- Extends from foramen magnum to L1 vertebra (ends at conus medullaris).
- Blood supply via three arteries.
- Anterior spinal artery (anterior ⅔ of cord).
- Posterior spinal arteries (posterior ⅓ of cord).
- Dorsal (sensory) and ventral (motor) roots form nerve roots.
Imaging Techniques
- PET: assesses blood flow and O2/glucose consumption, uses radioactive material.
- CT: 2D reconstruction from X-rays, shows bones.
- MRI: detailed soft tissue imaging via strong magnetic fields.
- MRA: detailed blood vessel imaging, contrast medium used.
- BOLD MRI: measures oxygen consumption for brain function, no radioactive material.
- DTI: measures water diffusion in axons for white matter tract imaging.
- EEG: records cortical electrical activity, helpful for detecting seizures.
Sensory Receptors
- Exteroreceptors: external environment.
- Interoreceptors: internal environment.
- Proprioceptors: joint position sense.
- Tonic receptors: slowly adapting.
- Phasic receptors: rapidly adapting.
- Mechanoreceptors: mechanical deformation.
- Thermoreceptors: temperature change.
- Nociceptors: tissue damage.
- Chemoreceptors: chemical constituents.
Dorsal Column-Medial Lemniscus (DCML) Pathway
- Discriminative tactile sensation, kinesthesia/proprioception, stereognosis.
- Heavily myelinated.
- Three-neuron pathway:
- 1st order: enters dorsal column, ascends ipsilaterally to medulla.
- 2nd order: crosses midline, ascends in contralateral dorsal column nuclei to thalamus.
- 3rd order: thalamus to cerebral cortex parietal lobe.
Spinothalamic Tract
- Anterolateral system for nociception, temperature, crude touch.
- Lightly myelinated.
- Three-neuron pathway:
- 1st order: enters spinal cord, synapses in dorsal horn.
- 2nd order: crosses midline, ascends in anterolateral system to thalamus.
- 3rd order: thalamus to cerebral cortex parietal lobe.
Nerve Structure
- Neurons: nerve cells that receive and transmit signals.
- Parts: axon, dendrites, soma.
- Neuroglia: supporting cells that protect, provide metabolic support, and transmit information.
Nerve Damage
- Damage affects nerve function and transmission.
CNS Development
- Zygote: fertilized egg.
- Blastocyst: cells form layers.
- Embryonic stage (2-8 weeks): germ layers form; ectoderm (nervous system), mesoderm (muscles/skeleton), endoderm (internal organs).
- Neural tube: forms CNS.
- Neurulation: formation of neural tube.
- Somite development: forms skin, vertebrae, muscles.
- Brain formation: primary and secondary vesicles (telencephalon, diencephalon, mesencephalon, rhombencephalon)
- Fetal stage (8 weeks - birth): development continues and myelination begins.
- Cellular development: proliferation, migration, differentiation, synaptogenesis, myelination.
Developmental Disorders
- Anencephaly: anterior neural tube failure, skull/brain absence.
- Spina bifida: posterior neural tube defect, varying degrees of spinal cord/meninges exposure.
- Cerebral Palsy: brain damage affecting movement/posture.
- Autism Spectrum Disorders: abnormal social interaction/communication, repetitive behaviors, limited interest.
Autonomic Nervous System
- Sympathetic Nervous System (SNS): active during stress/exercise; "fight-or-flight" response; short preganglionic fibers, long postganglionic fibers; uses acetylcholine (pre) and norepinephrine/epinephrine (post).
- Parasympathetic Nervous System (PNS): active during rest; "rest-and-digest" response; long preganglionic fibers, short postganglionic fibers; uses acetylcholine (pre and post).
Pain
- Nociceptors signal injury.
- Spinothalamic tract mediates pain.
- Referred pain: perceived from a different location of origin when nociceptive afferents converge on same second-order neuron.
Neuroplasticity
- Brain's ability to change function, chemical profiles, or structure.
- Recovery vs compensation.
- Experience-dependent plasticity: cellular changes due to experience.
- Experience-expectant plasticity: changes occurring during development.
- Cellular recovery after injury
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Description
Test your knowledge on the anatomy and functions of the Central Nervous System. This quiz covers major regions such as the brain, spinal cord, and important blood supply details including the Circle of Willis. Additionally, delve into the specific functions of the brain lobes and the role of the brainstem.