10 Questions
- What is the name of the enzyme that oxidizes isocitrate to generate alpha-ketoglutarate?
Isocitrate dehydrogenase
- What molecule is formed when alpha-ketoglutarate is decarboxylated and oxidized by alpha-ketoglutarate dehydrogenase?
Succinyl-CoA
- Which enzyme is responsible for the conversion of succinyl-CoA to succinate, releasing coenzyme A?
Succinyl-CoA synthetase
- What is the name of the enzyme that oxidizes succinate to fumarate, and where is it located?
Succinate dehydrogenase; inner mitochondrial membrane
- Which enzyme oxidizes malate to re-form oxaloacetate, and what molecule is reduced in the process?
Malate dehydrogenase; NAD+
Explain the role of acetyl-CoA in linking glycolysis and the citric acid cycle.
Acetyl-CoA is the key metabolic intermediate that links glycolysis and the citric acid cycle by carrying the two-carbon molecule acetate from glycolysis into the mitochondrial matrix, where it is further oxidized to form acetyl-CoA by the enzyme pyruvate dehydrogenase.
What is the function of citrate synthase in the citric acid cycle?
In the first step of the citric acid cycle, citrate synthase combines the two-carbon acetyl group from acetyl-CoA with the four-carbon molecule oxaloacetate to generate the six-carbon molecule citrate.
How is citrate converted to isocitrate in the citric acid cycle?
In the second step of the citric acid cycle, citrate is isomerized into isocitrate by the enzyme aconitase.
What are the products of the conversion of pyruvate to acetyl-CoA?
The conversion of pyruvate to acetyl-CoA results in the generation of a molecule of carbon dioxide and the reduction of a molecule of NAD+ to NADH.
How many NADH molecules are produced in the citric acid cycle?
The citric acid cycle produces a total of three NADH molecules.
Test your knowledge of cellular respiration by taking this quiz on the metabolic intermediate that links glycolysis and the citric acid cycle. This quiz covers the conversion of pyruvate to acetyl-CoA and its role in energy production within the cell.
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