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Questions and Answers
Where do normoblasts tend to develop within the hematopoietic cords?
Where do normoblasts tend to develop within the hematopoietic cords?
- Within the adipocytes
- Adjacent to the outer surfaces of the vascular sinuses (correct)
- In the center of the cords
- Close to the inactive marrow
What is the predominant type of marrow during infancy and childhood?
What is the predominant type of marrow during infancy and childhood?
- Inactive marrow
- Yellow marrow
- Extravascular cords
- Red marrow (correct)
In which trimester does the liver play a significant role in hematopoiesis?
In which trimester does the liver play a significant role in hematopoiesis?
- 3rd trimester
- No significant role in hematopoiesis
- 2nd trimester (correct)
- 1st trimester
What is the process of replacing red marrow by yellow marrow called?
What is the process of replacing red marrow by yellow marrow called?
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What is the function of the spleen in relation to platelets?
What is the function of the spleen in relation to platelets?
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Study Notes
Cell Death
- Necrosis: caused by direct external injury to cells
- Apoptosis: self-inflicted cell death
Hematopoiesis
- Definition: continuous, regulated process of blood cell production
- Types:
- Primitive Hematopoiesis: occurs during gestation
- Definitive Hematopoiesis: occurs in adults, defined process
Site of Hematopoiesis
- Ribs
- Sternum
- Scapula
- Skull
- Vertebrae
- Pelvic bones
- Proximal ends of the long bones
Extramedullary Hematopoiesis (EMH)
- Definition: production of blood cells outside of the bone marrow
- Occurs when there is inadequate production of blood cells
- Sites: Spleen and Liver
- Compensatory mechanism
Hemoglobin Types
- Gower 1: 2 zeta, 2 epsilon
- Gower 2: 2 alpha, 2 epsilon
- PL: 2 zeta, 2 gamma
- HbF: 2 alpha, 2 gamma
- HbA1: 2 alpha, 2 beta
- HbA2: 2 alpha, 2 delta
Primitive Erythroblasts
- Definition: erythrocytes, progenitor cells/ immature cells
- Post-Natal Hematopoiesis: After the first 3 weeks post-partum, the BM becomes the only normal site for blood cell production and remains throughout life
Adult Hematopoietic Tissue
- Bone Marrow
- Two types: Red Marrow and Yellow Marrow
- Active marrow: responsible for RBC production
- Chord blood: fetal blood
- Infancy, childhood development
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