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Questions and Answers
What is the primary function of TP53 in the context of cancer?
What is the primary function of TP53 in the context of cancer?
- Regulating cell cycle progression, DNA repair, and apoptosis (correct)
- Enhancing WNT signaling
- Inducing DNA damage
- Promoting cell proliferation
What is the effect of Li-Fraumeni syndrome on the development of cancers?
What is the effect of Li-Fraumeni syndrome on the development of cancers?
- A 5-fold decrease in the risk of developing cancers
- No significant effect on the risk of developing cancers
- Complete immunity to cancer development
- A 25-fold increase in the risk of developing cancers (correct)
How do MDM2 proteins regulate TP53?
How do MDM2 proteins regulate TP53?
- By degrading and downregulating TP53 (correct)
- By inhibiting WNT signaling
- By phosphorylating and activating TP53
- By enhancing DNA repair
What is the consequence of loss of p53 function in a cell?
What is the consequence of loss of p53 function in a cell?
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What is the effect of irradiating a tumor with wild-type TP53 compared to a tumor with mutated TP53?
What is the effect of irradiating a tumor with wild-type TP53 compared to a tumor with mutated TP53?
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Can TP53 mutations lead to a mutator phenotype?
Can TP53 mutations lead to a mutator phenotype?
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What is the function of APC in the context of cancer?
What is the function of APC in the context of cancer?
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How do patients with APC mutations typically present?
How do patients with APC mutations typically present?
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What is the role of E-cadherin in the regulation of cell proliferation?
What is the role of E-cadherin in the regulation of cell proliferation?
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What is the effect of loss of contact or mutation of E-cadherin on β-catenin?
What is the effect of loss of contact or mutation of E-cadherin on β-catenin?
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