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Cellular Metabolism and Apoptosis

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Questions and Answers

What is the primary function of TP53 in the context of cancer?

Regulating cell cycle progression, DNA repair, and apoptosis (correct)

Enhancing WNT signaling

Inducing DNA damage

Promoting cell proliferation

What is the effect of Li-Fraumeni syndrome on the development of cancers?

A 5-fold decrease in the risk of developing cancers

No significant effect on the risk of developing cancers

Complete immunity to cancer development

A 25-fold increase in the risk of developing cancers (correct)

How do MDM2 proteins regulate TP53?

By degrading and downregulating TP53 (correct)

By inhibiting WNT signaling

By phosphorylating and activating TP53

By enhancing DNA repair

What is the consequence of loss of p53 function in a cell?

DNA damage goes unrepaired, leading to accumulation of mutations Signup and view all the answers

What is the effect of irradiating a tumor with wild-type TP53 compared to a tumor with mutated TP53?

The tumor with wild-type TP53 undergoes apoptosis, while the tumor with mutated TP53 continues to proliferate Signup and view all the answers

Can TP53 mutations lead to a mutator phenotype?

Yes, TP53 mutations can lead to a mutator phenotype Signup and view all the answers

What is the function of APC in the context of cancer?

Downregulating WNT signaling Signup and view all the answers

How do patients with APC mutations typically present?

With multiple polyposis Signup and view all the answers

What is the role of E-cadherin in the regulation of cell proliferation?

Inhibiting cell proliferation Signup and view all the answers

What is the effect of loss of contact or mutation of E-cadherin on β-catenin?

β-catenin is released and can activate transcription Signup and view all the answers